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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-3683340-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=3683340&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 8,
          "criteria": [
            "BP4_Strong",
            "BS2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "NUP98",
          "hgnc_id": 8068,
          "hgvs_c": "c.4871G>A",
          "hgvs_p": "p.Arg1624His",
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": -8,
          "transcript": "NM_001365125.2",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BS2",
      "acmg_score": -8,
      "allele_count_reference_population": 69,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0679,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.37,
      "chr": "11",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.05567145347595215,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1800,
          "aa_ref": "R",
          "aa_start": 1593,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6726,
          "cdna_start": 4961,
          "cds_end": null,
          "cds_length": 5403,
          "cds_start": 4778,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "NM_016320.5",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4778G>A",
          "hgvs_p": "p.Arg1593His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000324932.12",
          "protein_coding": true,
          "protein_id": "NP_057404.2",
          "strand": false,
          "transcript": "NM_016320.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1800,
          "aa_ref": "R",
          "aa_start": 1593,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 6726,
          "cdna_start": 4961,
          "cds_end": null,
          "cds_length": 5403,
          "cds_start": 4778,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000324932.12",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4778G>A",
          "hgvs_p": "p.Arg1593His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_016320.5",
          "protein_coding": true,
          "protein_id": "ENSP00000316032.7",
          "strand": false,
          "transcript": "ENST00000324932.12",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 752,
          "aa_ref": "R",
          "aa_start": 545,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2541,
          "cdna_start": 1635,
          "cds_end": null,
          "cds_length": 2259,
          "cds_start": 1634,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000429801.5",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.1634G>A",
          "hgvs_p": "p.Arg545His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000413146.1",
          "strand": false,
          "transcript": "ENST00000429801.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1848,
          "aa_ref": "R",
          "aa_start": 1641,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6884,
          "cdna_start": 5105,
          "cds_end": null,
          "cds_length": 5547,
          "cds_start": 4922,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000915300.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4922G>A",
          "hgvs_p": "p.Arg1641His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585359.1",
          "strand": false,
          "transcript": "ENST00000915300.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1831,
          "aa_ref": "R",
          "aa_start": 1624,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6819,
          "cdna_start": 5054,
          "cds_end": null,
          "cds_length": 5496,
          "cds_start": 4871,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "NM_001365125.2",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4871G>A",
          "hgvs_p": "p.Arg1624His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001352054.1",
          "strand": false,
          "transcript": "NM_001365125.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1831,
          "aa_ref": "R",
          "aa_start": 1624,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6830,
          "cdna_start": 5056,
          "cds_end": null,
          "cds_length": 5496,
          "cds_start": 4871,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000915302.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4871G>A",
          "hgvs_p": "p.Arg1624His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585361.1",
          "strand": false,
          "transcript": "ENST00000915302.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1822,
          "aa_ref": "R",
          "aa_start": 1615,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6790,
          "cdna_start": 5025,
          "cds_end": null,
          "cds_length": 5469,
          "cds_start": 4844,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000915311.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4844G>A",
          "hgvs_p": "p.Arg1615His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585370.1",
          "strand": false,
          "transcript": "ENST00000915311.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1817,
          "aa_ref": "R",
          "aa_start": 1610,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6777,
          "cdna_start": 5012,
          "cds_end": null,
          "cds_length": 5454,
          "cds_start": 4829,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "NM_001365126.2",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4829G>A",
          "hgvs_p": "p.Arg1610His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001352055.1",
          "strand": false,
          "transcript": "NM_001365126.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1817,
          "aa_ref": "R",
          "aa_start": 1610,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7023,
          "cdna_start": 5250,
          "cds_end": null,
          "cds_length": 5454,
          "cds_start": 4829,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000359171.8",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4829G>A",
          "hgvs_p": "p.Arg1610His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000352091.5",
          "strand": false,
          "transcript": "ENST00000359171.8",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1817,
          "aa_ref": "R",
          "aa_start": 1610,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6893,
          "cdna_start": 5129,
          "cds_end": null,
          "cds_length": 5454,
          "cds_start": 4829,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000915310.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4829G>A",
          "hgvs_p": "p.Arg1610His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585369.1",
          "strand": false,
          "transcript": "ENST00000915310.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1815,
          "aa_ref": "R",
          "aa_start": 1608,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5909,
          "cdna_start": 5000,
          "cds_end": null,
          "cds_length": 5448,
          "cds_start": 4823,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000943238.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4823G>A",
          "hgvs_p": "p.Arg1608His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000613297.1",
          "strand": false,
          "transcript": "ENST00000943238.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1808,
          "aa_ref": "R",
          "aa_start": 1601,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6761,
          "cdna_start": 4987,
          "cds_end": null,
          "cds_length": 5427,
          "cds_start": 4802,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000915303.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4802G>A",
          "hgvs_p": "p.Arg1601His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585362.1",
          "strand": false,
          "transcript": "ENST00000915303.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1800,
          "aa_ref": "R",
          "aa_start": 1593,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5971,
          "cdna_start": 5064,
          "cds_end": null,
          "cds_length": 5403,
          "cds_start": 4778,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000851290.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4778G>A",
          "hgvs_p": "p.Arg1593His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000521349.1",
          "strand": false,
          "transcript": "ENST00000851290.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1800,
          "aa_ref": "R",
          "aa_start": 1593,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6838,
          "cdna_start": 5073,
          "cds_end": null,
          "cds_length": 5403,
          "cds_start": 4778,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000915312.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4778G>A",
          "hgvs_p": "p.Arg1593His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585371.1",
          "strand": false,
          "transcript": "ENST00000915312.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1800,
          "aa_ref": "R",
          "aa_start": 1593,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5978,
          "cdna_start": 5072,
          "cds_end": null,
          "cds_length": 5403,
          "cds_start": 4778,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 31,
          "exon_rank_end": null,
          "feature": "ENST00000915314.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4778G>A",
          "hgvs_p": "p.Arg1593His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585373.1",
          "strand": false,
          "transcript": "ENST00000915314.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1792,
          "aa_ref": "R",
          "aa_start": 1585,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6702,
          "cdna_start": 4937,
          "cds_end": null,
          "cds_length": 5379,
          "cds_start": 4754,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "NM_001365127.2",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4754G>A",
          "hgvs_p": "p.Arg1585His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001352056.1",
          "strand": false,
          "transcript": "NM_001365127.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1792,
          "aa_ref": "R",
          "aa_start": 1585,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6691,
          "cdna_start": 4937,
          "cds_end": null,
          "cds_length": 5379,
          "cds_start": 4754,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000527104.6",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4754G>A",
          "hgvs_p": "p.Arg1585His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000436226.2",
          "strand": false,
          "transcript": "ENST00000527104.6",
          "transcript_support_level": 3
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1791,
          "aa_ref": "R",
          "aa_start": 1584,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6641,
          "cdna_start": 4887,
          "cds_end": null,
          "cds_length": 5376,
          "cds_start": 4751,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000700597.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
          "hgvs_c": "c.4751G>A",
          "hgvs_p": "p.Arg1584His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000515087.1",
          "strand": false,
          "transcript": "ENST00000700597.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 1784,
          "aa_ref": "R",
          "aa_start": 1577,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6679,
          "cdna_start": 4916,
          "cds_end": null,
          "cds_length": 5355,
          "cds_start": 4730,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 33,
          "exon_rank": 30,
          "exon_rank_end": null,
          "feature": "ENST00000915306.1",
          "gene_hgnc_id": 8068,
          "gene_symbol": "NUP98",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.