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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-72329709-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=72329709&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 72329709,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant,splice_region_variant",
      "transcript": "ENST00000538039.6",
      "consequences": [
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.961A>G",
          "hgvs_p": "p.Lys321Glu",
          "transcript": "NM_030813.6",
          "protein_id": "NP_110440.1",
          "transcript_support_level": null,
          "aa_start": 321,
          "aa_end": null,
          "aa_length": 707,
          "cds_start": 961,
          "cds_end": null,
          "cds_length": 2124,
          "cdna_start": 1018,
          "cdna_end": null,
          "cdna_length": 10053,
          "mane_select": null,
          "mane_plus": "ENST00000294053.9",
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.961A>G",
          "hgvs_p": "p.Lys321Glu",
          "transcript": "ENST00000294053.9",
          "protein_id": "ENSP00000294053.3",
          "transcript_support_level": 1,
          "aa_start": 321,
          "aa_end": null,
          "aa_length": 707,
          "cds_start": 961,
          "cds_end": null,
          "cds_length": 2124,
          "cdna_start": 1018,
          "cdna_end": null,
          "cdna_length": 10053,
          "mane_select": null,
          "mane_plus": "NM_030813.6",
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.871A>G",
          "hgvs_p": "p.Lys291Glu",
          "transcript": "NM_001258392.3",
          "protein_id": "NP_001245321.1",
          "transcript_support_level": null,
          "aa_start": 291,
          "aa_end": null,
          "aa_length": 677,
          "cds_start": 871,
          "cds_end": null,
          "cds_length": 2034,
          "cdna_start": 928,
          "cdna_end": null,
          "cdna_length": 9963,
          "mane_select": "ENST00000538039.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.871A>G",
          "hgvs_p": "p.Lys291Glu",
          "transcript": "ENST00000538039.6",
          "protein_id": "ENSP00000441518.1",
          "transcript_support_level": 2,
          "aa_start": 291,
          "aa_end": null,
          "aa_length": 677,
          "cds_start": 871,
          "cds_end": null,
          "cds_length": 2034,
          "cdna_start": 928,
          "cdna_end": null,
          "cdna_length": 9963,
          "mane_select": "NM_001258392.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.961A>G",
          "hgvs_p": "p.Lys321Glu",
          "transcript": "ENST00000543042.6",
          "protein_id": "ENSP00000439746.2",
          "transcript_support_level": 2,
          "aa_start": 321,
          "aa_end": null,
          "aa_length": 692,
          "cds_start": 961,
          "cds_end": null,
          "cds_length": 2079,
          "cdna_start": 1094,
          "cdna_end": null,
          "cdna_length": 2276,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.826A>G",
          "hgvs_p": "p.Lys276Glu",
          "transcript": "NM_001258394.3",
          "protein_id": "NP_001245323.1",
          "transcript_support_level": null,
          "aa_start": 276,
          "aa_end": null,
          "aa_length": 662,
          "cds_start": 826,
          "cds_end": null,
          "cds_length": 1989,
          "cdna_start": 1125,
          "cdna_end": null,
          "cdna_length": 10160,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.784A>G",
          "hgvs_p": "p.Lys262Glu",
          "transcript": "NM_001258393.3",
          "protein_id": "NP_001245322.1",
          "transcript_support_level": null,
          "aa_start": 262,
          "aa_end": null,
          "aa_length": 648,
          "cds_start": 784,
          "cds_end": null,
          "cds_length": 1947,
          "cdna_start": 841,
          "cdna_end": null,
          "cdna_length": 9876,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.784A>G",
          "hgvs_p": "p.Lys262Glu",
          "transcript": "ENST00000340729.9",
          "protein_id": "ENSP00000340385.5",
          "transcript_support_level": 2,
          "aa_start": 262,
          "aa_end": null,
          "aa_length": 648,
          "cds_start": 784,
          "cds_end": null,
          "cds_length": 1947,
          "cdna_start": 844,
          "cdna_end": null,
          "cdna_length": 2071,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.358A>G",
          "hgvs_p": "p.Lys120Glu",
          "transcript": "ENST00000642288.1",
          "protein_id": "ENSP00000495167.1",
          "transcript_support_level": null,
          "aa_start": 120,
          "aa_end": null,
          "aa_length": 381,
          "cds_start": 358,
          "cds_end": null,
          "cds_length": 1146,
          "cdna_start": 633,
          "cdna_end": null,
          "cdna_length": 1421,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.433A>G",
          "hgvs_p": "p.Lys145Glu",
          "transcript": "ENST00000544683.5",
          "protein_id": "ENSP00000442651.1",
          "transcript_support_level": 5,
          "aa_start": 145,
          "aa_end": null,
          "aa_length": 151,
          "cds_start": 433,
          "cds_end": null,
          "cds_length": 458,
          "cdna_start": 599,
          "cdna_end": null,
          "cdna_length": 624,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.874A>G",
          "hgvs_p": "p.Lys292Glu",
          "transcript": "XM_005274320.2",
          "protein_id": "XP_005274377.1",
          "transcript_support_level": null,
          "aa_start": 292,
          "aa_end": null,
          "aa_length": 678,
          "cds_start": 874,
          "cds_end": null,
          "cds_length": 2037,
          "cdna_start": 931,
          "cdna_end": null,
          "cdna_length": 9966,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.736A>G",
