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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-65128410-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=65128410&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 65128410,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_172230.3",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1826A>C",
"hgvs_p": "p.Gln609Pro",
"transcript": "NM_172230.3",
"protein_id": "NP_757385.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 617,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 1907,
"cdna_end": null,
"cdna_length": 3038,
"mane_select": "ENST00000377190.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_172230.3"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1826A>C",
"hgvs_p": "p.Gln609Pro",
"transcript": "ENST00000377190.8",
"protein_id": "ENSP00000366395.3",
"transcript_support_level": 1,
"aa_start": 609,
"aa_end": null,
"aa_length": 617,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 1907,
"cdna_end": null,
"cdna_length": 3038,
"mane_select": "NM_172230.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377190.8"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1823A>C",
"hgvs_p": "p.Gln608Pro",
"transcript": "ENST00000294256.12",
"protein_id": "ENSP00000294256.8",
"transcript_support_level": 1,
"aa_start": 608,
"aa_end": null,
"aa_length": 616,
"cds_start": 1823,
"cds_end": null,
"cds_length": 1851,
"cdna_start": 1917,
"cdna_end": null,
"cdna_length": 3048,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000294256.12"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1670A>C",
"hgvs_p": "p.Gln557Pro",
"transcript": "ENST00000307289.10",
"protein_id": "ENSP00000302035.6",
"transcript_support_level": 1,
"aa_start": 557,
"aa_end": null,
"aa_length": 565,
"cds_start": 1670,
"cds_end": null,
"cds_length": 1698,
"cdna_start": 1712,
"cdna_end": null,
"cdna_length": 2841,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000307289.10"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1841A>C",
"hgvs_p": "p.Gln614Pro",
"transcript": "ENST00000904693.1",
"protein_id": "ENSP00000574752.1",
"transcript_support_level": null,
"aa_start": 614,
"aa_end": null,
"aa_length": 622,
"cds_start": 1841,
"cds_end": null,
"cds_length": 1869,
"cdna_start": 1948,
"cdna_end": null,
"cdna_length": 3080,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904693.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1838A>C",
"hgvs_p": "p.Gln613Pro",
"transcript": "ENST00000904692.1",
"protein_id": "ENSP00000574751.1",
"transcript_support_level": null,
"aa_start": 613,
"aa_end": null,
"aa_length": 621,
"cds_start": 1838,
"cds_end": null,
"cds_length": 1866,
"cdna_start": 1930,
"cdna_end": null,
"cdna_length": 3090,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904692.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1826A>C",
"hgvs_p": "p.Gln609Pro",
"transcript": "ENST00000904688.1",
"protein_id": "ENSP00000574747.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 617,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 1926,
"cdna_end": null,
"cdna_length": 3057,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904688.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1826A>C",
"hgvs_p": "p.Gln609Pro",
"transcript": "ENST00000904689.1",
"protein_id": "ENSP00000574748.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 617,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 2096,
"cdna_end": null,
"cdna_length": 3230,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904689.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1826A>C",
"hgvs_p": "p.Gln609Pro",
"transcript": "ENST00000904690.1",
"protein_id": "ENSP00000574749.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 617,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 2404,
"cdna_end": null,
"cdna_length": 3537,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904690.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1826A>C",
"hgvs_p": "p.Gln609Pro",
"transcript": "ENST00000904704.1",
"protein_id": "ENSP00000574763.1",
"transcript_support_level": null,
"aa_start": 609,
"aa_end": null,
"aa_length": 617,
"cds_start": 1826,
"cds_end": null,
"cds_length": 1854,
"cdna_start": 1868,
"cdna_end": null,
"cdna_length": 3001,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904704.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1823A>C",
"hgvs_p": "p.Gln608Pro",
"transcript": "NM_032431.3",
"protein_id": "NP_115807.1",
"transcript_support_level": null,
"aa_start": 608,
"aa_end": null,
"aa_length": 616,
"cds_start": 1823,
"cds_end": null,
"cds_length": 1851,
"cdna_start": 1904,
"cdna_end": null,
