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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-828684-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=828684&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 828684,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001286606.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "NM_001286606.2",
"protein_id": "NP_001273535.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 399,
"cds_start": 77,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000525077.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286606.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000525077.2",
"protein_id": "ENSP00000435299.1",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 399,
"cds_start": 77,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001286606.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525077.2"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000450448.5",
"protein_id": "ENSP00000409256.1",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 294,
"cds_start": 77,
"cds_end": null,
"cds_length": 885,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000450448.5"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000528542.6",
"protein_id": "ENSP00000432334.1",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 294,
"cds_start": 77,
"cds_end": null,
"cds_length": 885,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000528542.6"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000948433.1",
"protein_id": "ENSP00000618492.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 421,
"cds_start": 77,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948433.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000948431.1",
"protein_id": "ENSP00000618490.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 405,
"cds_start": 77,
"cds_end": null,
"cds_length": 1218,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948431.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000948432.1",
"protein_id": "ENSP00000618491.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 405,
"cds_start": 77,
"cds_end": null,
"cds_length": 1218,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948432.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000948434.1",
"protein_id": "ENSP00000618493.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 405,
"cds_start": 77,
"cds_end": null,
"cds_length": 1218,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948434.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000865120.1",
"protein_id": "ENSP00000535179.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 399,
"cds_start": 77,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865120.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000865121.1",
"protein_id": "ENSP00000535180.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 399,
"cds_start": 77,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865121.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000865122.1",
"protein_id": "ENSP00000535181.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 399,
"cds_start": 77,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865122.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000948430.1",
"protein_id": "ENSP00000618489.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 399,
"cds_start": 77,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948430.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "NM_173584.4",
"protein_id": "NP_775855.3",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 294,
"cds_start": 77,
"cds_end": null,
"cds_length": 885,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173584.4"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000527089.5",
"protein_id": "ENSP00000432726.1",
"transcript_support_level": 3,
"aa_start": 26,
"aa_end": null,
"aa_length": 87,
"cds_start": 77,
"cds_end": null,
"cds_length": 264,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000527089.5"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000533803.1",
"protein_id": "ENSP00000433602.1",
"transcript_support_level": 2,
"aa_start": 26,
"aa_end": null,
"aa_length": 80,
"cds_start": 77,
"cds_end": null,
"cds_length": 243,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000533803.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000530183.1",
"protein_id": "ENSP00000436624.1",
"transcript_support_level": 5,
"aa_start": 26,
"aa_end": null,
"aa_length": 52,
"cds_start": 77,
"cds_end": null,
"cds_length": 159,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000530183.1"
},
{
"aa_ref": "P",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.77C>T",
"hgvs_p": "p.Pro26Leu",
"transcript": "ENST00000528315.1",
"protein_id": "ENSP00000434198.1",
"transcript_support_level": 3,
"aa_start": 26,
"aa_end": null,
"aa_length": 33,
"cds_start": 77,
"cds_end": null,
"cds_length": 104,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000528315.1"
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.49C>T",
"hgvs_p": "p.Arg17Cys",
"transcript": "XM_017017582.2",
"protein_id": "XP_016873071.1",
"transcript_support_level": null,
"aa_start": 17,
"aa_end": null,
"aa_length": 627,
"cds_start": 49,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017582.2"
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.49C>T",
"hgvs_p": "p.Arg17Cys",
"transcript": "XM_017017583.2",
"protein_id": "XP_016873072.1",
"transcript_support_level": null,
"aa_start": 17,
"aa_end": null,
"aa_length": 627,
"cds_start": 49,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017583.2"
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.49C>T",
"hgvs_p": "p.Arg17Cys",
"transcript": "XM_017017584.2",
"protein_id": "XP_016873073.1",
"transcript_support_level": null,
"aa_start": 17,
"aa_end": null,
"aa_length": 627,
"cds_start": 49,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017584.2"
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.49C>T",
"hgvs_p": "p.Arg17Cys",
"transcript": "XM_017017585.2",
"protein_id": "XP_016873074.1",
"transcript_support_level": null,
"aa_start": 17,
"aa_end": null,
"aa_length": 627,
"cds_start": 49,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017585.2"
},
{
"aa_ref": "R",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.49C>T",
"hgvs_p": "p.Arg17Cys",
"transcript": "XM_017017586.2",
"protein_id": "XP_016873075.1",
"transcript_support_level": null,
"aa_start": 17,
"aa_end": null,
"aa_length": 627,
"cds_start": 49,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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{
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],
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"clinvar_classification": "Uncertain significance",
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"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
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}
],
"message": null
}