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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-61766136-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=61766136&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 61766136,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001127392.3",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "NM_001127392.3",
"protein_id": "NP_001120864.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1151,
"cds_start": 313,
"cds_end": null,
"cds_length": 3456,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000278836.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127392.3"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000278836.10",
"protein_id": "ENSP00000278836.4",
"transcript_support_level": 1,
"aa_start": 105,
"aa_end": null,
"aa_length": 1151,
"cds_start": 313,
"cds_end": null,
"cds_length": 3456,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001127392.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000278836.10"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.286A>G",
"hgvs_p": "p.Asn96Asp",
"transcript": "ENST00000265460.9",
"protein_id": "ENSP00000265460.5",
"transcript_support_level": 1,
"aa_start": 96,
"aa_end": null,
"aa_length": 1111,
"cds_start": 286,
"cds_end": null,
"cds_length": 3336,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265460.9"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856811.1",
"protein_id": "ENSP00000526870.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1152,
"cds_start": 313,
"cds_end": null,
"cds_length": 3459,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856811.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856806.1",
"protein_id": "ENSP00000526865.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1147,
"cds_start": 313,
"cds_end": null,
"cds_length": 3444,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856806.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856800.1",
"protein_id": "ENSP00000526859.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1146,
"cds_start": 313,
"cds_end": null,
"cds_length": 3441,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856800.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856799.1",
"protein_id": "ENSP00000526858.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1125,
"cds_start": 313,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856799.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856812.1",
"protein_id": "ENSP00000526871.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1124,
"cds_start": 313,
"cds_end": null,
"cds_length": 3375,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856812.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856803.1",
"protein_id": "ENSP00000526862.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1120,
"cds_start": 313,
"cds_end": null,
"cds_length": 3363,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856803.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856801.1",
"protein_id": "ENSP00000526860.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1119,
"cds_start": 313,
"cds_end": null,
"cds_length": 3360,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856801.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856808.1",
"protein_id": "ENSP00000526867.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1112,
"cds_start": 313,
"cds_end": null,
"cds_length": 3339,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856808.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.286A>G",
"hgvs_p": "p.Asn96Asp",
"transcript": "NM_013279.4",
"protein_id": "NP_037411.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 1111,
"cds_start": 286,
"cds_end": null,
"cds_length": 3336,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_013279.4"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856810.1",
"protein_id": "ENSP00000526869.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1109,
"cds_start": 313,
"cds_end": null,
"cds_length": 3330,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856810.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000918479.1",
"protein_id": "ENSP00000588538.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1108,
"cds_start": 313,
"cds_end": null,
"cds_length": 3327,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918479.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856804.1",
"protein_id": "ENSP00000526863.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1096,
"cds_start": 313,
"cds_end": null,
"cds_length": 3291,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856804.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856798.1",
"protein_id": "ENSP00000526857.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1095,
"cds_start": 313,
"cds_end": null,
"cds_length": 3288,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856798.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856802.1",
"protein_id": "ENSP00000526861.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1069,
"cds_start": 313,
"cds_end": null,
"cds_length": 3210,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856802.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856809.1",
"protein_id": "ENSP00000526868.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1068,
"cds_start": 313,
"cds_end": null,
"cds_length": 3207,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856809.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000918478.1",
"protein_id": "ENSP00000588537.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1057,
"cds_start": 313,
"cds_end": null,
"cds_length": 3174,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918478.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856805.1",
"protein_id": "ENSP00000526864.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1032,
"cds_start": 313,
"cds_end": null,
"cds_length": 3099,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856805.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856813.1",
"protein_id": "ENSP00000526872.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1021,
"cds_start": 313,
"cds_end": null,
"cds_length": 3066,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856813.1"
},
{
"aa_ref": "N",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.313A>G",
"hgvs_p": "p.Asn105Asp",
"transcript": "ENST00000856807.1",
"protein_id": "ENSP00000526866.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 1020,
"cds_start": 313,
"cds_end": null,
"cds_length": 3063,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
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}