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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-218907-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=218907&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 218907,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001370310.1",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1104C>T",
"hgvs_p": "p.His368His",
"transcript": "NM_012239.6",
"protein_id": "NP_036371.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 399,
"cds_start": 1104,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 1118,
"cdna_end": null,
"cdna_length": 2882,
"mane_select": "ENST00000382743.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012239.6"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1104C>T",
"hgvs_p": "p.His368His",
"transcript": "ENST00000382743.9",
"protein_id": "ENSP00000372191.4",
"transcript_support_level": 1,
"aa_start": 368,
"aa_end": null,
"aa_length": 399,
"cds_start": 1104,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 1118,
"cdna_end": null,
"cdna_length": 2882,
"mane_select": "NM_012239.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000382743.9"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1149C>T",
"hgvs_p": "p.His383His",
"transcript": "ENST00000941617.1",
"protein_id": "ENSP00000611676.1",
"transcript_support_level": null,
"aa_start": 383,
"aa_end": null,
"aa_length": 432,
"cds_start": 1149,
"cds_end": null,
"cds_length": 1299,
"cdna_start": 1152,
"cdna_end": null,
"cdna_length": 1861,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941617.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1104C>T",
"hgvs_p": "p.His368His",
"transcript": "NM_001370310.1",
"protein_id": "NP_001357239.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 417,
"cds_start": 1104,
"cds_end": null,
"cds_length": 1254,
"cdna_start": 1118,
"cdna_end": null,
"cdna_length": 2936,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370310.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1104C>T",
"hgvs_p": "p.His368His",
"transcript": "ENST00000852931.1",
"protein_id": "ENSP00000522990.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 417,
"cds_start": 1104,
"cds_end": null,
"cds_length": 1254,
"cdna_start": 1164,
"cdna_end": null,
"cdna_length": 2984,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852931.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1044C>T",
"hgvs_p": "p.His348His",
"transcript": "ENST00000852943.1",
"protein_id": "ENSP00000523002.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 379,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1140,
"cdna_start": 1058,
"cdna_end": null,
"cdna_length": 1708,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852943.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1038C>T",
"hgvs_p": "p.His346His",
"transcript": "ENST00000852939.1",
"protein_id": "ENSP00000522998.1",
"transcript_support_level": null,
"aa_start": 346,
"aa_end": null,
"aa_length": 377,
"cds_start": 1038,
"cds_end": null,
"cds_length": 1134,
"cdna_start": 1087,
"cdna_end": null,
"cdna_length": 1742,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852939.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.1014C>T",
"hgvs_p": "p.His338His",
"transcript": "ENST00000934324.1",
"protein_id": "ENSP00000604383.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 369,
"cds_start": 1014,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 1027,
"cdna_end": null,
"cdna_length": 1683,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934324.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.942C>T",
"hgvs_p": "p.His314His",
"transcript": "ENST00000934321.1",
"protein_id": "ENSP00000604380.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 363,
"cds_start": 942,
"cds_end": null,
"cds_length": 1092,
"cdna_start": 979,
"cdna_end": null,
"cdna_length": 2399,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934321.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.912C>T",
"hgvs_p": "p.His304His",
"transcript": "NM_001370312.1",
"protein_id": "NP_001357241.1",
"transcript_support_level": null,
"aa_start": 304,
"aa_end": null,
"aa_length": 353,
"cds_start": 912,
"cds_end": null,
"cds_length": 1062,
"cdna_start": 926,
"cdna_end": null,
"cdna_length": 2744,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370312.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.912C>T",
"hgvs_p": "p.His304His",
"transcript": "ENST00000524564.5",
"protein_id": "ENSP00000432937.1",
"transcript_support_level": 2,
"aa_start": 304,
"aa_end": null,
"aa_length": 353,
"cds_start": 912,
"cds_end": null,
