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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-72293375-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=72293375&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 72293375,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_030813.6",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2116A>C",
"hgvs_p": "p.Thr706Pro",
"transcript": "NM_030813.6",
"protein_id": "NP_110440.1",
"transcript_support_level": null,
"aa_start": 706,
"aa_end": null,
"aa_length": 707,
"cds_start": 2116,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 2173,
"cdna_end": null,
"cdna_length": 10053,
"mane_select": null,
"mane_plus": "ENST00000294053.9",
"biotype": "protein_coding",
"feature": "NM_030813.6"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2116A>C",
"hgvs_p": "p.Thr706Pro",
"transcript": "ENST00000294053.9",
"protein_id": "ENSP00000294053.3",
"transcript_support_level": 1,
"aa_start": 706,
"aa_end": null,
"aa_length": 707,
"cds_start": 2116,
"cds_end": null,
"cds_length": 2124,
"cdna_start": 2173,
"cdna_end": null,
"cdna_length": 10053,
"mane_select": null,
"mane_plus": "NM_030813.6",
"biotype": "protein_coding",
"feature": "ENST00000294053.9"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2026A>C",
"hgvs_p": "p.Thr676Pro",
"transcript": "NM_001258392.3",
"protein_id": "NP_001245321.1",
"transcript_support_level": null,
"aa_start": 676,
"aa_end": null,
"aa_length": 677,
"cds_start": 2026,
"cds_end": null,
"cds_length": 2034,
"cdna_start": 2083,
"cdna_end": null,
"cdna_length": 9963,
"mane_select": "ENST00000538039.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001258392.3"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2026A>C",
"hgvs_p": "p.Thr676Pro",
"transcript": "ENST00000538039.6",
"protein_id": "ENSP00000441518.1",
"transcript_support_level": 2,
"aa_start": 676,
"aa_end": null,
"aa_length": 677,
"cds_start": 2026,
"cds_end": null,
"cds_length": 2034,
"cdna_start": 2083,
"cdna_end": null,
"cdna_length": 9963,
"mane_select": "NM_001258392.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000538039.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "n.*815A>C",
"hgvs_p": null,
"transcript": "ENST00000538021.5",
"protein_id": "ENSP00000445180.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1108,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000538021.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "n.*815A>C",
"hgvs_p": null,
"transcript": "ENST00000538021.5",
"protein_id": "ENSP00000445180.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1108,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000538021.5"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2089A>C",
"hgvs_p": "p.Thr697Pro",
"transcript": "ENST00000955687.1",
"protein_id": "ENSP00000625746.1",
"transcript_support_level": null,
"aa_start": 697,
"aa_end": null,
"aa_length": 698,
"cds_start": 2089,
"cds_end": null,
"cds_length": 2097,
"cdna_start": 2141,
"cdna_end": null,
"cdna_length": 2218,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955687.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2071A>C",
"hgvs_p": "p.Thr691Pro",
"transcript": "ENST00000543042.6",
"protein_id": "ENSP00000439746.2",
"transcript_support_level": 2,
"aa_start": 691,
"aa_end": null,
"aa_length": 692,
"cds_start": 2071,
"cds_end": null,
"cds_length": 2079,
"cdna_start": 2204,
"cdna_end": null,
"cdna_length": 2276,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000543042.6"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2059A>C",
"hgvs_p": "p.Thr687Pro",
"transcript": "ENST00000955683.1",
"protein_id": "ENSP00000625742.1",
"transcript_support_level": null,
"aa_start": 687,
"aa_end": null,
"aa_length": 688,
"cds_start": 2059,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 2142,
"cdna_end": null,
"cdna_length": 3230,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955683.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2056A>C",
"hgvs_p": "p.Thr686Pro",
"transcript": "ENST00000866362.1",
"protein_id": "ENSP00000536421.1",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 687,
"cds_start": 2056,
"cds_end": null,
"cds_length": 2064,
"cdna_start": 2088,
"cdna_end": null,
"cdna_length": 3160,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866362.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2056A>C",
"hgvs_p": "p.Thr686Pro",
"transcript": "ENST00000866363.1",
"protein_id": "ENSP00000536422.1",
"transcript_support_level": null,
"aa_start": 686,
"aa_end": null,
"aa_length": 687,
"cds_start": 2056,
"cds_end": null,
"cds_length": 2064,
"cdna_start": 2133,
