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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-19225279-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=19225279&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "E2F8",
          "hgnc_id": 24727,
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NM_024680.4",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "CSRP3-AS1",
          "hgnc_id": 54183,
          "hgvs_c": "n.208-26966G>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NR_183675.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_score": 0,
      "allele_count_reference_population": 1,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0735,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.35,
      "chr": "11",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.2374972701072693,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3706,
          "cdna_start": 2870,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_024680.4",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000250024.9",
          "protein_coding": true,
          "protein_id": "NP_078956.2",
          "strand": false,
          "transcript": "NM_024680.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3706,
          "cdna_start": 2870,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000250024.9",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_024680.4",
          "protein_coding": true,
          "protein_id": "ENSP00000250024.4",
          "strand": false,
          "transcript": "ENST00000250024.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 875,
          "aa_ref": "P",
          "aa_start": 796,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3499,
          "cdna_start": 2665,
          "cds_end": null,
          "cds_length": 2628,
          "cds_start": 2387,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000928104.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2387C>T",
          "hgvs_p": "p.Pro796Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000598163.1",
          "strand": false,
          "transcript": "ENST00000928104.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3522,
          "cdna_start": 2686,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_001256371.2",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001243300.1",
          "strand": false,
          "transcript": "NM_001256371.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3467,
          "cdna_start": 2631,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "NM_001256372.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001243301.1",
          "strand": false,
          "transcript": "NM_001256372.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3432,
          "cdna_start": 2596,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000527884.5",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000434199.1",
          "strand": false,
          "transcript": "ENST00000527884.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3519,
          "cdna_start": 2686,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000620009.4",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000481103.1",
          "strand": false,
          "transcript": "ENST00000620009.4",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 867,
          "aa_ref": "P",
          "aa_start": 788,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3376,
          "cdna_start": 2548,
          "cds_end": null,
          "cds_length": 2604,
          "cds_start": 2363,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000966242.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2363C>T",
          "hgvs_p": "p.Pro788Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000636301.1",
          "strand": false,
          "transcript": "ENST00000966242.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 842,
          "aa_ref": "P",
          "aa_start": 763,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3421,
          "cdna_start": 2585,
          "cds_end": null,
          "cds_length": 2529,
          "cds_start": 2288,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000898597.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2288C>T",
          "hgvs_p": "p.Pro763Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568656.1",
          "strand": false,
          "transcript": "ENST00000898597.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 799,
          "aa_ref": "P",
          "aa_start": 720,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3284,
          "cdna_start": 2452,
          "cds_end": null,
          "cds_length": 2400,
          "cds_start": 2159,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000928103.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2159C>T",
          "hgvs_p": "p.Pro720Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000598162.1",
          "strand": false,
          "transcript": "ENST00000928103.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 762,
          "aa_ref": "P",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3115,
          "cdna_start": 2281,
          "cds_end": null,
          "cds_length": 2289,
          "cds_start": 2048,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000898598.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2048C>T",
          "hgvs_p": "p.Pro683Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568657.1",
          "strand": false,
          "transcript": "ENST00000898598.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 762,
          "aa_ref": "P",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3389,
          "cdna_start": 2561,
          "cds_end": null,
          "cds_length": 2289,
          "cds_start": 2048,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000966243.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2048C>T",
          "hgvs_p": "p.Pro683Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000636302.1",
          "strand": false,
          "transcript": "ENST00000966243.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 708,
          "aa_ref": "P",
          "aa_start": 629,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2951,
          "cdna_start": 2119,
          "cds_end": null,
          "cds_length": 2127,
          "cds_start": 1886,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000898599.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.1886C>T",
          "hgvs_p": "p.Pro629Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000568658.1",
          "strand": false,
          "transcript": "ENST00000898599.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 662,
          "aa_ref": "P",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3108,
          "cdna_start": 2276,
          "cds_end": null,
          "cds_length": 1989,
          "cds_start": 1748,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000928105.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.1748C>T",
          "hgvs_p": "p.Pro583Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000598164.1",
          "strand": false,
          "transcript": "ENST00000928105.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 762,
          "aa_ref": "P",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3391,
          "cdna_start": 2555,
          "cds_end": null,
          "cds_length": 2289,
          "cds_start": 2048,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "XM_011520367.2",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2048C>T",
          "hgvs_p": "p.Pro683Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011518669.1",
          "strand": false,
          "transcript": "XM_011520367.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 762,
          "aa_ref": "P",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3152,
          "cdna_start": 2316,
          "cds_end": null,
          "cds_length": 2289,
          "cds_start": 2048,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "XM_047427596.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2048C>T",
          "hgvs_p": "p.Pro683Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047283552.1",
          "strand": false,
          "transcript": "XM_047427596.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 762,
          "aa_ref": "P",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3207,
          "cdna_start": 2371,
          "cds_end": null,
          "cds_length": 2289,
          "cds_start": 2048,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "XM_047427597.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.2048C>T",
          "hgvs_p": "p.Pro683Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047283553.1",
          "strand": false,
          "transcript": "XM_047427597.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 744,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2850,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 2235,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "XM_047427598.1",
          "gene_hgnc_id": 24727,
          "gene_symbol": "E2F8",
          "hgvs_c": "c.*57C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047283554.1",
          "strand": false,
          "transcript": "XM_047427598.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.