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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-47166368-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=47166368&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 47166368,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001410995.1",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1445A>T",
"hgvs_p": "p.Asn482Ile",
"transcript": "NM_032389.6",
"protein_id": "NP_115765.2",
"transcript_support_level": null,
"aa_start": 482,
"aa_end": null,
"aa_length": 521,
"cds_start": 1445,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000524782.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032389.6"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1445A>T",
"hgvs_p": "p.Asn482Ile",
"transcript": "ENST00000524782.6",
"protein_id": "ENSP00000434442.1",
"transcript_support_level": 1,
"aa_start": 482,
"aa_end": null,
"aa_length": 521,
"cds_start": 1445,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032389.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000524782.6"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1562A>T",
"hgvs_p": "p.Asn521Ile",
"transcript": "ENST00000892878.1",
"protein_id": "ENSP00000562937.1",
"transcript_support_level": null,
"aa_start": 521,
"aa_end": null,
"aa_length": 560,
"cds_start": 1562,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892878.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1532A>T",
"hgvs_p": "p.Asn511Ile",
"transcript": "ENST00000946556.1",
"protein_id": "ENSP00000616615.1",
"transcript_support_level": null,
"aa_start": 511,
"aa_end": null,
"aa_length": 550,
"cds_start": 1532,
"cds_end": null,
"cds_length": 1653,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946556.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1529A>T",
"hgvs_p": "p.Asn510Ile",
"transcript": "ENST00000892879.1",
"protein_id": "ENSP00000562938.1",
"transcript_support_level": null,
"aa_start": 510,
"aa_end": null,
"aa_length": 549,
"cds_start": 1529,
"cds_end": null,
"cds_length": 1650,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892879.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1490A>T",
"hgvs_p": "p.Asn497Ile",
"transcript": "ENST00000892889.1",
"protein_id": "ENSP00000562948.1",
"transcript_support_level": null,
"aa_start": 497,
"aa_end": null,
"aa_length": 536,
"cds_start": 1490,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892889.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1487A>T",
"hgvs_p": "p.Asn496Ile",
"transcript": "NM_001410995.1",
"protein_id": "NP_001397924.1",
"transcript_support_level": null,
"aa_start": 496,
"aa_end": null,
"aa_length": 535,
"cds_start": 1487,
"cds_end": null,
"cds_length": 1608,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001410995.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1487A>T",
"hgvs_p": "p.Asn496Ile",
"transcript": "ENST00000525314.6",
"protein_id": "ENSP00000434809.2",
"transcript_support_level": 3,
"aa_start": 496,
"aa_end": null,
"aa_length": 535,
"cds_start": 1487,
"cds_end": null,
"cds_length": 1608,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525314.6"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1439A>T",
"hgvs_p": "p.Asn480Ile",
"transcript": "ENST00000924865.1",
"protein_id": "ENSP00000594924.1",
"transcript_support_level": null,
"aa_start": 480,
"aa_end": null,
"aa_length": 519,
"cds_start": 1439,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924865.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1433A>T",
"hgvs_p": "p.Asn478Ile",
"transcript": "ENST00000892884.1",
"protein_id": "ENSP00000562943.1",
"transcript_support_level": null,
"aa_start": 478,
"aa_end": null,
"aa_length": 517,
"cds_start": 1433,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892884.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1430A>T",
"hgvs_p": "p.Asn477Ile",
"transcript": "ENST00000892885.1",
"protein_id": "ENSP00000562944.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 516,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892885.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1430A>T",
"hgvs_p": "p.Asn477Ile",
"transcript": "ENST00000946554.1",
"protein_id": "ENSP00000616613.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 516,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946554.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1418A>T",
"hgvs_p": "p.Asn473Ile",
"transcript": "ENST00000924867.1",
"protein_id": "ENSP00000594926.1",
"transcript_support_level": null,
"aa_start": 473,
"aa_end": null,
"aa_length": 512,
"cds_start": 1418,
"cds_end": null,
"cds_length": 1539,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924867.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1403A>T",
"hgvs_p": "p.Asn468Ile",
"transcript": "ENST00000892881.1",
"protein_id": "ENSP00000562940.1",
"transcript_support_level": null,
"aa_start": 468,
"aa_end": null,
"aa_length": 507,
"cds_start": 1403,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892881.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1403A>T",
"hgvs_p": "p.Asn468Ile",
"transcript": "ENST00000892883.1",
"protein_id": "ENSP00000562942.1",
"transcript_support_level": null,
"aa_start": 468,
"aa_end": null,
"aa_length": 507,
"cds_start": 1403,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892883.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1388A>T",
"hgvs_p": "p.Asn463Ile",
"transcript": "ENST00000892882.1",
"protein_id": "ENSP00000562941.1",
"transcript_support_level": null,
"aa_start": 463,
"aa_end": null,
"aa_length": 502,
"cds_start": 1388,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892882.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1361A>T",
"hgvs_p": "p.Asn454Ile",
"transcript": "NM_001242832.2",
"protein_id": "NP_001229761.1",
"transcript_support_level": null,
"aa_start": 454,
"aa_end": null,
"aa_length": 493,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001242832.2"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1361A>T",
"hgvs_p": "p.Asn454Ile",
"transcript": "ENST00000426335.6",
"protein_id": "ENSP00000400226.3",
"transcript_support_level": 2,
"aa_start": 454,
"aa_end": null,
"aa_length": 493,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000426335.6"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1358A>T",
"hgvs_p": "p.Asn453Ile",
"transcript": "ENST00000946550.1",
"protein_id": "ENSP00000616609.1",
"transcript_support_level": null,
"aa_start": 453,
"aa_end": null,
"aa_length": 492,
"cds_start": 1358,
"cds_end": null,
"cds_length": 1479,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946550.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1340A>T",
"hgvs_p": "p.Asn447Ile",
"transcript": "ENST00000946552.1",
"protein_id": "ENSP00000616611.1",
"transcript_support_level": null,
"aa_start": 447,
"aa_end": null,
"aa_length": 486,
"cds_start": 1340,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946552.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1316A>T",
"hgvs_p": "p.Asn439Ile",
"transcript": "ENST00000892887.1",
"protein_id": "ENSP00000562946.1",
"transcript_support_level": null,
"aa_start": 439,
"aa_end": null,
"aa_length": 478,
"cds_start": 1316,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892887.1"
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1313A>T",
"hgvs_p": "p.Asn438Ile",
"transcript": "ENST00000892886.1",
"protein_id": "ENSP00000562945.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 477,
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"phenotype_combined": "not specified",
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}
],
"message": null
}