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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-65661693-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=65661693&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 65661693,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001404657.1",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "NM_021975.4",
"protein_id": "NP_068810.3",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 551,
"cds_start": 329,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000406246.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021975.4"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000406246.8",
"protein_id": "ENSP00000384273.3",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 551,
"cds_start": 329,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021975.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000406246.8"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000308639.13",
"protein_id": "ENSP00000311508.9",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 548,
"cds_start": 329,
"cds_end": null,
"cds_length": 1647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000308639.13"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000612991.4",
"protein_id": "ENSP00000483705.1",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 448,
"cds_start": 329,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000612991.4"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000525693.5",
"protein_id": "ENSP00000432537.1",
"transcript_support_level": 1,
"aa_start": 110,
"aa_end": null,
"aa_length": 377,
"cds_start": 329,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525693.5"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.362T>C",
"hgvs_p": "p.Ile121Thr",
"transcript": "NM_001404657.1",
"protein_id": "NP_001391586.1",
"transcript_support_level": null,
"aa_start": 121,
"aa_end": null,
"aa_length": 562,
"cds_start": 362,
"cds_end": null,
"cds_length": 1689,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404657.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "NM_001145138.2",
"protein_id": "NP_001138610.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 548,
"cds_start": 329,
"cds_end": null,
"cds_length": 1647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145138.2"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.302T>C",
"hgvs_p": "p.Ile101Thr",
"transcript": "NM_001404658.1",
"protein_id": "NP_001391587.1",
"transcript_support_level": null,
"aa_start": 101,
"aa_end": null,
"aa_length": 542,
"cds_start": 302,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404658.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000931854.1",
"protein_id": "ENSP00000601913.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 541,
"cds_start": 329,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931854.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.236T>C",
"hgvs_p": "p.Ile79Thr",
"transcript": "NM_001404662.1",
"protein_id": "NP_001391591.1",
"transcript_support_level": null,
"aa_start": 79,
"aa_end": null,
"aa_length": 520,
"cds_start": 236,
"cds_end": null,
"cds_length": 1563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404662.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.236T>C",
"hgvs_p": "p.Ile79Thr",
"transcript": "NM_001404663.1",
"protein_id": "NP_001391592.1",
"transcript_support_level": null,
"aa_start": 79,
"aa_end": null,
"aa_length": 520,
"cds_start": 236,
"cds_end": null,
"cds_length": 1563,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404663.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000959966.1",
"protein_id": "ENSP00000630025.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 516,
"cds_start": 329,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959966.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000878957.1",
"protein_id": "ENSP00000549016.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 514,
"cds_start": 329,
"cds_end": null,
"cds_length": 1545,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878957.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "NM_001243984.2",
"protein_id": "NP_001230913.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 482,
"cds_start": 329,
"cds_end": null,
"cds_length": 1449,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243984.2"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "NM_001404659.1",
"protein_id": "NP_001391588.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 480,
"cds_start": 329,
"cds_end": null,
"cds_length": 1443,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404659.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000931853.1",
"protein_id": "ENSP00000601912.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 480,
"cds_start": 329,
"cds_end": null,
"cds_length": 1443,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931853.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "NM_001243985.2",
"protein_id": "NP_001230914.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 448,
"cds_start": 329,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243985.2"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "NM_001404660.1",
"protein_id": "NP_001391589.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 445,
"cds_start": 329,
"cds_end": null,
"cds_length": 1338,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404660.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.329T>C",
"hgvs_p": "p.Ile110Thr",
"transcript": "ENST00000959967.1",
"protein_id": "ENSP00000630026.1",
"transcript_support_level": null,
"aa_start": 110,
"aa_end": null,
"aa_length": 431,
"cds_start": 329,
"cds_end": null,
"cds_length": 1296,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959967.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.40T>C",
"hgvs_p": "p.Ser14Pro",
"transcript": "NM_001404661.1",
"protein_id": "NP_001391590.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 424,
"cds_start": 40,
"cds_end": null,
"cds_length": 1275,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001404661.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.362T>C",
"hgvs_p": "p.Ile121Thr",
"transcript": "ENST00000532999.5",
"protein_id": "ENSP00000433526.1",
"transcript_support_level": 5,
"aa_start": 121,
"aa_end": null,
"aa_length": 417,
"cds_start": 362,
"cds_end": null,
"cds_length": 1255,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000532999.5"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RELA",
"gene_hgnc_id": 9955,
"hgvs_c": "c.302T>C",
"hgvs_p": "p.Ile101Thr",
"transcript": "ENST00000534558.5",
"protein_id": "ENSP00000434372.1",
"transcript_support_level": 5,
"aa_start": 101,
"aa_end": null,
"aa_length": 207,
"cds_start": 302,
"cds_end": null,
"cds_length": 625,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000534558.5"
},
{
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}
],
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}