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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-72693326-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=72693326&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 1,
          "criteria": [
            "BP4"
          ],
          "effects": [
            "missense_variant",
            "splice_region_variant"
          ],
          "gene_symbol": "ARAP1",
          "hgnc_id": 16925,
          "hgvs_c": "c.3953G>A",
          "hgvs_p": "p.Arg1318Gln",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -1,
          "transcript": "NM_001040118.3",
          "verdict": "Likely_benign"
        },
        {
          "benign_score": 1,
          "criteria": [
            "BP4"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ENSG00000286555",
          "hgnc_id": null,
          "hgvs_c": "n.441-2100C>T",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -1,
          "transcript": "ENST00000669205.1",
          "verdict": "Likely_benign"
        },
        {
          "benign_score": 1,
          "criteria": [
            "BP4"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ARAP1-AS1",
          "hgnc_id": 39993,
          "hgvs_c": "n.348-442C>T",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -1,
          "transcript": "ENST00000542022.1",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4",
      "acmg_score": -1,
      "allele_count_reference_population": 37,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.4938,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "bayesdelnoaf_score": -0.02,
      "chr": "11",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.2673874497413635,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1450,
          "aa_ref": "R",
          "aa_start": 1318,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5156,
          "cdna_start": 4161,
          "cds_end": null,
          "cds_length": 4353,
          "cds_start": 3953,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 35,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "NM_001040118.3",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3953G>A",
          "hgvs_p": "p.Arg1318Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000393609.8",
          "protein_coding": true,
          "protein_id": "NP_001035207.1",
          "strand": false,
          "transcript": "NM_001040118.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1450,
          "aa_ref": "R",
          "aa_start": 1318,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5156,
          "cdna_start": 4161,
          "cds_end": null,
          "cds_length": 4353,
          "cds_start": 3953,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 35,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000393609.8",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3953G>A",
          "hgvs_p": "p.Arg1318Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001040118.3",
          "protein_coding": true,
          "protein_id": "ENSP00000377233.3",
          "strand": false,
          "transcript": "ENST00000393609.8",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1210,
          "aa_ref": "R",
          "aa_start": 1078,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4778,
          "cdna_start": 3789,
          "cds_end": null,
          "cds_length": 3633,
          "cds_start": 3233,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 30,
          "exon_rank": 24,
          "exon_rank_end": null,
          "feature": "ENST00000393605.7",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3233G>A",
          "hgvs_p": "p.Arg1078Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000377230.3",
          "strand": false,
          "transcript": "ENST00000393605.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1205,
          "aa_ref": "R",
          "aa_start": 1073,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4942,
          "cdna_start": 3953,
          "cds_end": null,
          "cds_length": 3618,
          "cds_start": 3218,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 33,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000334211.12",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3218G>A",
          "hgvs_p": "p.Arg1073Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000335506.8",
          "strand": false,
          "transcript": "ENST00000334211.12",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1194,
          "aa_ref": "R",
          "aa_start": 1073,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4066,
          "cdna_start": 3623,
          "cds_end": null,
          "cds_length": 3585,
          "cds_start": 3218,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 32,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000426523.5",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3218G>A",
          "hgvs_p": "p.Arg1073Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000392264.1",
          "strand": false,
          "transcript": "ENST00000426523.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1133,
          "aa_ref": "R",
          "aa_start": 1012,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3883,
          "cdna_start": 3440,
          "cds_end": null,
          "cds_length": 3402,
          "cds_start": 3035,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 31,
          "exon_rank": 26,
          "exon_rank_end": null,
          "feature": "ENST00000429686.5",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3035G>A",
          "hgvs_p": "p.Arg1012Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000403127.1",
          "strand": false,
          "transcript": "ENST00000429686.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2758,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 20,
          "exon_rank": 15,
          "exon_rank_end": null,
          "feature": "ENST00000495878.5",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "n.1796G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000495878.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1450,
          "aa_ref": "R",
          "aa_start": 1318,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5058,
          "cdna_start": 4068,
          "cds_end": null,
          "cds_length": 4353,
