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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-1881538-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=1881538&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 1881538,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001242932.2",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "NM_002339.3",
"protein_id": "NP_002330.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 339,
"cds_start": 298,
"cds_end": null,
"cds_length": 1020,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000311604.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002339.3"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000311604.8",
"protein_id": "ENSP00000308383.4",
"transcript_support_level": 1,
"aa_start": 100,
"aa_end": null,
"aa_length": 339,
"cds_start": 298,
"cds_end": null,
"cds_length": 1020,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002339.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000311604.8"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Ala228Pro",
"transcript": "NM_001242932.2",
"protein_id": "NP_001229861.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 467,
"cds_start": 682,
"cds_end": null,
"cds_length": 1404,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001242932.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Ala228Pro",
"transcript": "ENST00000381775.5",
"protein_id": "ENSP00000371194.1",
"transcript_support_level": 2,
"aa_start": 228,
"aa_end": null,
"aa_length": 467,
"cds_start": 682,
"cds_end": null,
"cds_length": 1404,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381775.5"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000962912.1",
"protein_id": "ENSP00000632971.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 348,
"cds_start": 298,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962912.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000861224.1",
"protein_id": "ENSP00000531283.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 339,
"cds_start": 298,
"cds_end": null,
"cds_length": 1020,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861224.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000861231.1",
"protein_id": "ENSP00000531290.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 339,
"cds_start": 298,
"cds_end": null,
"cds_length": 1020,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861231.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000861232.1",
"protein_id": "ENSP00000531291.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 339,
"cds_start": 298,
"cds_end": null,
"cds_length": 1020,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861232.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000861227.1",
"protein_id": "ENSP00000531286.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 337,
"cds_start": 298,
"cds_end": null,
"cds_length": 1014,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861227.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000861228.1",
"protein_id": "ENSP00000531287.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 337,
"cds_start": 298,
"cds_end": null,
"cds_length": 1014,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861228.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.298G>C",
"hgvs_p": "p.Ala100Pro",
"transcript": "ENST00000861230.1",
"protein_id": "ENSP00000531289.1",
"transcript_support_level": null,
"aa_start": 100,
"aa_end": null,
"aa_length": 297,
"cds_start": 298,
"cds_end": null,
"cds_length": 894,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861230.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.160G>C",
"hgvs_p": "p.Ala54Pro",
"transcript": "ENST00000861229.1",
"protein_id": "ENSP00000531288.1",
"transcript_support_level": null,
"aa_start": 54,
"aa_end": null,
"aa_length": 293,
"cds_start": 160,
"cds_end": null,
"cds_length": 882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861229.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "NM_001013253.2",
"protein_id": "NP_001013271.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001013253.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "NM_001013254.1",
"protein_id": "NP_001013272.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001013254.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "NM_001013255.1",
"protein_id": "NP_001013273.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001013255.1"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "NM_001289005.2",
"protein_id": "NP_001275934.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001289005.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "ENST00000405957.6",
"protein_id": "ENSP00000383932.2",
"transcript_support_level": 5,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405957.6"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "ENST00000406638.6",
"protein_id": "ENSP00000384022.2",
"transcript_support_level": 2,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000406638.6"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "ENST00000612798.4",
"protein_id": "ENSP00000484140.1",
"transcript_support_level": 2,
"aa_start": 38,
"aa_end": null,
"aa_length": 277,
"cds_start": 112,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000612798.4"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.271G>C",
"hgvs_p": "p.Ala91Pro",
"transcript": "ENST00000457279.5",
"protein_id": "ENSP00000400346.1",
"transcript_support_level": 5,
"aa_start": 91,
"aa_end": null,
"aa_length": 274,
"cds_start": 271,
"cds_end": null,
"cds_length": 825,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000457279.5"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "ENST00000417766.5",
"protein_id": "ENSP00000416363.1",
"transcript_support_level": 5,
"aa_start": 38,
"aa_end": null,
"aa_length": 221,
"cds_start": 112,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000417766.5"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LSP1",
"gene_hgnc_id": 6707,
"hgvs_c": "c.112G>C",
"hgvs_p": "p.Ala38Pro",
"transcript": "ENST00000432093.1",
"protein_id": "ENSP00000412405.1",
"transcript_support_level": 5,
"aa_start": 38,
"aa_end": null,
"aa_length": 221,
"cds_start": 112,
"cds_end": null,
"cds_length": 666,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000432093.1"
},
{
"aa_ref": "A",
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}
],
"message": null
}