"cdna_end": null,
"cdna_length": 2359,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866363.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2023A>C",
"hgvs_p": "p.Thr675Pro",
"transcript": "ENST00000955688.1",
"protein_id": "ENSP00000625747.1",
"transcript_support_level": null,
"aa_start": 675,
"aa_end": null,
"aa_length": 676,
"cds_start": 2023,
"cds_end": null,
"cds_length": 2031,
"cdna_start": 2073,
"cdna_end": null,
"cdna_length": 2150,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955688.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2011A>C",
"hgvs_p": "p.Thr671Pro",
"transcript": "ENST00000955686.1",
"protein_id": "ENSP00000625745.1",
"transcript_support_level": null,
"aa_start": 671,
"aa_end": null,
"aa_length": 672,
"cds_start": 2011,
"cds_end": null,
"cds_length": 2019,
"cdna_start": 2076,
"cdna_end": null,
"cdna_length": 2153,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955686.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1981A>C",
"hgvs_p": "p.Thr661Pro",
"transcript": "NM_001258394.3",
"protein_id": "NP_001245323.1",
"transcript_support_level": null,
"aa_start": 661,
"aa_end": null,
"aa_length": 662,
"cds_start": 1981,
"cds_end": null,
"cds_length": 1989,
"cdna_start": 2280,
"cdna_end": null,
"cdna_length": 10160,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001258394.3"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1948A>C",
"hgvs_p": "p.Thr650Pro",
"transcript": "ENST00000938927.1",
"protein_id": "ENSP00000608986.1",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 651,
"cds_start": 1948,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2002,
"cdna_end": null,
"cdna_length": 2076,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938927.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1939A>C",
"hgvs_p": "p.Thr647Pro",
"transcript": "NM_001258393.3",
"protein_id": "NP_001245322.1",
"transcript_support_level": null,
"aa_start": 647,
"aa_end": null,
"aa_length": 648,
"cds_start": 1939,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1996,
"cdna_end": null,
"cdna_length": 9876,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001258393.3"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1939A>C",
"hgvs_p": "p.Thr647Pro",
"transcript": "ENST00000340729.9",
"protein_id": "ENSP00000340385.5",
"transcript_support_level": 2,
"aa_start": 647,
"aa_end": null,
"aa_length": 648,
"cds_start": 1939,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 1999,
"cdna_end": null,
"cdna_length": 2071,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000340729.9"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1906A>C",
"hgvs_p": "p.Thr636Pro",
"transcript": "ENST00000955685.1",
"protein_id": "ENSP00000625744.1",
"transcript_support_level": null,
"aa_start": 636,
"aa_end": null,
"aa_length": 637,
"cds_start": 1906,
"cds_end": null,
"cds_length": 1914,
"cdna_start": 1989,
"cdna_end": null,
"cdna_length": 2065,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955685.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1897A>C",
"hgvs_p": "p.Thr633Pro",
"transcript": "ENST00000955684.1",
"protein_id": "ENSP00000625743.1",
"transcript_support_level": null,
"aa_start": 633,
"aa_end": null,
"aa_length": 634,
"cds_start": 1897,
"cds_end": null,
"cds_length": 1905,
"cdna_start": 1956,
"cdna_end": null,
"cdna_length": 2067,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955684.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1714A>C",
"hgvs_p": "p.Thr572Pro",
"transcript": "ENST00000866364.1",
"protein_id": "ENSP00000536423.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 573,
"cds_start": 1714,
"cds_end": null,
"cds_length": 1722,
"cdna_start": 1771,
"cdna_end": null,
"cdna_length": 1875,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866364.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.2029A>C",
"hgvs_p": "p.Thr677Pro",
"transcript": "XM_005274320.2",
"protein_id": "XP_005274377.1",
"transcript_support_level": null,
"aa_start": 677,
"aa_end": null,
"aa_length": 678,
"cds_start": 2029,
"cds_end": null,
"cds_length": 2037,
"cdna_start": 2086,
"cdna_end": null,
"cdna_length": 9966,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005274320.2"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLPB",
"gene_hgnc_id": 30664,
"hgvs_c": "c.1891A>C",
"hgvs_p": "p.Thr631Pro",
"transcript": "XM_047427655.1",
"protein_id": "XP_047283611.1",
"transcript_support_level": null,
"aa_start": 631,
"aa_end": null,
"aa_length": 632,
"cds_start": 1891,
"cds_end": null,
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}
],
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}