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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-64224329-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=64224329&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 64224329,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000317459.11",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "NM_001033678.4",
"protein_id": "NP_001028850.2",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 253,
"cds_start": 515,
"cds_end": null,
"cds_length": 762,
"cdna_start": 661,
"cdna_end": null,
"cdna_length": 968,
"mane_select": "ENST00000317459.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "ENST00000317459.11",
"protein_id": "ENSP00000314073.6",
"transcript_support_level": 1,
"aa_start": 172,
"aa_end": null,
"aa_length": 253,
"cds_start": 515,
"cds_end": null,
"cds_length": 762,
"cdna_start": 661,
"cdna_end": null,
"cdna_length": 968,
"mane_select": "NM_001033678.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.368A>T",
"hgvs_p": "p.His123Leu",
"transcript": "ENST00000394547.7",
"protein_id": "ENSP00000378051.3",
"transcript_support_level": 1,
"aa_start": 123,
"aa_end": null,
"aa_length": 204,
"cds_start": 368,
"cds_end": null,
"cds_length": 615,
"cdna_start": 541,
"cdna_end": null,
"cdna_length": 865,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.521A>T",
"hgvs_p": "p.His174Leu",
"transcript": "NM_001160389.2",
"protein_id": "NP_001153861.1",
"transcript_support_level": null,
"aa_start": 174,
"aa_end": null,
"aa_length": 255,
"cds_start": 521,
"cds_end": null,
"cds_length": 768,
"cdna_start": 667,
"cdna_end": null,
"cdna_length": 974,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.521A>T",
"hgvs_p": "p.His174Leu",
"transcript": "ENST00000394546.6",
"protein_id": "ENSP00000378050.2",
"transcript_support_level": 5,
"aa_start": 174,
"aa_end": null,
"aa_length": 255,
"cds_start": 521,
"cds_end": null,
"cds_length": 768,
"cdna_start": 735,
"cdna_end": null,
"cdna_length": 1058,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "NM_001160393.1",
"protein_id": "NP_001153865.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 254,
"cds_start": 515,
"cds_end": null,
"cds_length": 765,
"cdna_start": 524,
"cdna_end": null,
"cdna_length": 851,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "NM_001160390.2",
"protein_id": "NP_001153862.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 253,
"cds_start": 515,
"cds_end": null,
"cds_length": 762,
"cdna_start": 649,
"cdna_end": null,
"cdna_length": 956,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "NM_001160392.2",
"protein_id": "NP_001153864.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 216,
"cds_start": 515,
"cds_end": null,
"cds_length": 651,
"cdna_start": 661,
"cdna_end": null,
"cdna_length": 857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "ENST00000541278.5",
"protein_id": "ENSP00000438683.1",
"transcript_support_level": 2,
"aa_start": 172,
"aa_end": null,
"aa_length": 216,
"cds_start": 515,
"cds_end": null,
"cds_length": 651,
"cdna_start": 729,
"cdna_end": null,
"cdna_length": 941,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.368A>T",
"hgvs_p": "p.His123Leu",
"transcript": "NM_031472.4",
"protein_id": "NP_113660.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 204,
"cds_start": 368,
"cds_end": null,
"cds_length": 615,
"cdna_start": 577,
"cdna_end": null,
"cdna_length": 884,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.521A>T",
"hgvs_p": "p.His174Leu",
"transcript": "ENST00000545812.1",
"protein_id": "ENSP00000442066.1",
"transcript_support_level": 3,
"aa_start": 174,
"aa_end": null,
"aa_length": 190,
"cds_start": 521,
"cds_end": null,
"cds_length": 573,
"cdna_start": 629,
"cdna_end": null,
"cdna_length": 681,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.368A>T",
"hgvs_p": "p.His123Leu",
"transcript": "NM_001330298.2",
"protein_id": "NP_001317227.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 167,
"cds_start": 368,
"cds_end": null,
"cds_length": 504,
"cdna_start": 577,
"cdna_end": null,
"cdna_length": 773,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.368A>T",
"hgvs_p": "p.His123Leu",
"transcript": "ENST00000546089.5",
"protein_id": "ENSP00000437741.1",
"transcript_support_level": 3,
"aa_start": 123,
"aa_end": null,
"aa_length": 167,
"cds_start": 368,
"cds_end": null,
"cds_length": 504,
"cdna_start": 525,
"cdna_end": null,
"cdna_length": 684,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.104A>T",
"hgvs_p": "p.His35Leu",
"transcript": "ENST00000544286.5",
"protein_id": "ENSP00000445292.1",
"transcript_support_level": 2,
"aa_start": 35,
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"cds_start": 104,
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"cdna_start": 105,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 2,
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"exon_count": 4,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.137A>T",
"hgvs_p": "p.His46Leu",
"transcript": "ENST00000546133.5",
"protein_id": "ENSP00000439586.1",
"transcript_support_level": 2,
"aa_start": 46,
"aa_end": null,
"aa_length": 111,
"cds_start": 137,
"cds_end": null,
"cds_length": 336,
"cdna_start": 137,
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"cdna_length": 382,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "XM_005274345.5",
"protein_id": "XP_005274402.1",
"transcript_support_level": null,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "XM_005274346.5",
"protein_id": "XP_005274403.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
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"cds_start": 515,
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"cdna_start": 613,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "XM_006718707.4",
"protein_id": "XP_006718770.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 254,
"cds_start": 515,
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"cdna_start": 571,
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"cdna_length": 898,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "XM_024448708.2",
"protein_id": "XP_024304476.1",
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},
{
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"protein_coding": true,
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"consequences": [
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],
"exon_rank": 6,
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "XM_024448709.2",
"protein_id": "XP_024304477.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
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"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
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"transcript": "XM_047427679.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.515A>T",
"hgvs_p": "p.His172Leu",
"transcript": "XM_047427680.1",
"protein_id": "XP_047283636.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 216,
"cds_start": 515,
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"cdna_start": 649,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPT1",
"gene_hgnc_id": 20316,
"hgvs_c": "c.368A>T",
"hgvs_p": "p.His123Leu",
"transcript": "XM_005274347.5",
"protein_id": "XP_005274404.1",
"transcript_support_level": null,
"aa_start": 123,
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}
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}