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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-828952-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=828952&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 828952,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001286606.2",
"consequences": [
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "NM_001286606.2",
"protein_id": "NP_001273535.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 399,
"cds_start": 266,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 955,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": "ENST00000525077.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286606.2"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000525077.2",
"protein_id": "ENSP00000435299.1",
"transcript_support_level": 1,
"aa_start": 89,
"aa_end": null,
"aa_length": 399,
"cds_start": 266,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 955,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": "NM_001286606.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525077.2"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000450448.5",
"protein_id": "ENSP00000409256.1",
"transcript_support_level": 1,
"aa_start": 89,
"aa_end": null,
"aa_length": 294,
"cds_start": 266,
"cds_end": null,
"cds_length": 885,
"cdna_start": 614,
"cdna_end": null,
"cdna_length": 1663,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000450448.5"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000528542.6",
"protein_id": "ENSP00000432334.1",
"transcript_support_level": 1,
"aa_start": 89,
"aa_end": null,
"aa_length": 294,
"cds_start": 266,
"cds_end": null,
"cds_length": 885,
"cdna_start": 748,
"cdna_end": null,
"cdna_length": 1792,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000528542.6"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000948433.1",
"protein_id": "ENSP00000618492.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 421,
"cds_start": 266,
"cds_end": null,
"cds_length": 1266,
"cdna_start": 1571,
"cdna_end": null,
"cdna_length": 2837,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948433.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000948431.1",
"protein_id": "ENSP00000618490.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 405,
"cds_start": 266,
"cds_end": null,
"cds_length": 1218,
"cdna_start": 833,
"cdna_end": null,
"cdna_length": 2062,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948431.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000948432.1",
"protein_id": "ENSP00000618491.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 405,
"cds_start": 266,
"cds_end": null,
"cds_length": 1218,
"cdna_start": 1054,
"cdna_end": null,
"cdna_length": 2282,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948432.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000948434.1",
"protein_id": "ENSP00000618493.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 405,
"cds_start": 266,
"cds_end": null,
"cds_length": 1218,
"cdna_start": 1313,
"cdna_end": null,
"cdna_length": 2540,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948434.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000865120.1",
"protein_id": "ENSP00000535179.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 399,
"cds_start": 266,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 412,
"cdna_end": null,
"cdna_length": 1623,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865120.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000865121.1",
"protein_id": "ENSP00000535180.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 399,
"cds_start": 266,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 1188,
"cdna_end": null,
"cdna_length": 2406,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865121.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000865122.1",
"protein_id": "ENSP00000535181.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 399,
"cds_start": 266,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 787,
"cdna_end": null,
"cdna_length": 2004,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865122.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "ENST00000948430.1",
"protein_id": "ENSP00000618489.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 399,
"cds_start": 266,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 826,
"cdna_end": null,
"cdna_length": 2040,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948430.1"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "NM_173584.4",
"protein_id": "NP_775855.3",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 294,
"cds_start": 266,
"cds_end": null,
"cds_length": 885,
"cdna_start": 614,
"cdna_end": null,
"cdna_length": 1663,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173584.4"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017582.2",
"protein_id": "XP_016873071.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 754,
"cdna_end": null,
"cdna_length": 2682,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017582.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017583.2",
"protein_id": "XP_016873072.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 724,
"cdna_end": null,
"cdna_length": 2652,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017583.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017584.2",
"protein_id": "XP_016873073.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 808,
"cdna_end": null,
"cdna_length": 2736,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017584.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017585.2",
"protein_id": "XP_016873074.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 778,
"cdna_end": null,
"cdna_length": 2706,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017585.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017586.2",
"protein_id": "XP_016873075.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1175,
"cdna_end": null,
"cdna_length": 3103,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017586.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017587.2",
"protein_id": "XP_016873076.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 409,
"cdna_end": null,
"cdna_length": 2337,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017587.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017588.2",
"protein_id": "XP_016873077.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 627,
"cds_start": 238,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 463,
"cdna_end": null,
"cdna_length": 2391,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017588.2"
},
{
"aa_ref": "A",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.238G>C",
"hgvs_p": "p.Ala80Pro",
"transcript": "XM_017017589.2",
"protein_id": "XP_016873078.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 621,
"cds_start": 238,
"cds_end": null,
"cds_length": 1866,
"cdna_start": 955,
"cdna_end": null,
"cdna_length": 2865,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017017589.2"
},
{
"aa_ref": "C",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.266G>C",
"hgvs_p": "p.Cys89Ser",
"transcript": "XM_017017590.2",
"protein_id": "XP_016873079.1",
"transcript_support_level": null,
"aa_start": 89,
"aa_end": null,
"aa_length": 563,
"cds_start": 266,
"cds_end": null,
"cds_length": 1692,
"cdna_start": 754,
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{
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}
],
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"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}