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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-2988691-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=2988691&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 2988691,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000380542.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3563T>C",
"hgvs_p": null,
"transcript": "NM_005969.4",
"protein_id": "NP_005960.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 375,
"cds_start": -4,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2463,
"mane_select": "ENST00000380542.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3563T>C",
"hgvs_p": null,
"transcript": "ENST00000380542.9",
"protein_id": "ENSP00000369915.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 375,
"cds_start": -4,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2463,
"mane_select": "NM_005969.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3563T>C",
"hgvs_p": null,
"transcript": "ENST00000448187.6",
"protein_id": "ENSP00000387783.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 398,
"cds_start": -4,
"cds_end": null,
"cds_length": 1197,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3563T>C",
"hgvs_p": null,
"transcript": "ENST00000703798.1",
"protein_id": "ENSP00000515483.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 387,
"cds_start": -4,
"cds_end": null,
"cds_length": 1164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3563T>C",
"hgvs_p": null,
"transcript": "NM_001369380.1",
"protein_id": "NP_001356309.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
"hgvs_p": null,
"transcript": "NM_001369381.1",
"protein_id": "NP_001356310.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2568,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
"hgvs_p": null,
"transcript": "NM_001369382.1",
"protein_id": "NP_001356311.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2494,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
"hgvs_p": null,
"transcript": "NM_001369383.1",
"protein_id": "NP_001356312.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2593,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3103T>C",
"hgvs_p": null,
"transcript": "NM_001369384.1",
"protein_id": "NP_001356313.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
"hgvs_p": null,
"transcript": "NM_001369385.1",
"protein_id": "NP_001356314.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 386,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": 2772,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-68+438T>C",
"hgvs_p": null,
"transcript": "NM_001369386.1",
"protein_id": "NP_001356315.1",
"transcript_support_level": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 2,
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"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
"hgvs_p": null,
"transcript": "NM_001369388.1",
"protein_id": "NP_001356317.1",
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
"hgvs_p": null,
"transcript": "ENST00000526115.5",
"protein_id": "ENSP00000436397.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "NAP1L4",
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"hgvs_c": "c.-18+3563T>C",
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"transcript": "ENST00000620138.4",
"protein_id": "ENSP00000481412.1",
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},
{
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],
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"gene_symbol": "NAP1L4",
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"hgvs_c": "c.-68+438T>C",
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"protein_id": "NP_001356304.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+438T>C",
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"transcript": "NM_001369376.1",
"protein_id": "NP_001356305.1",
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},
{
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],
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"gene_symbol": "NAP1L4",
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"hgvs_c": "c.-68+438T>C",
"hgvs_p": null,
"transcript": "NM_001369377.1",
"protein_id": "NP_001356306.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3103T>C",
"hgvs_p": null,
"transcript": "NM_001369378.1",
"protein_id": "NP_001356307.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+2218T>C",
"hgvs_p": null,
"transcript": "NM_001369379.1",
"protein_id": "NP_001356308.1",
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},
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],
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"gene_symbol": "NAP1L4",
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"hgvs_c": "c.-18+3103T>C",
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"transcript": "ENST00000430811.5",
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},
{
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],
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"gene_symbol": "NAP1L4",
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"hgvs_c": "c.-18+3538T>C",
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"transcript": "ENST00000529361.5",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-80+3563T>C",
"hgvs_p": null,
"transcript": "ENST00000399614.6",
"protein_id": "ENSP00000382523.2",
"transcript_support_level": 4,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NAP1L4",
"gene_hgnc_id": 7640,
"hgvs_c": "c.-18+3563T>C",
"hgvs_p": null,
"transcript": "ENST00000532325.6",
"protein_id": "ENSP00000436488.2",
"transcript_support_level": 5,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
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}
],
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}