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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-35208126-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=35208126&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 35208126,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000428726.8",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1436T>A",
"hgvs_p": "p.Ile479Lys",
"transcript": "NM_000610.4",
"protein_id": "NP_000601.3",
"transcript_support_level": null,
"aa_start": 479,
"aa_end": null,
"aa_length": 742,
"cds_start": 1436,
"cds_end": null,
"cds_length": 2229,
"cdna_start": 1569,
"cdna_end": null,
"cdna_length": 5431,
"mane_select": "ENST00000428726.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1436T>A",
"hgvs_p": "p.Ile479Lys",
"transcript": "ENST00000428726.8",
"protein_id": "ENSP00000398632.2",
"transcript_support_level": 1,
"aa_start": 479,
"aa_end": null,
"aa_length": 742,
"cds_start": 1436,
"cds_end": null,
"cds_length": 2229,
"cdna_start": 1569,
"cdna_end": null,
"cdna_length": 5431,
"mane_select": "NM_000610.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1307T>A",
"hgvs_p": "p.Ile436Lys",
"transcript": "ENST00000415148.6",
"protein_id": "ENSP00000389830.2",
"transcript_support_level": 1,
"aa_start": 436,
"aa_end": null,
"aa_length": 699,
"cds_start": 1307,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1441,
"cdna_end": null,
"cdna_length": 2369,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.689T>A",
"hgvs_p": "p.Ile230Lys",
"transcript": "ENST00000433892.6",
"protein_id": "ENSP00000392331.2",
"transcript_support_level": 1,
"aa_start": 230,
"aa_end": null,
"aa_length": 493,
"cds_start": 689,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 805,
"cdna_end": null,
"cdna_length": 2292,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.668-3120T>A",
"hgvs_p": null,
"transcript": "ENST00000434472.6",
"protein_id": "ENSP00000404447.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 429,
"cds_start": -4,
"cds_end": null,
"cds_length": 1290,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1634,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.668-6726T>A",
"hgvs_p": null,
"transcript": "ENST00000263398.11",
"protein_id": "ENSP00000263398.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 361,
"cds_start": -4,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4288,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.668-11190T>A",
"hgvs_p": null,
"transcript": "ENST00000352818.8",
"protein_id": "ENSP00000309732.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 340,
"cds_start": -4,
"cds_end": null,
"cds_length": 1023,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1023,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.665-6726T>A",
"hgvs_p": null,
"transcript": "ENST00000442151.6",
"protein_id": "ENSP00000398099.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 293,
"cds_start": -4,
"cds_end": null,
"cds_length": 882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1825,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.234-13579T>A",
"hgvs_p": null,
"transcript": "ENST00000278386.10",
"protein_id": "ENSP00000278386.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 139,
"cds_start": -4,
"cds_end": null,
"cds_length": 420,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 484,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "n.*291-6726T>A",
"hgvs_p": null,
"transcript": "ENST00000425428.6",
"protein_id": "ENSP00000395953.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1768,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1439T>A",
"hgvs_p": "p.Ile480Lys",
"transcript": "NM_001440324.1",
"protein_id": "NP_001427253.1",
"transcript_support_level": null,
"aa_start": 480,
"aa_end": null,
"aa_length": 743,
"cds_start": 1439,
"cds_end": null,
"cds_length": 2232,
"cdna_start": 1572,
"cdna_end": null,
"cdna_length": 5434,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1433T>A",
"hgvs_p": "p.Ile478Lys",
"transcript": "NM_001440325.1",
"protein_id": "NP_001427254.1",
"transcript_support_level": null,
"aa_start": 478,
"aa_end": null,
"aa_length": 741,
"cds_start": 1433,
"cds_end": null,
"cds_length": 2226,
"cdna_start": 1566,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1346T>A",
"hgvs_p": "p.Ile449Lys",
"transcript": "NM_001440326.1",
"protein_id": "NP_001427255.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 712,
"cds_start": 1346,
"cds_end": null,
"cds_length": 2139,
"cdna_start": 1479,
"cdna_end": null,
"cdna_length": 5341,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1310T>A",
"hgvs_p": "p.Ile437Lys",
"transcript": "NM_001440327.1",
"protein_id": "NP_001427256.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 700,
"cds_start": 1310,
"cds_end": null,
"cds_length": 2103,
"cdna_start": 1443,
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"cdna_length": 5305,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1307T>A",
"hgvs_p": "p.Ile436Lys",
"transcript": "NM_001001389.2",
"protein_id": "NP_001001389.1",
"transcript_support_level": null,
"aa_start": 436,
"aa_end": null,
"aa_length": 699,
"cds_start": 1307,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1440,
"cdna_end": null,
"cdna_length": 5302,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1307T>A",
"hgvs_p": "p.Ile436Lys",
"transcript": "NM_001440328.1",
"protein_id": "NP_001427257.1",
"transcript_support_level": null,
"aa_start": 436,
"aa_end": null,
"aa_length": 699,
"cds_start": 1307,
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"cdna_start": 1440,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1298T>A",
"hgvs_p": "p.Ile433Lys",
"transcript": "NM_001440329.1",
"protein_id": "NP_001427258.1",
"transcript_support_level": null,
"aa_start": 433,
"aa_end": null,
"aa_length": 696,
"cds_start": 1298,
"cds_end": null,
"cds_length": 2091,
"cdna_start": 1431,
"cdna_end": null,
"cdna_length": 5293,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1283T>A",
"hgvs_p": "p.Ile428Lys",
"transcript": "NM_001440330.1",
"protein_id": "NP_001427259.1",
"transcript_support_level": null,
"aa_start": 428,
"aa_end": null,
"aa_length": 691,
"cds_start": 1283,
"cds_end": null,
"cds_length": 2076,
"cdna_start": 1416,
"cdna_end": null,
"cdna_length": 5278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1241T>A",
"hgvs_p": "p.Ile414Lys",
"transcript": "NM_001440331.1",
"protein_id": "NP_001427260.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 677,
"cds_start": 1241,
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"cdna_start": 1374,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1217T>A",
"hgvs_p": "p.Ile406Lys",
"transcript": "NM_001440332.1",
"protein_id": "NP_001427261.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 669,
"cds_start": 1217,
"cds_end": null,
"cds_length": 2010,
"cdna_start": 1350,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1307T>A",
"hgvs_p": "p.Ile436Lys",
"transcript": "NM_001440333.1",
"protein_id": "NP_001427262.1",
"transcript_support_level": null,
"aa_start": 436,
"aa_end": null,
"aa_length": 669,
"cds_start": 1307,
"cds_end": null,
"cds_length": 2010,
"cdna_start": 1440,
"cdna_end": null,
"cdna_length": 5212,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1193T>A",
"hgvs_p": "p.Ile398Lys",
"transcript": "NM_001440334.1",
"protein_id": "NP_001427263.1",
"transcript_support_level": null,
"aa_start": 398,
"aa_end": null,
"aa_length": 661,
"cds_start": 1193,
"cds_end": null,
"cds_length": 1986,
"cdna_start": 1326,
"cdna_end": null,
"cdna_length": 5188,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD44",
"gene_hgnc_id": 1681,
"hgvs_c": "c.1184T>A",
"hgvs_p": "p.Ile395Lys",
"transcript": "NM_001440335.1",
"protein_id": "NP_001427264.1",
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}