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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-7565595-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=7565595&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 7565595,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_001351853.2",
      "consequences": [
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "NM_003621.5",
          "protein_id": "NP_003612.3",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 876,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2631,
          "cdna_start": 266,
          "cdna_end": null,
          "cdna_length": 3328,
          "mane_select": "ENST00000299492.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_003621.5"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000299492.9",
          "protein_id": "ENSP00000299492.4",
          "transcript_support_level": 1,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 876,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2631,
          "cdna_start": 266,
          "cdna_end": null,
          "cdna_length": 3328,
          "mane_select": "NM_003621.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000299492.9"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "NM_001351853.2",
          "protein_id": "NP_001338782.2",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 928,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2787,
          "cdna_start": 266,
          "cdna_end": null,
          "cdna_length": 3060,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351853.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000684123.1",
          "protein_id": "ENSP00000507842.1",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": 317,
          "cdna_end": null,
          "cdna_length": 3274,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000684123.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "NM_001351854.2",
          "protein_id": "NP_001338783.2",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 917,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2754,
          "cdna_start": 266,
          "cdna_end": null,
          "cdna_length": 3027,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351854.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "NM_001351855.2",
          "protein_id": "NP_001338784.2",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 887,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2664,
          "cdna_start": 266,
          "cdna_end": null,
          "cdna_length": 3361,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351855.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "NM_001351856.2",
          "protein_id": "NP_001338785.2",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 878,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2637,
          "cdna_start": 266,
          "cdna_end": null,
          "cdna_length": 3334,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351856.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "NM_001351862.2",
          "protein_id": "NP_001338791.2",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 876,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2631,
          "cdna_start": 422,
          "cdna_end": null,
          "cdna_length": 3484,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001351862.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000857461.1",
          "protein_id": "ENSP00000527520.1",
          "transcript_support_level": null,
          "aa_start": 36,
          "aa_end": null,
          "aa_length": 876,
          "cds_start": 107,
          "cds_end": null,
          "cds_length": 2631,
          "cdna_start": 247,
          "cdna_end": null,
          "cdna_length": 3311,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000857461.1"
        },
        {
          "aa_ref": "P",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
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          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000857462.1",
          "protein_id": "ENSP00000527521.1",
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          "aa_start": 36,
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          "cdna_start": 587,
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          "mane_select": null,
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        {
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          "strand": true,
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          ],
          "exon_rank": 3,
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          "exon_count": 24,
          "intron_rank": null,
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          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000857460.1",
          "protein_id": "ENSP00000527519.1",
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          "cds_start": 107,
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          "cdna_start": 291,
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        {
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          "hgvs_p": "p.Pro36Leu",
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        {
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          ],
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          "gene_symbol": "PPFIBP2",
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          "biotype": "protein_coding",
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        {
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          "strand": true,
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          ],
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          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "PPFIBP2",
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          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
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          "protein_id": "ENSP00000434641.1",
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        {
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          "gene_symbol": "PPFIBP2",
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          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000528947.5",
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          "biotype": "protein_coding",
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        {
          "aa_ref": "P",
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          "exon_rank": 3,
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          "exon_count": 3,
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          "gene_symbol": "PPFIBP2",
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          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "ENST00000526046.1",
          "protein_id": "ENSP00000433026.1",
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        {
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          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
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          "transcript": "XM_006718349.4",
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        {
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          "biotype": "protein_coding",
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        },
        {
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          "strand": true,
          "consequences": [
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          ],
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          "exon_count": 26,
          "intron_rank": null,
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          "gene_symbol": "PPFIBP2",
          "gene_hgnc_id": 9250,
          "hgvs_c": "c.107C>T",
          "hgvs_p": "p.Pro36Leu",
          "transcript": "XM_005253177.4",
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      "splice_prediction_selected": "Benign",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
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      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.