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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-66509105-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=66509105&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "DPP3",
          "hgnc_id": 3008,
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "NM_005700.5",
          "verdict": "Benign"
        },
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "5_prime_UTR_variant"
          ],
          "gene_symbol": "ENSG00000256349",
          "hgnc_id": null,
          "hgvs_c": "c.-52G>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "ENST00000419755.3",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_score": -12,
      "allele_count_reference_population": 47302,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1454,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.14,
      "chr": "11",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.0016162097454071045,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2660,
          "cdna_start": 2108,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_130443.4",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000531863.6",
          "protein_coding": true,
          "protein_id": "NP_569710.2",
          "strand": true,
          "transcript": "NM_130443.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2660,
          "cdna_start": 2108,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000531863.6",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_130443.4",
          "protein_coding": true,
          "protein_id": "ENSP00000432782.2",
          "strand": true,
          "transcript": "ENST00000531863.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 756,
          "aa_ref": "E",
          "aa_start": 709,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3078,
          "cdna_start": 2526,
          "cds_end": null,
          "cds_length": 2271,
          "cds_start": 2125,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000532677.5",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2125G>A",
          "hgvs_p": "p.Glu709Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000435284.1",
          "strand": true,
          "transcript": "ENST00000532677.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 630,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3547,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1893,
          "cds_start": null,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_count": 17,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000419755.3",
          "gene_hgnc_id": null,
          "gene_symbol": "ENSG00000256349",
          "hgvs_c": "c.-52G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000398526.3",
          "strand": true,
          "transcript": "ENST00000419755.3",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 757,
          "aa_ref": "E",
          "aa_start": 710,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2711,
          "cdna_start": 2161,
          "cds_end": null,
          "cds_length": 2274,
          "cds_start": 2128,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000883964.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2128G>A",
          "hgvs_p": "p.Glu710Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554023.1",
          "strand": true,
          "transcript": "ENST00000883964.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 745,
          "aa_ref": "E",
          "aa_start": 698,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2682,
          "cdna_start": 2128,
          "cds_end": null,
          "cds_length": 2238,
          "cds_start": 2092,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000883960.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2092G>A",
          "hgvs_p": "p.Glu698Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554019.1",
          "strand": true,
          "transcript": "ENST00000883960.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 745,
          "aa_ref": "E",
          "aa_start": 698,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2679,
          "cdna_start": 2125,
          "cds_end": null,
          "cds_length": 2238,
          "cds_start": 2092,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000914253.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2092G>A",
          "hgvs_p": "p.Glu698Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584312.1",
          "strand": true,
          "transcript": "ENST00000914253.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 741,
          "aa_ref": "E",
          "aa_start": 694,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2666,
          "cdna_start": 2116,
          "cds_end": null,
          "cds_length": 2226,
          "cds_start": 2080,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000883963.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2080G>A",
          "hgvs_p": "p.Glu694Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554022.1",
          "strand": true,
          "transcript": "ENST00000883963.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 741,
          "aa_ref": "E",
          "aa_start": 694,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2666,
          "cdna_start": 2115,
          "cds_end": null,
          "cds_length": 2226,
          "cds_start": 2080,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000962696.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2080G>A",
          "hgvs_p": "p.Glu694Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000632755.1",
          "strand": true,
          "transcript": "ENST00000962696.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2657,
          "cdna_start": 2105,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_005700.5",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_005691.2",
          "strand": true,
          "transcript": "NM_005700.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2676,
          "cdna_start": 2124,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000541961.5",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000440502.1",
          "strand": true,
          "transcript": "ENST00000541961.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2710,
          "cdna_start": 2158,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000883957.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554016.1",
          "strand": true,
          "transcript": "ENST00000883957.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2769,
          "cdna_start": 2208,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000914249.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584308.1",
          "strand": true,
          "transcript": "ENST00000914249.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 737,
          "aa_ref": "E",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3187,
          "cdna_start": 2635,
          "cds_end": null,
          "cds_length": 2214,
          "cds_start": 2068,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000914254.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2068G>A",
          "hgvs_p": "p.Glu690Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584313.1",
          "strand": true,
          "transcript": "ENST00000914254.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 735,
          "aa_ref": "E",
          "aa_start": 688,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2655,
          "cdna_start": 2102,
          "cds_end": null,
          "cds_length": 2208,
          "cds_start": 2062,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000883958.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2062G>A",
          "hgvs_p": "p.Glu688Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554017.1",
          "strand": true,
          "transcript": "ENST00000883958.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 735,
          "aa_ref": "E",
          "aa_start": 688,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2650,
          "cdna_start": 2098,
          "cds_end": null,
          "cds_length": 2208,
          "cds_start": 2062,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000883961.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2062G>A",
          "hgvs_p": "p.Glu688Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000554020.1",
          "strand": true,
          "transcript": "ENST00000883961.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 733,
          "aa_ref": "E",
          "aa_start": 686,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2653,
          "cdna_start": 2101,
          "cds_end": null,
          "cds_length": 2202,
          "cds_start": 2056,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000914250.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2056G>A",
          "hgvs_p": "p.Glu686Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584309.1",
          "strand": true,
          "transcript": "ENST00000914250.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 733,
          "aa_ref": "E",
          "aa_start": 686,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2650,
          "cdna_start": 2098,
          "cds_end": null,
          "cds_length": 2202,
          "cds_start": 2056,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000914252.1",
          "gene_hgnc_id": 3008,
          "gene_symbol": "DPP3",
          "hgvs_c": "c.2056G>A",
          "hgvs_p": "p.Glu686Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000584311.1",
          "strand": true,
          "transcript": "ENST00000914252.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 716,
          "aa_ref": "E",
          "aa_start": 669,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.