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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-44077347-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=44077347&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 44077347,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_032592.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "NM_032592.4",
"protein_id": "NP_115981.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 501,
"cds_start": 625,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000263776.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032592.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "ENST00000263776.9",
"protein_id": "ENSP00000263776.8",
"transcript_support_level": 1,
"aa_start": 209,
"aa_end": null,
"aa_length": 501,
"cds_start": 625,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032592.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000263776.9"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Pro295Gln",
"transcript": "XM_017018421.2",
"protein_id": "XP_016873910.1",
"transcript_support_level": null,
"aa_start": 295,
"aa_end": null,
"aa_length": 303,
"cds_start": 884,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017018421.2"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Pro295Gln",
"transcript": "XM_047427719.1",
"protein_id": "XP_047283675.1",
"transcript_support_level": null,
"aa_start": 295,
"aa_end": null,
"aa_length": 303,
"cds_start": 884,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427719.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "NM_001127219.2",
"protein_id": "NP_001120691.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 501,
"cds_start": 625,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127219.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "ENST00000894384.1",
"protein_id": "ENSP00000564443.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 501,
"cds_start": 625,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894384.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "ENST00000964372.1",
"protein_id": "ENSP00000634431.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 501,
"cds_start": 625,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964372.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "ENST00000894383.1",
"protein_id": "ENSP00000564442.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 500,
"cds_start": 625,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894383.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.565C>A",
"hgvs_p": "p.Arg189Arg",
"transcript": "ENST00000894381.1",
"protein_id": "ENSP00000564440.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 481,
"cds_start": 565,
"cds_end": null,
"cds_length": 1446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894381.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "ENST00000964373.1",
"protein_id": "ENSP00000634432.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 475,
"cds_start": 625,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964373.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.484C>A",
"hgvs_p": "p.Arg162Arg",
"transcript": "ENST00000894382.1",
"protein_id": "ENSP00000564441.1",
"transcript_support_level": null,
"aa_start": 162,
"aa_end": null,
"aa_length": 454,
"cds_start": 484,
"cds_end": null,
"cds_length": 1365,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894382.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.928C>A",
"hgvs_p": "p.Arg310Arg",
"transcript": "XM_005253170.4",
"protein_id": "XP_005253227.2",
"transcript_support_level": null,
"aa_start": 310,
"aa_end": null,
"aa_length": 602,
"cds_start": 928,
"cds_end": null,
"cds_length": 1809,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005253170.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.928C>A",
"hgvs_p": "p.Arg310Arg",
"transcript": "XM_011520406.3",
"protein_id": "XP_011518708.1",
"transcript_support_level": null,
"aa_start": 310,
"aa_end": null,
"aa_length": 576,
"cds_start": 928,
"cds_end": null,
"cds_length": 1731,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520406.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "XM_024448718.2",
"protein_id": "XP_024304486.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 475,
"cds_start": 625,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448718.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.625C>A",
"hgvs_p": "p.Arg209Arg",
"transcript": "XM_024448719.2",
"protein_id": "XP_024304487.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 475,
"cds_start": 625,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024448719.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.262C>A",
"hgvs_p": "p.Arg88Arg",
"transcript": "XM_011520407.1",
"protein_id": "XP_011518709.1",
"transcript_support_level": null,
"aa_start": 88,
"aa_end": null,
"aa_length": 380,
"cds_start": 262,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520407.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.235C>A",
"hgvs_p": "p.Arg79Arg",
"transcript": "XM_005253172.2",
"protein_id": "XP_005253229.1",
"transcript_support_level": null,
"aa_start": 79,
"aa_end": null,
"aa_length": 371,
"cds_start": 235,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005253172.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.928C>A",
"hgvs_p": "p.Arg310Arg",
"transcript": "XM_047427717.1",
"protein_id": "XP_047283673.1",
"transcript_support_level": null,
"aa_start": 310,
"aa_end": null,
"aa_length": 326,
"cds_start": 928,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427717.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.79C>A",
"hgvs_p": "p.Arg27Arg",
"transcript": "XM_006718348.3",
"protein_id": "XP_006718411.1",
"transcript_support_level": null,
"aa_start": 27,
"aa_end": null,
"aa_length": 319,
"cds_start": 79,
"cds_end": null,
"cds_length": 960,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006718348.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "c.79C>A",
"hgvs_p": "p.Arg27Arg",
"transcript": "XM_047427718.1",
"protein_id": "XP_047283674.1",
"transcript_support_level": null,
"aa_start": 27,
"aa_end": null,
"aa_length": 319,
"cds_start": 79,
"cds_end": null,
"cds_length": 960,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427718.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "n.809C>A",
"hgvs_p": null,
"transcript": "ENST00000526577.5",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000526577.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACCS",
"gene_hgnc_id": 23989,
"hgvs_c": "n.87C>A",
"hgvs_p": null,
"transcript": "ENST00000527346.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000527346.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
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"splice_prediction_selected": "Benign",
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"bayesdelnoaf_prediction": "Benign",
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"phylop100way_prediction": "Benign",
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{
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"BP7"
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"verdict": "Likely_benign",
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"clinvar_review_status": "",
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}
],
"message": null
}