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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-35256786-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=35256786&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 35256786,
"ref": "T",
"alt": "A",
"effect": "3_prime_UTR_variant",
"transcript": "ENST00000278379.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "NM_004171.4",
"protein_id": "NP_004162.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 574,
"cds_start": -4,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12006,
"mane_select": "ENST00000278379.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "ENST00000278379.9",
"protein_id": "ENSP00000278379.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 574,
"cds_start": -4,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12006,
"mane_select": "NM_004171.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "NM_001439342.1",
"protein_id": "NP_001426271.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 570,
"cds_start": -4,
"cds_end": null,
"cds_length": 1713,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11520,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "NM_001195728.3",
"protein_id": "NP_001182657.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 565,
"cds_start": -4,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11639,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "NM_001252652.2",
"protein_id": "NP_001239581.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 565,
"cds_start": -4,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11704,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "NM_001439341.1",
"protein_id": "NP_001426270.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 565,
"cds_start": -4,
"cds_end": null,
"cds_length": 1698,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11548,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "NM_001439343.1",
"protein_id": "NP_001426272.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 496,
"cds_start": -4,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11772,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "XM_047427436.1",
"protein_id": "XP_047283392.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 602,
"cds_start": -4,
"cds_end": null,
"cds_length": 1809,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12128,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "XM_017018136.1",
"protein_id": "XP_016873625.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 579,
"cds_start": -4,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12303,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "XM_047427437.1",
"protein_id": "XP_047283393.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 572,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 11417,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "XM_017018138.2",
"protein_id": "XP_016873627.1",
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
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"exon_count": 11,
"intron_rank": null,
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"gene_symbol": "SLC1A2",
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"hgvs_c": "c.*4108A>T",
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"transcript": "XM_047427438.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
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"exon_count": 11,
"intron_rank": null,
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"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
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"transcript": "XM_047427440.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 11,
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"exon_count": 11,
"intron_rank": null,
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"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
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"transcript": "XM_047427442.1",
"protein_id": "XP_047283398.1",
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},
{
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"3_prime_UTR_variant"
],
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"intron_rank": null,
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"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
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"transcript": "XM_047427443.1",
"protein_id": "XP_047283399.1",
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 10,
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"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "SLC1A2",
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"hgvs_c": "c.*4108A>T",
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"transcript": "XM_047427441.1",
"protein_id": "XP_047283397.1",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 6,
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"gene_symbol": "SLC1A2",
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"hgvs_c": "c.*51-1978A>T",
"hgvs_p": null,
"transcript": "ENST00000642769.1",
"protein_id": "ENSP00000493843.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*51-1978A>T",
"hgvs_p": null,
"transcript": "ENST00000647076.1",
"protein_id": "ENSP00000496759.1",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 2,
"intron_rank": 1,
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"gene_symbol": "SLC1A2",
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"hgvs_c": "c.220-1978A>T",
"hgvs_p": null,
"transcript": "ENST00000464522.2",
"protein_id": "ENSP00000435406.1",
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},
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"intron_variant"
],
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"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SLC1A2-AS1",
"gene_hgnc_id": 40534,
"hgvs_c": "n.426+18392T>A",
"hgvs_p": null,
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},
{
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "SLC1A2-AS1",
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "SLC1A2-AS1",
"gene_hgnc_id": 40534,
"hgvs_c": "n.426-4128T>A",
"hgvs_p": null,
"transcript": "ENST00000844197.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"downstream_gene_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.*4108A>T",
"hgvs_p": null,
"transcript": "ENST00000395750.6",
"protein_id": "ENSP00000379099.2",
"transcript_support_level": 1,
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"cds_start": -4,
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{
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}
],
"message": null
}