          "hgvs_p": "p.Lys246Glu",
          "transcript": "XM_047427655.1",
          "protein_id": "XP_047283611.1",
          "transcript_support_level": null,
          "aa_start": 246,
          "aa_end": null,
          "aa_length": 632,
          "cds_start": 736,
          "cds_end": null,
          "cds_length": 1899,
          "cdna_start": 1035,
          "cdna_end": null,
          "cdna_length": 10070,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.448A>G",
          "hgvs_p": "p.Lys150Glu",
          "transcript": "XM_047427656.1",
          "protein_id": "XP_047283612.1",
          "transcript_support_level": null,
          "aa_start": 150,
          "aa_end": null,
          "aa_length": 536,
          "cds_start": 448,
          "cds_end": null,
          "cds_length": 1611,
          "cdna_start": 1227,
          "cdna_end": null,
          "cdna_length": 10262,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "K",
          "aa_alt": "E",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "c.961A>G",
          "hgvs_p": "p.Lys321Glu",
          "transcript": "XM_011545289.3",
          "protein_id": "XP_011543591.1",
          "transcript_support_level": null,
          "aa_start": 321,
          "aa_end": null,
          "aa_length": 371,
          "cds_start": 961,
          "cds_end": null,
          "cds_length": 1116,
          "cdna_start": 1018,
          "cdna_end": null,
          "cdna_length": 3661,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "n.*296A>G",
          "hgvs_p": null,
          "transcript": "ENST00000535477.6",
          "protein_id": "ENSP00000440423.2",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2133,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "n.*561A>G",
          "hgvs_p": null,
          "transcript": "ENST00000535990.6",
          "protein_id": "ENSP00000443822.2",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2501,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "n.294A>G",
          "hgvs_p": null,
          "transcript": "ENST00000544382.5",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 982,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "n.271A>G",
          "hgvs_p": null,
          "transcript": "ENST00000642187.1",
          "protein_id": "ENSP00000494594.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1609,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "n.289A>G",
          "hgvs_p": null,
          "transcript": "ENST00000645105.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1522,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CLPB",
          "gene_hgnc_id": 30664,
          "hgvs_c": "n.215A>G",
          "hgvs_p": null,
          "transcript": "ENST00000645650.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 507,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "hgvs_c": "n.942A>G",
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        },
        {
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          "protein_coding": false,
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          "consequences": [
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          ],
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          "gene_symbol": "CLPB",
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          "transcript": "ENST00000535477.6",
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        },
        {
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          "consequences": [
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          "gene_symbol": "CLPB",
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          "transcript": "ENST00000535990.6",
          "protein_id": "ENSP00000443822.2",
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        },
        {
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          "protein_coding": true,
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          "consequences": [
            "downstream_gene_variant"
          ],
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          "exon_count": 6,
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          "gene_symbol": "CLPB",
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          "hgvs_c": "c.*76A>G",
          "hgvs_p": null,
          "transcript": "ENST00000539148.3",
          "protein_id": "ENSP00000445327.1",
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          "cds_start": -4,
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          "cds_length": 447,
          "cdna_start": null,
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        }
      ],
      "gene_symbol": "CLPB",
      "gene_hgnc_id": 30664,
      "dbsnp": "rs786205139",
      "frequency_reference_population": 6.855532e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 6.85553e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.3558349609375,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.05999999865889549,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "dbscSNV1_RF",
      "revel_score": 0.124,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1149,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.05,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 4.423,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": 0.0022175365356601,
      "dbscsnv_ada_prediction": "Benign",
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_by_gene": [
        {
          "score": 1,
          "benign_score": 1,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000538039.6",
          "gene_symbol": "CLPB",
          "hgnc_id": 30664,
          "effects": [
            "missense_variant",
            "splice_region_variant"
          ],
          "inheritance_mode": "AR,AD",
          "hgvs_c": "c.871A>G",
          "hgvs_p": "p.Lys291Glu"
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}