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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-61785208-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=61785208&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 61785208,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001127392.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3301-592G>C",
"hgvs_p": null,
"transcript": "NM_001127392.3",
"protein_id": "NP_001120864.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1151,
"cds_start": null,
"cds_end": null,
"cds_length": 3456,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5940,
"mane_select": "ENST00000278836.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127392.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3301-592G>C",
"hgvs_p": null,
"transcript": "ENST00000278836.10",
"protein_id": "ENSP00000278836.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1151,
"cds_start": null,
"cds_end": null,
"cds_length": 3456,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5940,
"mane_select": "NM_001127392.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000278836.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3181-592G>C",
"hgvs_p": null,
"transcript": "ENST00000265460.9",
"protein_id": "ENSP00000265460.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1111,
"cds_start": null,
"cds_end": null,
"cds_length": 3336,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5745,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265460.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "n.3022G>C",
"hgvs_p": null,
"transcript": "ENST00000539361.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3324,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000539361.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3304-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856811.1",
"protein_id": "ENSP00000526870.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1152,
"cds_start": null,
"cds_end": null,
"cds_length": 3459,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5920,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856811.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3289-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856806.1",
"protein_id": "ENSP00000526865.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1147,
"cds_start": null,
"cds_end": null,
"cds_length": 3444,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5934,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856806.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3286-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856800.1",
"protein_id": "ENSP00000526859.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1146,
"cds_start": null,
"cds_end": null,
"cds_length": 3441,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5943,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856800.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3223-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856799.1",
"protein_id": "ENSP00000526858.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1125,
"cds_start": null,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5905,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856799.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3220-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856812.1",
"protein_id": "ENSP00000526871.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1124,
"cds_start": null,
"cds_end": null,
"cds_length": 3375,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5836,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856812.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3208-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856803.1",
"protein_id": "ENSP00000526862.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1120,
"cds_start": null,
"cds_end": null,
"cds_length": 3363,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5857,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856803.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3205-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856801.1",
"protein_id": "ENSP00000526860.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1119,
"cds_start": null,
"cds_end": null,
"cds_length": 3360,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5862,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856801.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3184-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856808.1",
"protein_id": "ENSP00000526867.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1112,
"cds_start": null,
"cds_end": null,
"cds_length": 3339,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5823,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856808.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3181-592G>C",
"hgvs_p": null,
"transcript": "NM_013279.4",
"protein_id": "NP_037411.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1111,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": 5757,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_013279.4"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3175-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856810.1",
"protein_id": "ENSP00000526869.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856810.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3172-592G>C",
"hgvs_p": null,
"transcript": "ENST00000918479.1",
"protein_id": "ENSP00000588538.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1108,
"cds_start": null,
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"cds_length": 3327,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918479.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3136-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856804.1",
"protein_id": "ENSP00000526863.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856804.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3133-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856798.1",
"protein_id": "ENSP00000526857.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1095,
"cds_start": null,
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"cds_length": 3288,
"cdna_start": null,
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"cdna_length": 5815,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856798.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3055-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856802.1",
"protein_id": "ENSP00000526861.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1069,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000856802.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3052-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856809.1",
"protein_id": "ENSP00000526868.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000856809.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.3019-592G>C",
"hgvs_p": null,
"transcript": "ENST00000918478.1",
"protein_id": "ENSP00000588537.1",
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000918478.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.2944-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856805.1",
"protein_id": "ENSP00000526864.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1032,
"cds_start": null,
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"cds_length": 3099,
"cdna_start": null,
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"cdna_length": 5591,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856805.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "MYRF",
"gene_hgnc_id": 1181,
"hgvs_c": "c.2911-592G>C",
"hgvs_p": null,
"transcript": "ENST00000856813.1",
"protein_id": "ENSP00000526872.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1021,
"cds_start": null,
"cds_end": null,
"cds_length": 3066,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5526,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856813.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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{
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"BP4_Strong"
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{
"score": -2,
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"verdict": "Likely_benign",
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],
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}