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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-6431723-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=6431723&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 6431723,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_000613.3",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1047C>G",
"hgvs_p": "p.Val349Val",
"transcript": "NM_000613.3",
"protein_id": "NP_000604.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 462,
"cds_start": 1047,
"cds_end": null,
"cds_length": 1389,
"cdna_start": 1071,
"cdna_end": null,
"cdna_length": 1575,
"mane_select": "ENST00000265983.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000613.3"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1047C>G",
"hgvs_p": "p.Val349Val",
"transcript": "ENST00000265983.8",
"protein_id": "ENSP00000265983.3",
"transcript_support_level": 1,
"aa_start": 349,
"aa_end": null,
"aa_length": 462,
"cds_start": 1047,
"cds_end": null,
"cds_length": 1389,
"cdna_start": 1071,
"cdna_end": null,
"cdna_length": 1575,
"mane_select": "NM_000613.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265983.8"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1044C>G",
"hgvs_p": "p.Val348Val",
"transcript": "ENST00000868746.1",
"protein_id": "ENSP00000538805.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 461,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 1135,
"cdna_end": null,
"cdna_length": 1682,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868746.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1038C>G",
"hgvs_p": "p.Val346Val",
"transcript": "ENST00000868752.1",
"protein_id": "ENSP00000538811.1",
"transcript_support_level": null,
"aa_start": 346,
"aa_end": null,
"aa_length": 459,
"cds_start": 1038,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 1129,
"cdna_end": null,
"cdna_length": 1640,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868752.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1035C>G",
"hgvs_p": "p.Val345Val",
"transcript": "ENST00000868750.1",
"protein_id": "ENSP00000538809.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 458,
"cds_start": 1035,
"cds_end": null,
"cds_length": 1377,
"cdna_start": 1135,
"cdna_end": null,
"cdna_length": 1646,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868750.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1017C>G",
"hgvs_p": "p.Val339Val",
"transcript": "ENST00000868773.1",
"protein_id": "ENSP00000538832.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 452,
"cds_start": 1017,
"cds_end": null,
"cds_length": 1359,
"cdna_start": 1044,
"cdna_end": null,
"cdna_length": 1544,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868773.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1014C>G",
"hgvs_p": "p.Val338Val",
"transcript": "ENST00000868753.1",
"protein_id": "ENSP00000538812.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 451,
"cds_start": 1014,
"cds_end": null,
"cds_length": 1356,
"cdna_start": 1105,
"cdna_end": null,
"cdna_length": 1616,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868753.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1047C>G",
"hgvs_p": "p.Val349Val",
"transcript": "ENST00000868755.1",
"protein_id": "ENSP00000538814.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 451,
"cds_start": 1047,
"cds_end": null,
"cds_length": 1356,
"cdna_start": 1096,
"cdna_end": null,
"cdna_length": 1565,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868755.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.1011C>G",
"hgvs_p": "p.Val337Val",
"transcript": "ENST00000868768.1",
"protein_id": "ENSP00000538827.1",
"transcript_support_level": null,
"aa_start": 337,
"aa_end": null,
"aa_length": 450,
"cds_start": 1011,
"cds_end": null,
"cds_length": 1353,
"cdna_start": 1038,
"cdna_end": null,
"cdna_length": 1540,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868768.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.975C>G",
"hgvs_p": "p.Val325Val",
"transcript": "ENST00000868760.1",
"protein_id": "ENSP00000538819.1",
"transcript_support_level": null,
"aa_start": 325,
"aa_end": null,
"aa_length": 438,
"cds_start": 975,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 1004,
"cdna_end": null,
"cdna_length": 1514,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868760.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.951C>G",
"hgvs_p": "p.Val317Val",
"transcript": "ENST00000868751.1",
"protein_id": "ENSP00000538810.1",
"transcript_support_level": null,
"aa_start": 317,
"aa_end": null,
"aa_length": 430,
"cds_start": 951,
"cds_end": null,
"cds_length": 1293,
