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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-59152680-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=59152680&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 59152680,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_022074.4",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001312909.2",
"protein_id": "NP_001299838.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000675163.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001312909.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "ENST00000675163.1",
"protein_id": "ENSP00000501952.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001312909.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000675163.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "ENST00000531147.1",
"protein_id": "ENSP00000431631.1",
"transcript_support_level": 1,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000531147.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001142519.3",
"protein_id": "NP_001135991.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001142519.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001142520.3",
"protein_id": "NP_001135992.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001142520.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001142521.3",
"protein_id": "NP_001135993.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001142521.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001312910.2",
"protein_id": "NP_001299839.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001312910.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001312911.2",
"protein_id": "NP_001299840.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001312911.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001369457.1",
"protein_id": "NP_001356386.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369457.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374804.1",
"protein_id": "NP_001361733.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374804.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374848.1",
"protein_id": "NP_001361777.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374848.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374849.1",
"protein_id": "NP_001361778.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374849.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374850.1",
"protein_id": "NP_001361779.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374850.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374851.1",
"protein_id": "NP_001361780.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374851.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374852.1",
"protein_id": "NP_001361781.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374852.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374853.1",
"protein_id": "NP_001361782.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374853.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374854.1",
"protein_id": "NP_001361783.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374854.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374855.1",
"protein_id": "NP_001361784.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374855.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374856.1",
"protein_id": "NP_001361785.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374856.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374857.1",
"protein_id": "NP_001361786.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374857.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374858.1",
"protein_id": "NP_001361787.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374858.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FAM111A",
"gene_hgnc_id": 24725,
"hgvs_c": "c.1012A>G",
"hgvs_p": "p.Thr338Ala",
"transcript": "NM_001374859.1",
"protein_id": "NP_001361788.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 611,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
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