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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-75277415-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=75277415&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 75277415,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_004041.5",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "NM_004041.5",
          "protein_id": "NP_004032.2",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 418,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1257,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000420843.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_004041.5"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000420843.7",
          "protein_id": "ENSP00000409581.2",
          "transcript_support_level": 1,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 418,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1257,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_004041.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000420843.7"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000360025.7",
          "protein_id": "ENSP00000353124.3",
          "transcript_support_level": 1,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 410,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1233,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000360025.7"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000952726.1",
          "protein_id": "ENSP00000622785.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 476,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1431,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952726.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000952725.1",
          "protein_id": "ENSP00000622784.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 446,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1341,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952725.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.733G>A",
          "hgvs_p": "p.Val245Ile",
          "transcript": "ENST00000862393.1",
          "protein_id": "ENSP00000532452.1",
          "transcript_support_level": null,
          "aa_start": 245,
          "aa_end": null,
          "aa_length": 445,
          "cds_start": 733,
          "cds_end": null,
          "cds_length": 1338,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000862393.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000862394.1",
          "protein_id": "ENSP00000532453.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 442,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1329,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000862394.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.733G>A",
          "hgvs_p": "p.Val245Ile",
          "transcript": "ENST00000928507.1",
          "protein_id": "ENSP00000598566.1",
          "transcript_support_level": null,
          "aa_start": 245,
          "aa_end": null,
          "aa_length": 437,
          "cds_start": 733,
          "cds_end": null,
          "cds_length": 1314,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928507.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000862395.1",
          "protein_id": "ENSP00000532454.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 434,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1305,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000862395.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "NM_020251.4",
          "protein_id": "NP_064647.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 410,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1233,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_020251.4"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.616G>A",
          "hgvs_p": "p.Val206Ile",
          "transcript": "ENST00000862396.1",
          "protein_id": "ENSP00000532455.1",
          "transcript_support_level": null,
          "aa_start": 206,
          "aa_end": null,
          "aa_length": 406,
          "cds_start": 616,
          "cds_end": null,
          "cds_length": 1221,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000862396.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.631G>A",
          "hgvs_p": "p.Val211Ile",
          "transcript": "ENST00000952724.1",
          "protein_id": "ENSP00000622783.1",
          "transcript_support_level": null,
          "aa_start": 211,
          "aa_end": null,
          "aa_length": 403,
          "cds_start": 631,
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          "cds_length": 1212,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000952724.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.616G>A",
          "hgvs_p": "p.Val206Ile",
          "transcript": "ENST00000862397.1",
          "protein_id": "ENSP00000532456.1",
          "transcript_support_level": null,
          "aa_start": 206,
          "aa_end": null,
          "aa_length": 398,
          "cds_start": 616,
          "cds_end": null,
          "cds_length": 1197,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000862397.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000952727.1",
          "protein_id": "ENSP00000622786.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 398,
          "cds_start": 652,
          "cds_end": null,
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          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000952727.1"
        },
        {
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          "protein_coding": true,
          "strand": false,
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          ],
          "exon_rank": 9,
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          "exon_count": 14,
          "intron_rank": null,
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          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "ENST00000862392.1",
          "protein_id": "ENSP00000532451.1",
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          "aa_end": null,
          "aa_length": 382,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1149,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000862392.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.637G>A",
          "hgvs_p": "p.Val213Ile",
          "transcript": "ENST00000532525.1",
          "protein_id": "ENSP00000433171.1",
          "transcript_support_level": 5,
          "aa_start": 213,
          "aa_end": null,
          "aa_length": 256,
          "cds_start": 637,
          "cds_end": null,
          "cds_length": 773,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000532525.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.124G>A",
          "hgvs_p": "p.Val42Ile",
          "transcript": "ENST00000532447.5",
          "protein_id": "ENSP00000436530.1",
          "transcript_support_level": 5,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 194,
          "cds_start": 124,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "V",
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          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.745G>A",
          "hgvs_p": "p.Val249Ile",
          "transcript": "XM_017017750.1",
          "protein_id": "XP_016873239.1",
          "transcript_support_level": null,
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          "aa_end": null,
          "aa_length": 473,
          "cds_start": 745,
          "cds_end": null,
          "cds_length": 1422,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017017750.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
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          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.745G>A",
          "hgvs_p": "p.Val249Ile",
          "transcript": "XM_017017751.1",
          "protein_id": "XP_016873240.1",
          "transcript_support_level": null,
          "aa_start": 249,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": 745,
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          "cds_length": 1398,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017017751.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.745G>A",
          "hgvs_p": "p.Val249Ile",
          "transcript": "XM_011545034.2",
          "protein_id": "XP_011543336.1",
          "transcript_support_level": null,
          "aa_start": 249,
          "aa_end": null,
          "aa_length": 449,
          "cds_start": 745,
          "cds_end": null,
          "cds_length": 1350,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011545034.2"
        },
        {
          "aa_ref": "V",
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          "intron_rank": null,
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          "hgvs_p": "p.Val218Ile",
          "transcript": "XM_017017752.3",
          "protein_id": "XP_016873241.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 442,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1329,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017017752.3"
        },
        {
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          "protein_coding": true,
          "strand": false,
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          ],
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          "exon_count": 16,
          "intron_rank": null,
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          "gene_symbol": "ARRB1",
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          "hgvs_c": "c.745G>A",
          "hgvs_p": "p.Val249Ile",
          "transcript": "XM_011545035.2",
          "protein_id": "XP_011543337.1",
          "transcript_support_level": null,
          "aa_start": 249,
          "aa_end": null,
          "aa_length": 441,
          "cds_start": 745,
          "cds_end": null,
          "cds_length": 1326,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011545035.2"
        },
        {
          "aa_ref": "V",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.637G>A",
          "hgvs_p": "p.Val213Ile",
          "transcript": "XM_017017753.1",
          "protein_id": "XP_016873242.1",
          "transcript_support_level": null,
          "aa_start": 213,
          "aa_end": null,
          "aa_length": 437,
          "cds_start": 637,
          "cds_end": null,
          "cds_length": 1314,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017017753.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ARRB1",
          "gene_hgnc_id": 711,
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile",
          "transcript": "XM_017017754.3",
          "protein_id": "XP_016873243.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 434,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 1305,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017017754.3"
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      ],
      "gene_symbol": "ARRB1",
      "gene_hgnc_id": 711,
      "dbsnp": "rs770803825",
      "frequency_reference_population": 0.000027260112,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 44,
      "gnomad_exomes_af": 0.0000287304,
      "gnomad_genomes_af": 0.0000131392,
      "gnomad_exomes_ac": 42,
      "gnomad_genomes_ac": 2,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.31910112500190735,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.412,
      "revel_prediction": "Uncertain_significance",
      "alphamissense_score": 0.1366,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.36,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 7.593,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -5,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4,BS2",
      "acmg_by_gene": [
        {
          "score": -5,
          "benign_score": 5,
          "pathogenic_score": 0,
          "criteria": [
            "BP4",
            "BS2"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_004041.5",
          "gene_symbol": "ARRB1",
          "hgnc_id": 711,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.652G>A",
          "hgvs_p": "p.Val218Ile"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}