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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-47743354-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=47743354&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 47743354,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_001441100.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1456+599C>T",
"hgvs_p": null,
"transcript": "NM_015308.5",
"protein_id": "NP_056123.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1017,
"cds_start": null,
"cds_end": null,
"cds_length": 3054,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000263773.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015308.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1456+599C>T",
"hgvs_p": null,
"transcript": "ENST00000263773.10",
"protein_id": "ENSP00000263773.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1017,
"cds_start": null,
"cds_end": null,
"cds_length": 3054,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015308.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000263773.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1681+599C>T",
"hgvs_p": null,
"transcript": "NM_001441100.1",
"protein_id": "NP_001428029.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1092,
"cds_start": null,
"cds_end": null,
"cds_length": 3279,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441100.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1681+599C>T",
"hgvs_p": null,
"transcript": "NM_001441101.1",
"protein_id": "NP_001428030.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1092,
"cds_start": null,
"cds_end": null,
"cds_length": 3279,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441101.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1675+599C>T",
"hgvs_p": null,
"transcript": "NM_001441102.1",
"protein_id": "NP_001428031.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1090,
"cds_start": null,
"cds_end": null,
"cds_length": 3273,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441102.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1675+599C>T",
"hgvs_p": null,
"transcript": "ENST00000917808.1",
"protein_id": "ENSP00000587867.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1090,
"cds_start": null,
"cds_end": null,
"cds_length": 3273,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917808.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1462+599C>T",
"hgvs_p": null,
"transcript": "NM_001318339.4",
"protein_id": "NP_001305268.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1019,
"cds_start": null,
"cds_end": null,
"cds_length": 3060,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001318339.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1462+599C>T",
"hgvs_p": null,
"transcript": "ENST00000883715.1",
"protein_id": "ENSP00000553774.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1019,
"cds_start": null,
"cds_end": null,
"cds_length": 3060,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000883715.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1369+599C>T",
"hgvs_p": null,
"transcript": "NM_001441103.1",
"protein_id": "NP_001428032.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 988,
"cds_start": null,
"cds_end": null,
"cds_length": 2967,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441103.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1363+599C>T",
"hgvs_p": null,
"transcript": "NM_001441104.1",
"protein_id": "NP_001428033.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 986,
"cds_start": null,
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"cds_length": 2961,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441104.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1177+599C>T",
"hgvs_p": null,
"transcript": "NM_001441105.1",
"protein_id": "NP_001428034.1",
"transcript_support_level": null,
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"aa_length": 924,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "NM_001441105.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "FNBP4",
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"transcript": "NM_001441106.1",
"protein_id": "NP_001428035.1",
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"cdna_start": null,
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"mane_select": null,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 5,
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"gene_symbol": "FNBP4",
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"hgvs_c": "c.1006+599C>T",
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"transcript": "NM_001441107.1",
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},
{
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],
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"gene_symbol": "FNBP4",
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"hgvs_c": "c.1462+599C>T",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.906+7562C>T",
"hgvs_p": null,
"transcript": "ENST00000961496.1",
"protein_id": "ENSP00000631555.1",
"transcript_support_level": null,
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"biotype": "protein_coding",
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},
{
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],
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"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1462+599C>T",
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},
{
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1462+599C>T",
"hgvs_p": null,
"transcript": "NM_001441110.1",
"protein_id": "NP_001428039.1",
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"biotype": "protein_coding",
"feature": "NM_001441110.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1456+599C>T",
"hgvs_p": null,
"transcript": "NM_001441111.1",
"protein_id": "NP_001428040.1",
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"cds_start": null,
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},
{
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"consequences": [
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],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "FNBP4",
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"hgvs_c": "c.1456+599C>T",
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},
{
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"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "FNBP4",
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"hgvs_c": "c.1462+599C>T",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 8,
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"gene_symbol": "FNBP4",
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"hgvs_c": "c.1456+599C>T",
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"transcript": "NM_001441114.1",
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"biotype": "protein_coding",
"feature": "NM_001441114.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "FNBP4",
"gene_hgnc_id": 19752,
"hgvs_c": "c.1462+599C>T",
"hgvs_p": null,
"transcript": "XM_047426651.1",
"protein_id": "XP_047282607.1",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047426651.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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}