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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-7628409-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=7628409&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 7628409,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000299492.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "NM_003621.5",
"protein_id": "NP_003612.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 876,
"cds_start": -4,
"cds_end": null,
"cds_length": 2631,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3328,
"mane_select": "ENST00000299492.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "ENST00000299492.9",
"protein_id": "ENSP00000299492.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 876,
"cds_start": -4,
"cds_end": null,
"cds_length": 2631,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3328,
"mane_select": "NM_003621.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.414+63C>T",
"hgvs_p": null,
"transcript": "ENST00000533792.5",
"protein_id": "ENSP00000436498.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 718,
"cds_start": -4,
"cds_end": null,
"cds_length": 2157,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3003,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "NM_001351853.2",
"protein_id": "NP_001338782.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 928,
"cds_start": -4,
"cds_end": null,
"cds_length": 2787,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3060,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "ENST00000684123.1",
"protein_id": "ENSP00000507842.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 927,
"cds_start": -4,
"cds_end": null,
"cds_length": 2784,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3274,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "NM_001351854.2",
"protein_id": "NP_001338783.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 917,
"cds_start": -4,
"cds_end": null,
"cds_length": 2754,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3027,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "NM_001351855.2",
"protein_id": "NP_001338784.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 887,
"cds_start": -4,
"cds_end": null,
"cds_length": 2664,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3361,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.894+63C>T",
"hgvs_p": null,
"transcript": "NM_001351856.2",
"protein_id": "NP_001338785.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 878,
"cds_start": -4,
"cds_end": null,
"cds_length": 2637,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.888+63C>T",
"hgvs_p": null,
"transcript": "NM_001351862.2",
"protein_id": "NP_001338791.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 876,
"cds_start": -4,
"cds_end": null,
"cds_length": 2631,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3484,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.657+63C>T",
"hgvs_p": null,
"transcript": "NM_001351857.2",
"protein_id": "NP_001338786.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 850,
"cds_start": -4,
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"cds_length": 2553,
"cdna_start": null,
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"cdna_length": 4447,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.657+63C>T",
"hgvs_p": null,
"transcript": "NM_001351858.2",
"protein_id": "NP_001338787.2",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "PPFIBP2",
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"hgvs_c": "c.657+63C>T",
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"transcript": "NM_001351859.2",
"protein_id": "NP_001338788.2",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 7,
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"gene_symbol": "PPFIBP2",
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"hgvs_c": "c.657+63C>T",
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"transcript": "ENST00000684215.1",
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},
{
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"strand": true,
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],
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"intron_rank": 7,
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"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.681+63C>T",
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},
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],
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"gene_symbol": "PPFIBP2",
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"transcript": "NM_001351861.2",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "PPFIBP2",
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"hgvs_c": "c.552+63C>T",
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},
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],
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"gene_symbol": "PPFIBP2",
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"hgvs_c": "c.552+63C>T",
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"transcript": "ENST00000528883.5",
"protein_id": "ENSP00000435469.1",
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},
{
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"strand": true,
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],
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"intron_rank": 5,
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"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "c.459+63C>T",
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"transcript": "NM_001256569.2",
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},
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],
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"gene_symbol": "PPFIBP2",
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"transcript": "ENST00000530181.5",
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],
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},
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],
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"gene_symbol": "PPFIBP2",
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "n.143+63C>T",
"hgvs_p": null,
"transcript": "ENST00000532416.1",
"protein_id": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PPFIBP2",
"gene_hgnc_id": 9250,
"hgvs_c": "n.1097+17987C>T",
"hgvs_p": null,
"transcript": "ENST00000532926.5",
"protein_id": null,
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