← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-70161378-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=70161378&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 70161378,
      "ref": "C",
      "alt": "G",
      "effect": "intron_variant",
      "transcript": "ENST00000355303.10",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1780+16C>G",
          "hgvs_p": null,
          "transcript": "NM_018043.7",
          "protein_id": "NP_060513.5",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 986,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2961,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4777,
          "mane_select": "ENST00000355303.10",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1780+16C>G",
          "hgvs_p": null,
          "transcript": "ENST00000355303.10",
          "protein_id": "ENSP00000347454.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 986,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2961,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4777,
          "mane_select": "NM_018043.7",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": 19,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1969+16C>G",
          "hgvs_p": null,
          "transcript": "ENST00000531349.6",
          "protein_id": "ENSP00000432843.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1049,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3150,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4878,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": 19,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1969+16C>G",
          "hgvs_p": null,
          "transcript": "NM_001378092.1",
          "protein_id": "NP_001365021.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1049,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3150,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4878,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1768+16C>G",
          "hgvs_p": null,
          "transcript": "NM_001378093.1",
          "protein_id": "NP_001365022.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 982,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2949,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4613,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1768+16C>G",
          "hgvs_p": null,
          "transcript": "NM_001378094.2",
          "protein_id": "NP_001365023.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 982,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2949,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4765,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1768+16C>G",
          "hgvs_p": null,
          "transcript": "NM_001378095.2",
          "protein_id": "NP_001365024.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 982,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2949,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4765,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1690+16C>G",
          "hgvs_p": null,
          "transcript": "NM_001378096.2",
          "protein_id": "NP_001365025.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 956,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2871,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4687,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1603+16C>G",
          "hgvs_p": null,
          "transcript": "NM_001378097.2",
          "protein_id": "NP_001365026.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4600,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1342+16C>G",
          "hgvs_p": null,
          "transcript": "ENST00000530676.5",
          "protein_id": "ENSP00000435797.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 840,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2523,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3289,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1606+16C>G",
          "hgvs_p": null,
          "transcript": "ENST00000316296.9",
          "protein_id": "ENSP00000319477.5",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 642,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1929,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2118,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.433+16C>G",
          "hgvs_p": null,
          "transcript": "ENST00000531300.1",
          "protein_id": "ENSP00000435868.1",
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 150,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 454,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 577,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": 11,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "n.1123+16C>G",
          "hgvs_p": null,
          "transcript": "ENST00000689710.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3552,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "n.1835+16C>G",
          "hgvs_p": null,
          "transcript": "NR_030691.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3571,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1879+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427181.1",
          "protein_id": "XP_047283137.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1019,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3060,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4788,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": 19,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1846+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427182.1",
          "protein_id": "XP_047283138.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1008,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3027,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4691,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": 19,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1846+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427183.1",
          "protein_id": "XP_047283139.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1008,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3027,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4726,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1843+16C>G",
          "hgvs_p": null,
          "transcript": "XM_011545123.3",
          "protein_id": "XP_011543425.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1007,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3024,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4615,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1837+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427185.1",
          "protein_id": "XP_047283141.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1005,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3018,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5111,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 17,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1834+16C>G",
          "hgvs_p": null,
          "transcript": "XM_011545124.3",
          "protein_id": "XP_011543426.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1004,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 3015,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4606,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1813+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427184.1",
          "protein_id": "XP_047283140.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 997,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2994,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4722,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1780+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427186.1",
          "protein_id": "XP_047283142.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 986,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2961,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4625,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1762+16C>G",
          "hgvs_p": null,
          "transcript": "XM_006718602.3",
          "protein_id": "XP_006718665.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 980,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2943,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4570,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1759+16C>G",
          "hgvs_p": null,
          "transcript": "XM_011545129.3",
          "protein_id": "XP_011543431.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 979,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2940,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4567,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1702+16C>G",
          "hgvs_p": null,
          "transcript": "XM_011545127.3",
          "protein_id": "XP_011543429.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 960,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2883,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4474,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": 12,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.985+16C>G",
          "hgvs_p": null,
          "transcript": "XM_047427187.1",
          "protein_id": "XP_047283143.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 721,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2166,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3745,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 15,
          "intron_rank_end": null,
          "gene_symbol": "ANO1",
          "gene_hgnc_id": 21625,
          "hgvs_c": "c.1606+16C>G",
          "hgvs_p": null,
          "transcript": "XM_011545131.3",
          "protein_id": "XP_011543433.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 642,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1929,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2242,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "ANO1",
      "gene_hgnc_id": 21625,
      "dbsnp": "rs2276068",
      "frequency_reference_population": 0.5227329,
      "hom_count_reference_population": 223894,
      "allele_count_reference_population": 842588,
      "gnomad_exomes_af": 0.526802,
      "gnomad_genomes_af": 0.483681,
      "gnomad_exomes_ac": 769024,
      "gnomad_genomes_ac": 73564,
      "gnomad_exomes_homalt": 205274,
      "gnomad_genomes_homalt": 18620,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.8299999833106995,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.83,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.238,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -12,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -12,
          "benign_score": 12,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000355303.10",
          "gene_symbol": "ANO1",
          "hgnc_id": 21625,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AR,AD",
          "hgvs_c": "c.1780+16C>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}