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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-43451557-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=43451557&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 43451557,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001376525.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3030+292T>C",
"hgvs_p": null,
"transcript": "NM_018259.6",
"protein_id": "NP_060729.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1141,
"cds_start": null,
"cds_end": null,
"cds_length": 3426,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000039989.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018259.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3030+292T>C",
"hgvs_p": null,
"transcript": "ENST00000039989.9",
"protein_id": "ENSP00000039989.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1141,
"cds_start": null,
"cds_end": null,
"cds_length": 3426,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018259.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000039989.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3213+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867749.1",
"protein_id": "ENSP00000537808.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1202,
"cds_start": null,
"cds_end": null,
"cds_length": 3609,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867749.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3204+292T>C",
"hgvs_p": null,
"transcript": "ENST00000969881.1",
"protein_id": "ENSP00000639940.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1199,
"cds_start": null,
"cds_end": null,
"cds_length": 3600,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969881.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3201+292T>C",
"hgvs_p": null,
"transcript": "NM_001376525.1",
"protein_id": "NP_001363454.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1198,
"cds_start": null,
"cds_end": null,
"cds_length": 3597,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376525.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3201+292T>C",
"hgvs_p": null,
"transcript": "ENST00000703837.1",
"protein_id": "ENSP00000515494.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1198,
"cds_start": null,
"cds_end": null,
"cds_length": 3597,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000703837.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3153+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867746.1",
"protein_id": "ENSP00000537805.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1182,
"cds_start": null,
"cds_end": null,
"cds_length": 3549,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867746.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3150+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867744.1",
"protein_id": "ENSP00000537803.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1181,
"cds_start": null,
"cds_end": null,
"cds_length": 3546,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867744.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3150+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867747.1",
"protein_id": "ENSP00000537806.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1181,
"cds_start": null,
"cds_end": null,
"cds_length": 3546,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867747.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3123+292T>C",
"hgvs_p": null,
"transcript": "ENST00000969882.1",
"protein_id": "ENSP00000639941.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1172,
"cds_start": null,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969882.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3111+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867750.1",
"protein_id": "ENSP00000537809.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1168,
"cds_start": null,
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"cds_length": 3507,
"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000867750.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3102+292T>C",
"hgvs_p": null,
"transcript": "ENST00000969883.1",
"protein_id": "ENSP00000639942.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1165,
"cds_start": null,
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"cds_length": 3498,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969883.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.3072+292T>C",
"hgvs_p": null,
"transcript": "ENST00000969885.1",
"protein_id": "ENSP00000639944.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000969885.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.2979+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867745.1",
"protein_id": "ENSP00000537804.1",
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"biotype": "protein_coding",
"feature": "ENST00000867745.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.2940+292T>C",
"hgvs_p": null,
"transcript": "NM_001376526.1",
"protein_id": "NP_001363455.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1111,
"cds_start": null,
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"cds_length": 3336,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376526.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "TTC17",
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"hgvs_c": "c.2919+292T>C",
"hgvs_p": null,
"transcript": "ENST00000867748.1",
"protein_id": "ENSP00000537807.1",
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867748.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.2616+292T>C",
"hgvs_p": null,
"transcript": "NM_001376527.1",
"protein_id": "NP_001363456.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1003,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376527.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.2532+292T>C",
"hgvs_p": null,
"transcript": "NM_001376528.1",
"protein_id": "NP_001363457.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 975,
"cds_start": null,
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"biotype": "protein_coding",
"feature": "NM_001376528.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.2532+292T>C",
"hgvs_p": null,
"transcript": "ENST00000929847.1",
"protein_id": "ENSP00000599906.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.2118+292T>C",
"hgvs_p": null,
"transcript": "ENST00000969884.1",
"protein_id": "ENSP00000639943.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.664-38682T>C",
"hgvs_p": null,
"transcript": "ENST00000929846.1",
"protein_id": "ENSP00000599905.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 352,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929846.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TTC17",
"gene_hgnc_id": 25596,
"hgvs_c": "c.84+292T>C",
"hgvs_p": null,
"transcript": "ENST00000418561.2",
"protein_id": "ENSP00000407314.2",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 171,
"cds_start": null,
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"cds_length": 516,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000418561.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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}
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}