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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-57491278-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=57491278&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 57491278,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_003627.6",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "NM_003627.6",
"protein_id": "NP_003618.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000278426.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003627.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000278426.8",
"protein_id": "ENSP00000278426.3",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003627.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000278426.8"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000528450.5",
"protein_id": "ENSP00000435673.1",
"transcript_support_level": 1,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000528450.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1241G>T",
"hgvs_p": "p.Arg414Leu",
"transcript": "ENST00000901382.1",
"protein_id": "ENSP00000571441.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 593,
"cds_start": 1241,
"cds_end": null,
"cds_length": 1782,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901382.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1241G>T",
"hgvs_p": "p.Arg414Leu",
"transcript": "ENST00000901385.1",
"protein_id": "ENSP00000571444.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 593,
"cds_start": 1241,
"cds_end": null,
"cds_length": 1782,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901385.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1241G>T",
"hgvs_p": "p.Arg414Leu",
"transcript": "ENST00000967928.1",
"protein_id": "ENSP00000637987.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 593,
"cds_start": 1241,
"cds_end": null,
"cds_length": 1782,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967928.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1178G>T",
"hgvs_p": "p.Arg393Leu",
"transcript": "ENST00000967929.1",
"protein_id": "ENSP00000637988.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 572,
"cds_start": 1178,
"cds_end": null,
"cds_length": 1719,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967929.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "NM_001198810.2",
"protein_id": "NP_001185739.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001198810.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000901383.1",
"protein_id": "ENSP00000571442.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901383.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000901388.1",
"protein_id": "ENSP00000571447.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901388.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000901389.1",
"protein_id": "ENSP00000571448.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901389.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000930672.1",
"protein_id": "ENSP00000600731.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930672.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000930673.1",
"protein_id": "ENSP00000600732.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930673.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000967930.1",
"protein_id": "ENSP00000637989.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 559,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967930.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000930670.1",
"protein_id": "ENSP00000600729.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 550,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1653,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930670.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1139G>T",
"hgvs_p": "p.Arg380Leu",
"transcript": "ENST00000901381.1",
"protein_id": "ENSP00000571440.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 549,
"cds_start": 1139,
"cds_end": null,
"cds_length": 1650,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901381.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1103G>T",
"hgvs_p": "p.Arg368Leu",
"transcript": "ENST00000901378.1",
"protein_id": "ENSP00000571437.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 547,
"cds_start": 1103,
"cds_end": null,
"cds_length": 1644,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901378.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1103G>T",
"hgvs_p": "p.Arg368Leu",
"transcript": "ENST00000901387.1",
"protein_id": "ENSP00000571446.1",
"transcript_support_level": null,
"aa_start": 368,
"aa_end": null,
"aa_length": 547,
"cds_start": 1103,
"cds_end": null,
"cds_length": 1644,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901387.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1046G>T",
"hgvs_p": "p.Arg349Leu",
"transcript": "ENST00000901380.1",
"protein_id": "ENSP00000571439.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 528,
"cds_start": 1046,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901380.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1046G>T",
"hgvs_p": "p.Arg349Leu",
"transcript": "ENST00000901386.1",
"protein_id": "ENSP00000571445.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 528,
"cds_start": 1046,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901386.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1046G>T",
"hgvs_p": "p.Arg349Leu",
"transcript": "ENST00000930674.1",
"protein_id": "ENSP00000600733.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 528,
"cds_start": 1046,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930674.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC43A1",
"gene_hgnc_id": 9225,
"hgvs_c": "c.1046G>T",
"hgvs_p": "p.Arg349Leu",
"transcript": "ENST00000930675.1",
"protein_id": "ENSP00000600734.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 528,
"cds_start": 1046,
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