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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-47166876-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=47166876&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 47166876,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001410995.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1216C>G",
"hgvs_p": "p.Arg406Gly",
"transcript": "NM_032389.6",
"protein_id": "NP_115765.2",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 521,
"cds_start": 1216,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 1242,
"cdna_end": null,
"cdna_length": 2773,
"mane_select": "ENST00000524782.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032389.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1216C>G",
"hgvs_p": "p.Arg406Gly",
"transcript": "ENST00000524782.6",
"protein_id": "ENSP00000434442.1",
"transcript_support_level": 1,
"aa_start": 406,
"aa_end": null,
"aa_length": 521,
"cds_start": 1216,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 1242,
"cdna_end": null,
"cdna_length": 2773,
"mane_select": "NM_032389.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000524782.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1333C>G",
"hgvs_p": "p.Arg445Gly",
"transcript": "ENST00000892878.1",
"protein_id": "ENSP00000562937.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 560,
"cds_start": 1333,
"cds_end": null,
"cds_length": 1683,
"cdna_start": 1954,
"cdna_end": null,
"cdna_length": 3485,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892878.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1303C>G",
"hgvs_p": "p.Arg435Gly",
"transcript": "ENST00000946556.1",
"protein_id": "ENSP00000616615.1",
"transcript_support_level": null,
"aa_start": 435,
"aa_end": null,
"aa_length": 550,
"cds_start": 1303,
"cds_end": null,
"cds_length": 1653,
"cdna_start": 1308,
"cdna_end": null,
"cdna_length": 2837,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946556.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1300C>G",
"hgvs_p": "p.Arg434Gly",
"transcript": "ENST00000892879.1",
"protein_id": "ENSP00000562938.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 549,
"cds_start": 1300,
"cds_end": null,
"cds_length": 1650,
"cdna_start": 1911,
"cdna_end": null,
"cdna_length": 3442,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892879.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1261C>G",
"hgvs_p": "p.Arg421Gly",
"transcript": "ENST00000892889.1",
"protein_id": "ENSP00000562948.1",
"transcript_support_level": null,
"aa_start": 421,
"aa_end": null,
"aa_length": 536,
"cds_start": 1261,
"cds_end": null,
"cds_length": 1611,
"cdna_start": 1285,
"cdna_end": null,
"cdna_length": 2813,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892889.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1258C>G",
"hgvs_p": "p.Arg420Gly",
"transcript": "NM_001410995.1",
"protein_id": "NP_001397924.1",
"transcript_support_level": null,
"aa_start": 420,
"aa_end": null,
"aa_length": 535,
"cds_start": 1258,
"cds_end": null,
"cds_length": 1608,
"cdna_start": 1284,
"cdna_end": null,
"cdna_length": 2815,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001410995.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1258C>G",
"hgvs_p": "p.Arg420Gly",
"transcript": "ENST00000525314.6",
"protein_id": "ENSP00000434809.2",
"transcript_support_level": 3,
"aa_start": 420,
"aa_end": null,
"aa_length": 535,
"cds_start": 1258,
"cds_end": null,
"cds_length": 1608,
"cdna_start": 1287,
"cdna_end": null,
"cdna_length": 2747,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525314.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1216C>G",
"hgvs_p": "p.Arg406Gly",
"transcript": "ENST00000924865.1",
"protein_id": "ENSP00000594924.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 519,
"cds_start": 1216,
"cds_end": null,
"cds_length": 1560,
"cdna_start": 1242,
"cdna_end": null,
"cdna_length": 2767,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924865.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1204C>G",
"hgvs_p": "p.Arg402Gly",
"transcript": "ENST00000892884.1",
"protein_id": "ENSP00000562943.1",
"transcript_support_level": null,
"aa_start": 402,
"aa_end": null,
"aa_length": 517,
"cds_start": 1204,
"cds_end": null,
"cds_length": 1554,
"cdna_start": 1230,
"cdna_end": null,
"cdna_length": 2761,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892884.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1201C>G",
"hgvs_p": "p.Arg401Gly",
"transcript": "ENST00000892885.1",
"protein_id": "ENSP00000562944.1",
"transcript_support_level": null,
