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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-46739326-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=46739326&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 46739326,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_000506.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1787G>T",
"hgvs_p": "p.Arg596Leu",
"transcript": "NM_000506.5",
"protein_id": "NP_000497.1",
"transcript_support_level": null,
"aa_start": 596,
"aa_end": null,
"aa_length": 622,
"cds_start": 1787,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000311907.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000506.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1787G>T",
"hgvs_p": "p.Arg596Leu",
"transcript": "ENST00000311907.10",
"protein_id": "ENSP00000308541.5",
"transcript_support_level": 1,
"aa_start": 596,
"aa_end": null,
"aa_length": 622,
"cds_start": 1787,
"cds_end": null,
"cds_length": 1869,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000506.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000311907.10"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1883G>T",
"hgvs_p": "p.Arg628Leu",
"transcript": "ENST00000862106.1",
"protein_id": "ENSP00000532165.1",
"transcript_support_level": null,
"aa_start": 628,
"aa_end": null,
"aa_length": 654,
"cds_start": 1883,
"cds_end": null,
"cds_length": 1965,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862106.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1835G>T",
"hgvs_p": "p.Arg612Leu",
"transcript": "ENST00000862118.1",
"protein_id": "ENSP00000532177.1",
"transcript_support_level": null,
"aa_start": 612,
"aa_end": null,
"aa_length": 638,
"cds_start": 1835,
"cds_end": null,
"cds_length": 1917,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862118.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1832G>T",
"hgvs_p": "p.Arg611Leu",
"transcript": "ENST00000862102.1",
"protein_id": "ENSP00000532161.1",
"transcript_support_level": null,
"aa_start": 611,
"aa_end": null,
"aa_length": 637,
"cds_start": 1832,
"cds_end": null,
"cds_length": 1914,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862102.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1826G>T",
"hgvs_p": "p.Arg609Leu",
"transcript": "ENST00000862104.1",
"protein_id": "ENSP00000532163.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 635,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1908,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862104.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1814G>T",
"hgvs_p": "p.Arg605Leu",
"transcript": "ENST00000862111.1",
"protein_id": "ENSP00000532170.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 631,
"cds_start": 1814,
"cds_end": null,
"cds_length": 1896,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862111.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1808G>T",
"hgvs_p": "p.Arg603Leu",
"transcript": "ENST00000862105.1",
"protein_id": "ENSP00000532164.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 629,
"cds_start": 1808,
"cds_end": null,
"cds_length": 1890,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862105.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1784G>T",
"hgvs_p": "p.Arg595Leu",
"transcript": "ENST00000862096.1",
"protein_id": "ENSP00000532155.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 621,
"cds_start": 1784,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862096.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1775G>T",
"hgvs_p": "p.Arg592Leu",
"transcript": "ENST00000862107.1",
"protein_id": "ENSP00000532166.1",
"transcript_support_level": null,
"aa_start": 592,
"aa_end": null,
"aa_length": 618,
"cds_start": 1775,
"cds_end": null,
"cds_length": 1857,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862107.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1769G>T",
"hgvs_p": "p.Arg590Leu",
"transcript": "ENST00000862112.1",
"protein_id": "ENSP00000532171.1",
"transcript_support_level": null,
"aa_start": 590,
"aa_end": null,
"aa_length": 616,
"cds_start": 1769,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862112.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1766G>T",
"hgvs_p": "p.Arg589Leu",
"transcript": "ENST00000862123.1",
"protein_id": "ENSP00000532182.1",
"transcript_support_level": null,
"aa_start": 589,
"aa_end": null,
"aa_length": 615,
"cds_start": 1766,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862123.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1751G>T",
"hgvs_p": "p.Arg584Leu",
"transcript": "ENST00000862109.1",
"protein_id": "ENSP00000532168.1",
"transcript_support_level": null,
"aa_start": 584,
"aa_end": null,
"aa_length": 610,
"cds_start": 1751,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862109.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1745G>T",
"hgvs_p": "p.Arg582Leu",
"transcript": "ENST00000862103.1",
"protein_id": "ENSP00000532162.1",
"transcript_support_level": null,
"aa_start": 582,
"aa_end": null,
"aa_length": 608,
"cds_start": 1745,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862103.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1736G>T",
"hgvs_p": "p.Arg579Leu",
"transcript": "ENST00000862093.1",
"protein_id": "ENSP00000532152.1",
"transcript_support_level": null,
"aa_start": 579,
"aa_end": null,
"aa_length": 605,
"cds_start": 1736,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862093.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1736G>T",
"hgvs_p": "p.Arg579Leu",
"transcript": "ENST00000862117.1",
"protein_id": "ENSP00000532176.1",
"transcript_support_level": null,
"aa_start": 579,
"aa_end": null,
"aa_length": 605,
"cds_start": 1736,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862117.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1730G>T",
"hgvs_p": "p.Arg577Leu",
"transcript": "ENST00000862095.1",
"protein_id": "ENSP00000532154.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 603,
"cds_start": 1730,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862095.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1724G>T",
"hgvs_p": "p.Arg575Leu",
"transcript": "ENST00000862114.1",
"protein_id": "ENSP00000532173.1",
"transcript_support_level": null,
"aa_start": 575,
"aa_end": null,
"aa_length": 601,
"cds_start": 1724,
"cds_end": null,
"cds_length": 1806,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862114.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1709G>T",
"hgvs_p": "p.Arg570Leu",
"transcript": "ENST00000862101.1",
"protein_id": "ENSP00000532160.1",
"transcript_support_level": null,
"aa_start": 570,
"aa_end": null,
"aa_length": 596,
"cds_start": 1709,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862101.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1703G>T",
"hgvs_p": "p.Arg568Leu",
"transcript": "ENST00000862100.1",
"protein_id": "ENSP00000532159.1",
"transcript_support_level": null,
"aa_start": 568,
"aa_end": null,
"aa_length": 594,
"cds_start": 1703,
"cds_end": null,
"cds_length": 1785,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862100.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1697G>T",
"hgvs_p": "p.Arg566Leu",
"transcript": "ENST00000862098.1",
"protein_id": "ENSP00000532157.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 592,
"cds_start": 1697,
"cds_end": null,
"cds_length": 1779,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862098.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "F2",
"gene_hgnc_id": 3535,
"hgvs_c": "c.1679G>T",
"hgvs_p": "p.Arg560Leu",
"transcript": "ENST00000862099.1",
"protein_id": "ENSP00000532158.1",
"transcript_support_level": null,
"aa_start": 560,
"aa_end": null,
"aa_length": 586,
"cds_start": 1679,
"cds_end": null,
"cds_length": 1761,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
],
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}