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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-61359386-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=61359386&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 4,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "CYB561A3",
          "hgnc_id": 23014,
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": -2,
          "transcript": "NM_001300763.2",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_score": -2,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.83,
      "chr": "11",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.8299999833106995,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2584,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_153611.6",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000294072.9",
          "protein_coding": true,
          "protein_id": "NP_705839.3",
          "strand": false,
          "transcript": "NM_153611.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2584,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000294072.9",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_153611.6",
          "protein_coding": true,
          "protein_id": "ENSP00000294072.4",
          "strand": false,
          "transcript": "ENST00000294072.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1494,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000540755.5",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "n.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000445561.1",
          "strand": false,
          "transcript": "ENST00000540755.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 181,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4094,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 547,
          "cds_start": null,
          "consequences": [
            "5_prime_UTR_premature_start_codon_gain_variant"
          ],
          "exon_count": 4,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000537364.5",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-1669G>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000438725.1",
          "strand": false,
          "transcript": "ENST00000537364.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 181,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4094,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 547,
          "cds_start": null,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_count": 4,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000537364.5",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-1669G>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000438725.1",
          "strand": false,
          "transcript": "ENST00000537364.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 263,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1865,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 792,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001300763.2",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001287692.1",
          "strand": false,
          "transcript": "NM_001300763.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 263,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1803,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 792,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000447532.6",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000389745.2",
          "strand": false,
          "transcript": "ENST00000447532.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 259,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3211,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 780,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001161454.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-229-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001154926.1",
          "strand": false,
          "transcript": "NM_001161454.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 259,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3205,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 780,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000426130.6",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-229-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000398979.2",
          "strand": false,
          "transcript": "ENST00000426130.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2940,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884217.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-16+2347G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554276.1",
          "strand": false,
          "transcript": "ENST00000884217.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2983,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884218.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-62-1607G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554277.1",
          "strand": false,
          "transcript": "ENST00000884218.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3129,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884219.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554278.1",
          "strand": false,
          "transcript": "ENST00000884219.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2957,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884220.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554279.1",
          "strand": false,
          "transcript": "ENST00000884220.1",
          "transcript_support_level": null
        },
        {
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          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2680,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884221.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554280.1",
          "strand": false,
          "transcript": "ENST00000884221.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2581,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884222.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-108-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554281.1",
          "strand": false,
          "transcript": "ENST00000884222.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2667,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000884223.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554282.1",
          "strand": false,
          "transcript": "ENST00000884223.1",
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        },
        {
          "aa_alt": null,
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          "aa_length": 242,
          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2951,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000945361.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615420.1",
          "strand": false,
          "transcript": "ENST00000945361.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
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          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
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          "cdna_length": 3360,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000945362.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-111-1558G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615421.1",
          "strand": false,
          "transcript": "ENST00000945362.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 242,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2891,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 729,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000945363.1",
          "gene_hgnc_id": 23014,
          "gene_symbol": "CYB561A3",
          "hgvs_c": "c.-16+2354G>T",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615422.1",
          "strand": false,
          "transcript": "ENST00000945363.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
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}
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