          "cds_start": 3953,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 34,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000852596.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3953G>A",
          "hgvs_p": "p.Arg1318Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000522655.1",
          "strand": false,
          "transcript": "ENST00000852596.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1450,
          "aa_ref": "R",
          "aa_start": 1318,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5149,
          "cdna_start": 4154,
          "cds_end": null,
          "cds_length": 4353,
          "cds_start": 3953,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 35,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000852598.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3953G>A",
          "hgvs_p": "p.Arg1318Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000522657.1",
          "strand": false,
          "transcript": "ENST00000852598.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1444,
          "aa_ref": "R",
          "aa_start": 1312,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5133,
          "cdna_start": 4138,
          "cds_end": null,
          "cds_length": 4335,
          "cds_start": 3935,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 35,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000932332.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3935G>A",
          "hgvs_p": "p.Arg1312Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000602391.1",
          "strand": false,
          "transcript": "ENST00000932332.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1439,
          "aa_ref": "R",
          "aa_start": 1318,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5767,
          "cdna_start": 4805,
          "cds_end": null,
          "cds_length": 4320,
          "cds_start": 3953,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 34,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000359373.9",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3953G>A",
          "hgvs_p": "p.Arg1318Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000352332.5",
          "strand": false,
          "transcript": "ENST00000359373.9",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1412,
          "aa_ref": "R",
          "aa_start": 1280,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4942,
          "cdna_start": 3952,
          "cds_end": null,
          "cds_length": 4239,
          "cds_start": 3839,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 33,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000932333.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3839G>A",
          "hgvs_p": "p.Arg1280Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000602392.1",
          "strand": false,
          "transcript": "ENST00000932333.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1401,
          "aa_ref": "R",
          "aa_start": 1280,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5006,
          "cdna_start": 4046,
          "cds_end": null,
          "cds_length": 4206,
          "cds_start": 3839,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 33,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000932331.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3839G>A",
          "hgvs_p": "p.Arg1280Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000602390.1",
          "strand": false,
          "transcript": "ENST00000932331.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1389,
          "aa_ref": "R",
          "aa_start": 1257,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5016,
          "cdna_start": 4023,
          "cds_end": null,
          "cds_length": 4170,
          "cds_start": 3770,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 34,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000852595.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3770G>A",
          "hgvs_p": "p.Arg1257Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000522654.1",
          "strand": false,
          "transcript": "ENST00000852595.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1389,
          "aa_ref": "R",
          "aa_start": 1257,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6790,
          "cdna_start": 3930,
          "cds_end": null,
          "cds_length": 4170,
          "cds_start": 3770,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 33,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000932329.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3770G>A",
          "hgvs_p": "p.Arg1257Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000602388.1",
          "strand": false,
          "transcript": "ENST00000932329.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1389,
          "aa_ref": "R",
          "aa_start": 1257,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4944,
          "cdna_start": 3954,
          "cds_end": null,
          "cds_length": 4170,
          "cds_start": 3770,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 34,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000952695.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3770G>A",
          "hgvs_p": "p.Arg1257Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000622754.1",
          "strand": false,
          "transcript": "ENST00000952695.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1358,
          "aa_ref": "R",
          "aa_start": 1237,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4851,
          "cdna_start": 3889,
          "cds_end": null,
          "cds_length": 4077,
          "cds_start": 3710,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_count": 32,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000852597.1",
          "gene_hgnc_id": 16925,
          "gene_symbol": "ARAP1",
          "hgvs_c": "c.3710G>A",
          "hgvs_p": "p.Arg1237Gln",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000522656.1",
          "strand": false,
          "transcript": "ENST00000852597.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "Q",
          "aa_end": null,
          "aa_length": 1205,
          "aa_ref": "R",
          "aa_start": 1073,
          "biotype": "protein_coding",
          "canonical": false,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.