"cds_length": 1062,
"cdna_start": 938,
"cdna_end": null,
"cdna_length": 1395,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000524564.5"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.942C>T",
"hgvs_p": "p.His314His",
"transcript": "NM_001370314.1",
"protein_id": "NP_001357243.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 345,
"cds_start": 942,
"cds_end": null,
"cds_length": 1038,
"cdna_start": 956,
"cdna_end": null,
"cdna_length": 2720,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370314.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.942C>T",
"hgvs_p": "p.His314His",
"transcript": "ENST00000532956.5",
"protein_id": "ENSP00000433077.1",
"transcript_support_level": 2,
"aa_start": 314,
"aa_end": null,
"aa_length": 345,
"cds_start": 942,
"cds_end": null,
"cds_length": 1038,
"cdna_start": 966,
"cdna_end": null,
"cdna_length": 1235,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000532956.5"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.861C>T",
"hgvs_p": "p.His287His",
"transcript": "ENST00000852933.1",
"protein_id": "ENSP00000522992.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 336,
"cds_start": 861,
"cds_end": null,
"cds_length": 1011,
"cdna_start": 887,
"cdna_end": null,
"cdna_length": 2704,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852933.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.912C>T",
"hgvs_p": "p.His304His",
"transcript": "ENST00000852932.1",
"protein_id": "ENSP00000522991.1",
"transcript_support_level": null,
"aa_start": 304,
"aa_end": null,
"aa_length": 335,
"cds_start": 912,
"cds_end": null,
"cds_length": 1008,
"cdna_start": 948,
"cdna_end": null,
"cdna_length": 2712,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852932.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.861C>T",
"hgvs_p": "p.His287His",
"transcript": "NM_001370315.1",
"protein_id": "NP_001357244.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 318,
"cds_start": 861,
"cds_end": null,
"cds_length": 957,
"cdna_start": 875,
"cdna_end": null,
"cdna_length": 2639,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370315.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.861C>T",
"hgvs_p": "p.His287His",
"transcript": "ENST00000525319.5",
"protein_id": "ENSP00000435464.1",
"transcript_support_level": 2,
"aa_start": 287,
"aa_end": null,
"aa_length": 318,
"cds_start": 861,
"cds_end": null,
"cds_length": 957,
"cdna_start": 887,
"cdna_end": null,
"cdna_length": 1475,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525319.5"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.777C>T",
"hgvs_p": "p.His259His",
"transcript": "ENST00000852942.1",
"protein_id": "ENSP00000523001.1",
"transcript_support_level": null,
"aa_start": 259,
"aa_end": null,
"aa_length": 308,
"cds_start": 777,
"cds_end": null,
"cds_length": 927,
"cdna_start": 802,
"cdna_end": null,
"cdna_length": 1505,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852942.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.678C>T",
"hgvs_p": "p.His226His",
"transcript": "NM_001370321.1",
"protein_id": "NP_001357250.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 275,
"cds_start": 678,
"cds_end": null,
"cds_length": 828,
"cdna_start": 1139,
"cdna_end": null,
"cdna_length": 2957,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370321.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.678C>T",
"hgvs_p": "p.His226His",
"transcript": "NM_001370322.1",
"protein_id": "NP_001357251.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 275,
"cds_start": 678,
"cds_end": null,
"cds_length": 828,
"cdna_start": 1042,
"cdna_end": null,
"cdna_length": 2860,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370322.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.678C>T",
"hgvs_p": "p.His226His",
"transcript": "NM_001370323.1",
"protein_id": "NP_001357252.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 275,
"cds_start": 678,
"cds_end": null,
"cds_length": 828,
"cdna_start": 972,
"cdna_end": null,
"cdna_length": 2790,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370323.1"
},
{
"aa_ref": "H",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SIRT3",
"gene_hgnc_id": 14931,
"hgvs_c": "c.678C>T",
"hgvs_p": "p.His226His",
"transcript": "NM_001017524.3",
"protein_id": "NP_001017524.1",
"transcript_support_level": null,
"aa_start": 226,
"aa_end": null,
"aa_length": 257,
"cds_start": 678,
"cds_end": null,
"cds_length": 774,
"cdna_start": 972,
"cdna_end": null,
"cdna_length": 2736,
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}
],
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}