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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-35306201-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=35306201&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 35306201,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000278379.9",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.603G>A",
"hgvs_p": "p.Pro201Pro",
"transcript": "NM_004171.4",
"protein_id": "NP_004162.2",
"transcript_support_level": null,
"aa_start": 201,
"aa_end": null,
"aa_length": 574,
"cds_start": 603,
"cds_end": null,
"cds_length": 1725,
"cdna_start": 1195,
"cdna_end": null,
"cdna_length": 12006,
"mane_select": "ENST00000278379.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.603G>A",
"hgvs_p": "p.Pro201Pro",
"transcript": "ENST00000278379.9",
"protein_id": "ENSP00000278379.3",
"transcript_support_level": 1,
"aa_start": 201,
"aa_end": null,
"aa_length": 574,
"cds_start": 603,
"cds_end": null,
"cds_length": 1725,
"cdna_start": 1195,
"cdna_end": null,
"cdna_length": 12006,
"mane_select": "NM_004171.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.591G>A",
"hgvs_p": "p.Pro197Pro",
"transcript": "ENST00000395750.6",
"protein_id": "ENSP00000379099.2",
"transcript_support_level": 1,
"aa_start": 197,
"aa_end": null,
"aa_length": 570,
"cds_start": 591,
"cds_end": null,
"cds_length": 1713,
"cdna_start": 709,
"cdna_end": null,
"cdna_length": 5773,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.714G>A",
"hgvs_p": "p.Pro238Pro",
"transcript": "ENST00000644779.1",
"protein_id": "ENSP00000494258.1",
"transcript_support_level": null,
"aa_start": 238,
"aa_end": null,
"aa_length": 611,
"cds_start": 714,
"cds_end": null,
"cds_length": 1836,
"cdna_start": 1541,
"cdna_end": null,
"cdna_length": 4482,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.603G>A",
"hgvs_p": "p.Pro201Pro",
"transcript": "ENST00000643134.1",
"protein_id": "ENSP00000495188.1",
"transcript_support_level": null,
"aa_start": 201,
"aa_end": null,
"aa_length": 582,
"cds_start": 603,
"cds_end": null,
"cds_length": 1749,
"cdna_start": 992,
"cdna_end": null,
"cdna_length": 2138,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.618G>A",
"hgvs_p": "p.Pro206Pro",
"transcript": "ENST00000645303.1",
"protein_id": "ENSP00000496667.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 579,
"cds_start": 618,
"cds_end": null,
"cds_length": 1740,
"cdna_start": 907,
"cdna_end": null,
"cdna_length": 3952,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.603G>A",
"hgvs_p": "p.Pro201Pro",
"transcript": "ENST00000531628.2",
"protein_id": "ENSP00000436029.2",
"transcript_support_level": 5,
"aa_start": 201,
"aa_end": null,
"aa_length": 573,
"cds_start": 603,
"cds_end": null,
"cds_length": 1724,
"cdna_start": 603,
"cdna_end": null,
"cdna_length": 1724,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.594G>A",
"hgvs_p": "p.Pro198Pro",
"transcript": "ENST00000646080.1",
"protein_id": "ENSP00000494113.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 571,
"cds_start": 594,
"cds_end": null,
"cds_length": 1716,
"cdna_start": 672,
"cdna_end": null,
"cdna_length": 2002,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.591G>A",
"hgvs_p": "p.Pro197Pro",
"transcript": "NM_001439342.1",
"protein_id": "NP_001426271.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 570,
"cds_start": 591,
"cds_end": null,
"cds_length": 1713,
"cdna_start": 709,
"cdna_end": null,
"cdna_length": 11520,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "NM_001195728.3",
"protein_id": "NP_001182657.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 828,
"cdna_end": null,
"cdna_length": 11639,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "NM_001252652.2",
"protein_id": "NP_001239581.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 893,
"cdna_end": null,
"cdna_length": 11704,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "NM_001439341.1",
"protein_id": "NP_001426270.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 737,
"cdna_end": null,
"cdna_length": 11548,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000395753.6",
"protein_id": "ENSP00000379102.1",
"transcript_support_level": 2,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 736,
"cdna_end": null,
"cdna_length": 5800,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000643000.1",
"protein_id": "ENSP00000495164.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 691,
"cdna_end": null,
"cdna_length": 3343,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000644050.1",
"protein_id": "ENSP00000496123.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 1042,
"cdna_end": null,
"cdna_length": 4086,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000644299.1",
"protein_id": "ENSP00000494669.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
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"cds_start": 576,
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"cdna_start": 748,
"cdna_end": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000645194.1",
"protein_id": "ENSP00000496093.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 647,
"cdna_end": null,
"cdna_length": 2826,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000645634.1",
"protein_id": "ENSP00000493945.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 898,
"cdna_end": null,
"cdna_length": 3564,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.576G>A",
"hgvs_p": "p.Pro192Pro",
"transcript": "ENST00000647104.1",
"protein_id": "ENSP00000494025.1",
"transcript_support_level": null,
"aa_start": 192,
"aa_end": null,
"aa_length": 565,
"cds_start": 576,
"cds_end": null,
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"cdna_start": 755,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.603G>A",
"hgvs_p": "p.Pro201Pro",
"transcript": "ENST00000643305.1",
"protein_id": "ENSP00000494828.1",
"transcript_support_level": null,
"aa_start": 201,
"aa_end": null,
"aa_length": 563,
"cds_start": 603,
"cds_end": null,
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"cdna_start": 1190,
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"cdna_length": 2798,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.603G>A",
"hgvs_p": "p.Pro201Pro",
"transcript": "ENST00000642171.1",
"protein_id": "ENSP00000495538.1",
"transcript_support_level": null,
"aa_start": 201,
"aa_end": null,
"aa_length": 562,
"cds_start": 603,
"cds_end": null,
"cds_length": 1689,
"cdna_start": 850,
"cdna_end": null,
"cdna_length": 5985,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.594G>A",
"hgvs_p": "p.Pro198Pro",
"transcript": "ENST00000643454.1",
"protein_id": "ENSP00000495126.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 560,
"cds_start": 594,
"cds_end": null,
"cds_length": 1683,
"cdna_start": 632,
"cdna_end": null,
"cdna_length": 2379,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC1A2",
"gene_hgnc_id": 10940,
"hgvs_c": "c.594G>A",
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"phylop100way_prediction": "Benign",
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{
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"BP7",
"BA1"
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"verdict": "Benign",
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"effects": [
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],
"clinvar_disease": " 41,Developmental and epileptic encephalopathy,not provided",
"clinvar_classification": "Benign",
"clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
"clinvar_submissions_summary": "B:3",
"phenotype_combined": "not provided|Developmental and epileptic encephalopathy, 41",
"pathogenicity_classification_combined": "Benign",
"custom_annotations": null
}
],
"message": null
}