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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-65539080-T-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=65539080&ref=T&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PM4",
            "PP5_Moderate"
          ],
          "effects": [
            "stop_lost"
          ],
          "gene_symbol": "LTBP3",
          "hgnc_id": 6716,
          "hgvs_c": "c.3912A>T",
          "hgvs_p": "p.Ter1304Cysext*?",
          "inheritance_mode": "AD,AR",
          "pathogenic_score": 6,
          "score": 6,
          "transcript": "NM_001130144.3",
          "verdict": "Likely_pathogenic"
        }
      ],
      "acmg_classification": "Likely_pathogenic",
      "acmg_criteria": "PM2,PM4,PP5_Moderate",
      "acmg_score": 6,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.1,
      "chr": "11",
      "clinvar_classification": "Pathogenic",
      "clinvar_disease": "Geleophysic dysplasia 3",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "P:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.10000000149011612,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1303,
          "aa_ref": "*",
          "aa_start": 1304,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4833,
          "cdna_start": 4312,
          "cds_end": null,
          "cds_length": 3912,
          "cds_start": 3912,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 28,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "NM_001130144.3",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3912A>T",
          "hgvs_p": "p.Ter1304Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000301873.11",
          "protein_coding": true,
          "protein_id": "NP_001123616.1",
          "strand": false,
          "transcript": "NM_001130144.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1303,
          "aa_ref": "*",
          "aa_start": 1304,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 4833,
          "cdna_start": 4312,
          "cds_end": null,
          "cds_length": 3912,
          "cds_start": 3912,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 28,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000301873.11",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3912A>T",
          "hgvs_p": "p.Ter1304Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001130144.3",
          "protein_coding": true,
          "protein_id": "ENSP00000301873.5",
          "strand": false,
          "transcript": "ENST00000301873.11",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1256,
          "aa_ref": "*",
          "aa_start": 1257,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4046,
          "cdna_start": 3771,
          "cds_end": null,
          "cds_length": 3771,
          "cds_start": 3771,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000322147.8",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3771A>T",
          "hgvs_p": "p.Ter1257Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000326647.4",
          "strand": false,
          "transcript": "ENST00000322147.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3935,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000528516.5",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "n.*3416A>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000432350.1",
          "strand": false,
          "transcript": "ENST00000528516.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3935,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000528516.5",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "n.*3416A>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000432350.1",
          "strand": false,
          "transcript": "ENST00000528516.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1312,
          "aa_ref": "*",
          "aa_start": 1313,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4540,
          "cdna_start": 4278,
          "cds_end": null,
          "cds_length": 3939,
          "cds_start": 3939,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 28,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000971648.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3939A>T",
          "hgvs_p": "p.Ter1313Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000641707.1",
          "strand": false,
          "transcript": "ENST00000971648.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1302,
          "aa_ref": "*",
          "aa_start": 1303,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4580,
          "cdna_start": 4312,
          "cds_end": null,
          "cds_length": 3909,
          "cds_start": 3909,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 28,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000971647.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3909A>T",
          "hgvs_p": "p.Ter1303Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000641706.1",
          "strand": false,
          "transcript": "ENST00000971647.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1273,
          "aa_ref": "*",
          "aa_start": 1274,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4324,
          "cdna_start": 4063,
          "cds_end": null,
          "cds_length": 3822,
          "cds_start": 3822,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 26,
          "exon_rank": 26,
          "exon_rank_end": null,
          "feature": "ENST00000971650.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3822A>T",
          "hgvs_p": "p.Ter1274Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000641709.1",
          "strand": false,
          "transcript": "ENST00000971650.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1262,
          "aa_ref": "*",
          "aa_start": 1263,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4710,
          "cdna_start": 4189,
          "cds_end": null,
          "cds_length": 3789,
          "cds_start": 3789,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000689505.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3789A>T",
          "hgvs_p": "p.Ter1263Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000510401.1",
          "strand": false,
          "transcript": "ENST00000689505.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1262,
          "aa_ref": "*",
          "aa_start": 1263,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4649,
          "cdna_start": 4128,
          "cds_end": null,
          "cds_length": 3789,
          "cds_start": 3789,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000971646.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3789A>T",
          "hgvs_p": "p.Ter1263Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000641705.1",
          "strand": false,
          "transcript": "ENST00000971646.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1262,
          "aa_ref": "*",
          "aa_start": 1263,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4383,
          "cdna_start": 4122,
          "cds_end": null,
          "cds_length": 3789,
          "cds_start": 3789,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000971649.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3789A>T",
          "hgvs_p": "p.Ter1263Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000641708.1",
          "strand": false,
          "transcript": "ENST00000971649.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1256,
          "aa_ref": "*",
          "aa_start": 1257,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4561,
          "cdna_start": 4040,
          "cds_end": null,
          "cds_length": 3771,
          "cds_start": 3771,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "NM_021070.4",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3771A>T",
          "hgvs_p": "p.Ter1257Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_066548.2",
          "strand": false,
          "transcript": "NM_021070.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1214,
          "aa_ref": "*",
          "aa_start": 1215,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4512,
          "cdna_start": 3991,
          "cds_end": null,
          "cds_length": 3645,
          "cds_start": 3645,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 29,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000530866.6",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3645A>T",
          "hgvs_p": "p.Ter1215Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000435276.2",
          "strand": false,
          "transcript": "ENST00000530866.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 1139,
          "aa_ref": "*",
          "aa_start": 1140,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4557,
          "cdna_start": 4036,
          "cds_end": null,
          "cds_length": 3420,
          "cds_start": 3420,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "NM_001164266.1",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.3420A>T",
          "hgvs_p": "p.Ter1140Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001157738.1",
          "strand": false,
          "transcript": "NM_001164266.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 971,
          "aa_ref": "*",
          "aa_start": 972,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3344,
          "cdna_start": 3316,
          "cds_end": null,
          "cds_length": 2916,
          "cds_start": 2916,
          "consequences": [
            "stop_lost"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000526927.6",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.2916A>T",
          "hgvs_p": "p.Ter972Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000431219.2",
          "strand": false,
          "transcript": "ENST00000526927.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "C",
          "aa_end": null,
          "aa_length": 259,
          "aa_ref": "*",
          "aa_start": 260,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 863,
          "cdna_start": 863,
          "cds_end": null,
          "cds_length": 780,
          "cds_start": 780,
          "consequences": [
            "stop_lost",
            "splice_region_variant"
          ],
          "exon_count": 6,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000532661.6",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "c.780A>T",
          "hgvs_p": "p.Ter260Cysext*?",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000436341.2",
          "strand": false,
          "transcript": "ENST00000532661.6",
          "transcript_support_level": 3
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4498,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 27,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000526825.6",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "n.*3175A>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000435146.2",
          "strand": false,
          "transcript": "ENST00000526825.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1997,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 12,
          "exon_rank": 12,
          "exon_rank_end": null,
          "feature": "ENST00000529189.5",
          "gene_hgnc_id": 6716,
          "gene_symbol": "LTBP3",
          "hgvs_c": "n.1736A>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000529189.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2464,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 10,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000529582.6",
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.