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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-208916-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=208916&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 6,
          "criteria": [
            "BP4_Moderate",
            "BS2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "RIC8A",
          "hgnc_id": 29550,
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": -6,
          "transcript": "NM_021932.6",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate,BS2",
      "acmg_score": -6,
      "allele_count_reference_population": 6,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1614,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.27,
      "chr": "11",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.16149422526359558,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 531,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3506,
          "cdna_start": 1209,
          "cds_end": null,
          "cds_length": 1596,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "NM_001286134.2",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000526104.6",
          "protein_coding": true,
          "protein_id": "NP_001273063.1",
          "strand": true,
          "transcript": "NM_001286134.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 531,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3506,
          "cdna_start": 1209,
          "cds_end": null,
          "cds_length": 1596,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000526104.6",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001286134.2",
          "protein_coding": true,
          "protein_id": "ENSP00000432008.1",
          "strand": true,
          "transcript": "ENST00000526104.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 537,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2702,
          "cdna_start": 387,
          "cds_end": null,
          "cds_length": 1614,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000325207.9",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000325941.5",
          "strand": true,
          "transcript": "ENST00000325207.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 550,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2466,
          "cdna_start": 112,
          "cds_end": null,
          "cds_length": 1653,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853239.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523298.1",
          "strand": true,
          "transcript": "ENST00000853239.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 537,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3524,
          "cdna_start": 1209,
          "cds_end": null,
          "cds_length": 1614,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "NM_021932.6",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_068751.4",
          "strand": true,
          "transcript": "NM_021932.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 535,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3518,
          "cdna_start": 1209,
          "cds_end": null,
          "cds_length": 1608,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "NM_001386941.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001373870.1",
          "strand": true,
          "transcript": "NM_001386941.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 530,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2413,
          "cdna_start": 124,
          "cds_end": null,
          "cds_length": 1593,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853238.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523297.1",
          "strand": true,
          "transcript": "ENST00000853238.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 529,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2367,
          "cdna_start": 81,
          "cds_end": null,
          "cds_length": 1590,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853241.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523300.1",
          "strand": true,
          "transcript": "ENST00000853241.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 528,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2414,
          "cdna_start": 131,
          "cds_end": null,
          "cds_length": 1587,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853237.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523296.1",
          "strand": true,
          "transcript": "ENST00000853237.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 528,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3348,
          "cdna_start": 1065,
          "cds_end": null,
          "cds_length": 1587,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000941738.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000611797.1",
          "strand": true,
          "transcript": "ENST00000941738.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3679,
          "cdna_start": 1418,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000941737.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000611796.1",
          "strand": true,
          "transcript": "ENST00000941737.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 515,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2378,
          "cdna_start": 136,
          "cds_end": null,
          "cds_length": 1548,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853236.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523295.1",
          "strand": true,
          "transcript": "ENST00000853236.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 511,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1820,
          "cdna_start": 112,
          "cds_end": null,
          "cds_length": 1536,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853242.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523301.1",
          "strand": true,
          "transcript": "ENST00000853242.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 499,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3536,
          "cdna_start": 1340,
          "cds_end": null,
          "cds_length": 1500,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853235.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523294.1",
          "strand": true,
          "transcript": "ENST00000853235.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2254,
          "cdna_start": 77,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000853240.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523299.1",
          "strand": true,
          "transcript": "ENST00000853240.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 182,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 563,
          "cdna_start": 76,
          "cds_end": null,
          "cds_length": 549,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000530889.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000433968.1",
          "strand": true,
          "transcript": "ENST00000530889.1",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 147,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 500,
          "cdna_start": 117,
          "cds_end": null,
          "cds_length": 445,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 3,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000528357.5",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000436610.1",
          "strand": true,
          "transcript": "ENST00000528357.5",
          "transcript_support_level": 4
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 52,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 159,
          "cdna_start": 62,
          "cds_end": null,
          "cds_length": 159,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 2,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000626818.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000487470.1",
          "strand": true,
          "transcript": "ENST00000626818.1",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "G",
          "aa_end": null,
          "aa_length": 541,
          "aa_ref": "A",
          "aa_start": 21,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3536,
          "cdna_start": 1209,
          "cds_end": null,
          "cds_length": 1626,
          "cds_start": 62,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "XM_047427393.1",
          "gene_hgnc_id": 29550,
          "gene_symbol": "RIC8A",
          "hgvs_c": "c.62C>G",
          "hgvs_p": "p.Ala21Gly",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.