"cdna_length": 3035,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032431.3"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1823A>C",
"hgvs_p": "p.Gln608Pro",
"transcript": "ENST00000526060.5",
"protein_id": "ENSP00000436984.1",
"transcript_support_level": 5,
"aa_start": 608,
"aa_end": null,
"aa_length": 616,
"cds_start": 1823,
"cds_end": null,
"cds_length": 1851,
"cdna_start": 2016,
"cdna_end": null,
"cdna_length": 3144,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000526060.5"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1823A>C",
"hgvs_p": "p.Gln608Pro",
"transcript": "ENST00000904691.1",
"protein_id": "ENSP00000574750.1",
"transcript_support_level": null,
"aa_start": 608,
"aa_end": null,
"aa_length": 616,
"cds_start": 1823,
"cds_end": null,
"cds_length": 1851,
"cdna_start": 2093,
"cdna_end": null,
"cdna_length": 3211,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904691.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1823A>C",
"hgvs_p": "p.Gln608Pro",
"transcript": "ENST00000904697.1",
"protein_id": "ENSP00000574756.1",
"transcript_support_level": null,
"aa_start": 608,
"aa_end": null,
"aa_length": 616,
"cds_start": 1823,
"cds_end": null,
"cds_length": 1851,
"cdna_start": 1939,
"cdna_end": null,
"cdna_length": 3067,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904697.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1814A>C",
"hgvs_p": "p.Gln605Pro",
"transcript": "ENST00000904694.1",
"protein_id": "ENSP00000574753.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 613,
"cds_start": 1814,
"cds_end": null,
"cds_length": 1842,
"cdna_start": 1911,
"cdna_end": null,
"cdna_length": 3043,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904694.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1811A>C",
"hgvs_p": "p.Gln604Pro",
"transcript": "ENST00000904701.1",
"protein_id": "ENSP00000574760.1",
"transcript_support_level": null,
"aa_start": 604,
"aa_end": null,
"aa_length": 612,
"cds_start": 1811,
"cds_end": null,
"cds_length": 1839,
"cdna_start": 1889,
"cdna_end": null,
"cdna_length": 3015,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904701.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1802A>C",
"hgvs_p": "p.Gln601Pro",
"transcript": "ENST00000904702.1",
"protein_id": "ENSP00000574761.1",
"transcript_support_level": null,
"aa_start": 601,
"aa_end": null,
"aa_length": 609,
"cds_start": 1802,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1861,
"cdna_end": null,
"cdna_length": 2994,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904702.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1796A>C",
"hgvs_p": "p.Gln599Pro",
"transcript": "ENST00000904695.1",
"protein_id": "ENSP00000574754.1",
"transcript_support_level": null,
"aa_start": 599,
"aa_end": null,
"aa_length": 607,
"cds_start": 1796,
"cds_end": null,
"cds_length": 1824,
"cdna_start": 1893,
"cdna_end": null,
"cdna_length": 3024,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904695.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1793A>C",
"hgvs_p": "p.Gln598Pro",
"transcript": "ENST00000904700.1",
"protein_id": "ENSP00000574759.1",
"transcript_support_level": null,
"aa_start": 598,
"aa_end": null,
"aa_length": 606,
"cds_start": 1793,
"cds_end": null,
"cds_length": 1821,
"cdna_start": 1868,
"cdna_end": null,
"cdna_length": 3000,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904700.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1790A>C",
"hgvs_p": "p.Gln597Pro",
"transcript": "ENST00000904703.1",
"protein_id": "ENSP00000574762.1",
"transcript_support_level": null,
"aa_start": 597,
"aa_end": null,
"aa_length": 605,
"cds_start": 1790,
"cds_end": null,
"cds_length": 1818,
"cdna_start": 1849,
"cdna_end": null,
"cdna_length": 2980,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904703.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1781A>C",
"hgvs_p": "p.Gln594Pro",
"transcript": "ENST00000904705.1",
"protein_id": "ENSP00000574764.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 602,
"cds_start": 1781,
"cds_end": null,
"cds_length": 1809,
"cdna_start": 1829,
"cdna_end": null,
"cdna_length": 2955,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904705.1"
},
{
"aa_ref": "Q",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYVN1",
"gene_hgnc_id": 20738,
"hgvs_c": "c.1760A>C",
"hgvs_p": "p.Gln587Pro",
"transcript": "ENST00000904698.1",
"protein_id": "ENSP00000574757.1",
"transcript_support_level": null,
"aa_start": 587,
"aa_end": null,
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"cds_start": 1760,
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{
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}