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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-34641414-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=34641414&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 34641414,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000257831.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "NM_012153.6",
"protein_id": "NP_036285.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 300,
"cds_start": -4,
"cds_end": null,
"cds_length": 903,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5399,
"mane_select": "ENST00000257831.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "ENST00000257831.8",
"protein_id": "ENSP00000257831.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 300,
"cds_start": -4,
"cds_end": null,
"cds_length": 903,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5399,
"mane_select": "NM_012153.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.64-1214A>C",
"hgvs_p": null,
"transcript": "ENST00000531794.5",
"protein_id": "ENSP00000435835.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 322,
"cds_start": -4,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1481,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "ENST00000530286.5",
"protein_id": "ENSP00000433508.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 300,
"cds_start": -4,
"cds_end": null,
"cds_length": 903,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1280,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "ENST00000533754.5",
"protein_id": "ENSP00000435837.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 300,
"cds_start": -4,
"cds_end": null,
"cds_length": 903,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1501,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "ENST00000450654.6",
"protein_id": "ENSP00000399733.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 277,
"cds_start": -4,
"cds_end": null,
"cds_length": 834,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2519,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.64-1214A>C",
"hgvs_p": null,
"transcript": "NM_001206616.2",
"protein_id": "NP_001193545.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 322,
"cds_start": -4,
"cds_end": null,
"cds_length": 969,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5350,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.64-1214A>C",
"hgvs_p": null,
"transcript": "NM_001378052.1",
"protein_id": "NP_001364981.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 321,
"cds_start": -4,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5347,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.7-1214A>C",
"hgvs_p": null,
"transcript": "NM_001378053.1",
"protein_id": "NP_001364982.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 303,
"cds_start": -4,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5587,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "NM_001378041.1",
"protein_id": "NP_001364970.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 300,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-3-1214A>C",
"hgvs_p": null,
"transcript": "NM_001378042.1",
"protein_id": "NP_001364971.1",
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},
{
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"protein_coding": true,
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],
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"exon_count": 10,
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"gene_symbol": "EHF",
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"hgvs_c": "c.-161-594A>C",
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"transcript": "NM_001378043.1",
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"feature": null
},
{
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"strand": true,
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],
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"gene_symbol": "EHF",
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"hgvs_c": "c.-3-1214A>C",
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"transcript": "NM_001378044.1",
"protein_id": "NP_001364973.1",
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},
{
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"strand": true,
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],
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"gene_symbol": "EHF",
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"hgvs_c": "c.-3-1214A>C",
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"transcript": "NM_001378045.1",
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},
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],
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"transcript": "NM_001378047.1",
"protein_id": "NP_001364976.1",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "EHF",
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"hgvs_c": "c.-3-1214A>C",
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},
{
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"transcript": "NM_001378050.1",
"protein_id": "NP_001364979.1",
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},
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],
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"hgvs_c": "c.-161-594A>C",
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"transcript": "NM_001378051.1",
"protein_id": "NP_001364980.1",
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},
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "EHF",
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"hgvs_c": "c.7-1214A>C",
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],
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},
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"strand": true,
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],
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"intron_rank": 1,
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"gene_symbol": "EHF",
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"hgvs_c": "c.-3-1214A>C",
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"transcript": "NM_001378054.1",
"protein_id": "NP_001364983.1",
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"mane_select": null,
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"feature": null
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
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"gene_symbol": "EHF",
"gene_hgnc_id": 3246,
"hgvs_c": "c.-164-5025A>C",
"hgvs_p": null,
"transcript": "NM_001378056.1",
"protein_id": "NP_001364985.1",
"transcript_support_level": null,
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},
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