"aa_start": 401,
"aa_end": null,
"aa_length": 516,
"cds_start": 1201,
"cds_end": null,
"cds_length": 1551,
"cdna_start": 1227,
"cdna_end": null,
"cdna_length": 2758,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892885.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1201C>G",
"hgvs_p": "p.Arg401Gly",
"transcript": "ENST00000946554.1",
"protein_id": "ENSP00000616613.1",
"transcript_support_level": null,
"aa_start": 401,
"aa_end": null,
"aa_length": 516,
"cds_start": 1201,
"cds_end": null,
"cds_length": 1551,
"cdna_start": 1227,
"cdna_end": null,
"cdna_length": 2740,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946554.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1216C>G",
"hgvs_p": "p.Arg406Gly",
"transcript": "ENST00000924867.1",
"protein_id": "ENSP00000594926.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 512,
"cds_start": 1216,
"cds_end": null,
"cds_length": 1539,
"cdna_start": 1230,
"cdna_end": null,
"cdna_length": 2729,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924867.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1174C>G",
"hgvs_p": "p.Arg392Gly",
"transcript": "ENST00000892881.1",
"protein_id": "ENSP00000562940.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 507,
"cds_start": 1174,
"cds_end": null,
"cds_length": 1524,
"cdna_start": 1204,
"cdna_end": null,
"cdna_length": 2735,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892881.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1174C>G",
"hgvs_p": "p.Arg392Gly",
"transcript": "ENST00000892883.1",
"protein_id": "ENSP00000562942.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 507,
"cds_start": 1174,
"cds_end": null,
"cds_length": 1524,
"cdna_start": 1200,
"cdna_end": null,
"cdna_length": 2731,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892883.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1159C>G",
"hgvs_p": "p.Arg387Gly",
"transcript": "ENST00000892882.1",
"protein_id": "ENSP00000562941.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 502,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1509,
"cdna_start": 1185,
"cdna_end": null,
"cdna_length": 2716,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892882.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1132C>G",
"hgvs_p": "p.Arg378Gly",
"transcript": "NM_001242832.2",
"protein_id": "NP_001229761.1",
"transcript_support_level": null,
"aa_start": 378,
"aa_end": null,
"aa_length": 493,
"cds_start": 1132,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 1158,
"cdna_end": null,
"cdna_length": 2689,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001242832.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1132C>G",
"hgvs_p": "p.Arg378Gly",
"transcript": "ENST00000426335.6",
"protein_id": "ENSP00000400226.3",
"transcript_support_level": 2,
"aa_start": 378,
"aa_end": null,
"aa_length": 493,
"cds_start": 1132,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 1404,
"cdna_end": null,
"cdna_length": 2937,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000426335.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1129C>G",
"hgvs_p": "p.Arg377Gly",
"transcript": "ENST00000946550.1",
"protein_id": "ENSP00000616609.1",
"transcript_support_level": null,
"aa_start": 377,
"aa_end": null,
"aa_length": 492,
"cds_start": 1129,
"cds_end": null,
"cds_length": 1479,
"cdna_start": 1152,
"cdna_end": null,
"cdna_length": 2681,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946550.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1111C>G",
"hgvs_p": "p.Arg371Gly",
"transcript": "ENST00000946552.1",
"protein_id": "ENSP00000616611.1",
"transcript_support_level": null,
"aa_start": 371,
"aa_end": null,
"aa_length": 486,
"cds_start": 1111,
"cds_end": null,
"cds_length": 1461,
"cdna_start": 1131,
"cdna_end": null,
"cdna_length": 2660,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946552.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1087C>G",
"hgvs_p": "p.Arg363Gly",
"transcript": "ENST00000892887.1",
"protein_id": "ENSP00000562946.1",
"transcript_support_level": null,
"aa_start": 363,
"aa_end": null,
"aa_length": 478,
"cds_start": 1087,
"cds_end": null,
"cds_length": 1437,
"cdna_start": 1111,
"cdna_end": null,
"cdna_length": 2642,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892887.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP2",
"gene_hgnc_id": 13504,
"hgvs_c": "c.1084C>G",
"hgvs_p": "p.Arg362Gly",
"transcript": "ENST00000892886.1",
"protein_id": "ENSP00000562945.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 477,
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