"cdna_start": 1042,
"cdna_end": null,
"cdna_length": 1553,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868751.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.915C>G",
"hgvs_p": "p.Val305Val",
"transcript": "ENST00000868757.1",
"protein_id": "ENSP00000538816.1",
"transcript_support_level": null,
"aa_start": 305,
"aa_end": null,
"aa_length": 418,
"cds_start": 915,
"cds_end": null,
"cds_length": 1257,
"cdna_start": 944,
"cdna_end": null,
"cdna_length": 1465,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868757.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.903C>G",
"hgvs_p": "p.Val301Val",
"transcript": "ENST00000868756.1",
"protein_id": "ENSP00000538815.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 414,
"cds_start": 903,
"cds_end": null,
"cds_length": 1245,
"cdna_start": 952,
"cdna_end": null,
"cdna_length": 1454,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868756.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.888C>G",
"hgvs_p": "p.Val296Val",
"transcript": "ENST00000868761.1",
"protein_id": "ENSP00000538820.1",
"transcript_support_level": null,
"aa_start": 296,
"aa_end": null,
"aa_length": 409,
"cds_start": 888,
"cds_end": null,
"cds_length": 1230,
"cdna_start": 915,
"cdna_end": null,
"cdna_length": 1426,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868761.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.870C>G",
"hgvs_p": "p.Val290Val",
"transcript": "ENST00000868759.1",
"protein_id": "ENSP00000538818.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 403,
"cds_start": 870,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 899,
"cdna_end": null,
"cdna_length": 1410,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868759.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.867C>G",
"hgvs_p": "p.Val289Val",
"transcript": "ENST00000868770.1",
"protein_id": "ENSP00000538829.1",
"transcript_support_level": null,
"aa_start": 289,
"aa_end": null,
"aa_length": 402,
"cds_start": 867,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 894,
"cdna_end": null,
"cdna_length": 1396,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868770.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.834C>G",
"hgvs_p": "p.Val278Val",
"transcript": "ENST00000868748.1",
"protein_id": "ENSP00000538807.1",
"transcript_support_level": null,
"aa_start": 278,
"aa_end": null,
"aa_length": 391,
"cds_start": 834,
"cds_end": null,
"cds_length": 1176,
"cdna_start": 934,
"cdna_end": null,
"cdna_length": 1455,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868748.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.825C>G",
"hgvs_p": "p.Val275Val",
"transcript": "ENST00000868765.1",
"protein_id": "ENSP00000538824.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 388,
"cds_start": 825,
"cds_end": null,
"cds_length": 1167,
"cdna_start": 852,
"cdna_end": null,
"cdna_length": 1358,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868765.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.777C>G",
"hgvs_p": "p.Val259Val",
"transcript": "ENST00000868754.1",
"protein_id": "ENSP00000538813.1",
"transcript_support_level": null,
"aa_start": 259,
"aa_end": null,
"aa_length": 372,
"cds_start": 777,
"cds_end": null,
"cds_length": 1119,
"cdna_start": 833,
"cdna_end": null,
"cdna_length": 1345,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868754.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.771C>G",
"hgvs_p": "p.Val257Val",
"transcript": "ENST00000868745.1",
"protein_id": "ENSP00000538804.1",
"transcript_support_level": null,
"aa_start": 257,
"aa_end": null,
"aa_length": 370,
"cds_start": 771,
"cds_end": null,
"cds_length": 1113,
"cdna_start": 935,
"cdna_end": null,
"cdna_length": 1446,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868745.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.762C>G",
"hgvs_p": "p.Val254Val",
"transcript": "ENST00000868758.1",
"protein_id": "ENSP00000538817.1",
"transcript_support_level": null,
"aa_start": 254,
"aa_end": null,
"aa_length": 367,
"cds_start": 762,
"cds_end": null,
"cds_length": 1104,
"cdna_start": 792,
"cdna_end": null,
"cdna_length": 1303,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868758.1"
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HPX",
"gene_hgnc_id": 5171,
"hgvs_c": "c.732C>G",
"hgvs_p": "p.Val244Val",
"transcript": "ENST00000868775.1",
"protein_id": "ENSP00000538834.1",
"transcript_support_level": null,
"aa_start": 244,
"aa_end": null,
"aa_length": 357,
"cds_start": 732,
"cds_end": null,
"cds_length": 1074,
"cdna_start": 742,
"cdna_end": null,
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