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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-540782-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=540782&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 540782,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_198075.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "NM_198075.4",
"protein_id": "NP_932341.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000270115.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_198075.4"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000270115.8",
"protein_id": "ENSP00000270115.7",
"transcript_support_level": 1,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_198075.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000270115.8"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "NM_001441283.1",
"protein_id": "NP_001428212.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441283.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "NM_001441284.1",
"protein_id": "NP_001428213.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441284.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886180.1",
"protein_id": "ENSP00000556239.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886180.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886182.1",
"protein_id": "ENSP00000556241.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886182.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886183.1",
"protein_id": "ENSP00000556242.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886183.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886186.1",
"protein_id": "ENSP00000556245.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886186.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000932421.1",
"protein_id": "ENSP00000602480.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932421.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000969148.1",
"protein_id": "ENSP00000639207.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969148.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000969149.1",
"protein_id": "ENSP00000639208.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 542,
"cds_start": 98,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969149.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886187.1",
"protein_id": "ENSP00000556246.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 541,
"cds_start": 98,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886187.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000969151.1",
"protein_id": "ENSP00000639210.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 541,
"cds_start": 98,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969151.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886185.1",
"protein_id": "ENSP00000556244.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 494,
"cds_start": 98,
"cds_end": null,
"cds_length": 1485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886185.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "NM_001441285.1",
"protein_id": "NP_001428214.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 483,
"cds_start": 98,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441285.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "NM_001441286.1",
"protein_id": "NP_001428215.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 483,
"cds_start": 98,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441286.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886181.1",
"protein_id": "ENSP00000556240.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 483,
"cds_start": 98,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886181.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000969150.1",
"protein_id": "ENSP00000639209.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 483,
"cds_start": 98,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969150.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000969152.1",
"protein_id": "ENSP00000639211.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 483,
"cds_start": 98,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969152.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000969153.1",
"protein_id": "ENSP00000639212.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 483,
"cds_start": 98,
"cds_end": null,
"cds_length": 1452,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969153.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000886184.1",
"protein_id": "ENSP00000556243.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 478,
"cds_start": 98,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000886184.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC56",
"gene_hgnc_id": 25430,
"hgvs_c": "c.98C>G",
"hgvs_p": "p.Pro33Arg",
"transcript": "ENST00000932420.1",
"protein_id": "ENSP00000602479.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 458,
"cds_start": 98,
"cds_end": null,
"cds_length": 1377,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932420.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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}