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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-830670-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=830670&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 830670,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000525077.2",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.743G>T",
"hgvs_p": "p.Ser248Ile",
"transcript": "NM_001286606.2",
"protein_id": "NP_001273535.1",
"transcript_support_level": null,
"aa_start": 248,
"aa_end": null,
"aa_length": 399,
"cds_start": 743,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 1432,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": "ENST00000525077.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.743G>T",
"hgvs_p": "p.Ser248Ile",
"transcript": "ENST00000525077.2",
"protein_id": "ENSP00000435299.1",
"transcript_support_level": 1,
"aa_start": 248,
"aa_end": null,
"aa_length": 399,
"cds_start": 743,
"cds_end": null,
"cds_length": 1200,
"cdna_start": 1432,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": "NM_001286606.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.743G>T",
"hgvs_p": "p.Ser248Ile",
"transcript": "ENST00000450448.5",
"protein_id": "ENSP00000409256.1",
"transcript_support_level": 1,
"aa_start": 248,
"aa_end": null,
"aa_length": 294,
"cds_start": 743,
"cds_end": null,
"cds_length": 885,
"cdna_start": 1091,
"cdna_end": null,
"cdna_length": 1663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.743G>T",
"hgvs_p": "p.Ser248Ile",
"transcript": "ENST00000528542.6",
"protein_id": "ENSP00000432334.1",
"transcript_support_level": 1,
"aa_start": 248,
"aa_end": null,
"aa_length": 294,
"cds_start": 743,
"cds_end": null,
"cds_length": 885,
"cdna_start": 1225,
"cdna_end": null,
"cdna_length": 1792,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.743G>T",
"hgvs_p": "p.Ser248Ile",
"transcript": "NM_173584.4",
"protein_id": "NP_775855.3",
"transcript_support_level": null,
"aa_start": 248,
"aa_end": null,
"aa_length": 294,
"cds_start": 743,
"cds_end": null,
"cds_length": 885,
"cdna_start": 1091,
"cdna_end": null,
"cdna_length": 1663,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017582.2",
"protein_id": "XP_016873071.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1752,
"cdna_end": null,
"cdna_length": 2682,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017583.2",
"protein_id": "XP_016873072.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1722,
"cdna_end": null,
"cdna_length": 2652,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017584.2",
"protein_id": "XP_016873073.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1806,
"cdna_end": null,
"cdna_length": 2736,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017585.2",
"protein_id": "XP_016873074.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1776,
"cdna_end": null,
"cdna_length": 2706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017586.2",
"protein_id": "XP_016873075.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 2173,
"cdna_end": null,
"cdna_length": 3103,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017587.2",
"protein_id": "XP_016873076.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1407,
"cdna_end": null,
"cdna_length": 2337,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017588.2",
"protein_id": "XP_016873077.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 627,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1461,
"cdna_end": null,
"cdna_length": 2391,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1218G>T",
"hgvs_p": "p.Glu406Asp",
"transcript": "XM_017017589.2",
"protein_id": "XP_016873078.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 621,
"cds_start": 1218,
"cds_end": null,
"cds_length": 1866,
"cdna_start": 1935,
"cdna_end": null,
"cdna_length": 2865,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1044G>T",
"hgvs_p": "p.Glu348Asp",
"transcript": "XM_017017590.2",
"protein_id": "XP_016873079.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 563,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1692,
"cdna_start": 1532,
"cdna_end": null,
"cdna_length": 2462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1044G>T",
"hgvs_p": "p.Glu348Asp",
"transcript": "XM_017017591.2",
"protein_id": "XP_016873080.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 563,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1692,
"cdna_start": 1502,
"cdna_end": null,
"cdna_length": 2432,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1044G>T",
"hgvs_p": "p.Glu348Asp",
"transcript": "XM_017017592.2",
"protein_id": "XP_016873081.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 563,
"cds_start": 1044,
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"cdna_start": 1556,
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"cdna_length": 2486,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1044G>T",
"hgvs_p": "p.Glu348Asp",
"transcript": "XM_017017593.2",
"protein_id": "XP_016873082.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 563,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1692,
"cdna_start": 1953,
"cdna_end": null,
"cdna_length": 2883,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1044G>T",
"hgvs_p": "p.Glu348Asp",
"transcript": "XM_017017594.2",
"protein_id": "XP_016873083.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 563,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1692,
"cdna_start": 1187,
"cdna_end": null,
"cdna_length": 2117,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1044G>T",
"hgvs_p": "p.Glu348Asp",
"transcript": "XM_017017595.2",
"protein_id": "XP_016873084.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 563,
"cds_start": 1044,
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"cdna_start": 1241,
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"cdna_length": 2171,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1026G>T",
"hgvs_p": "p.Glu342Asp",
"transcript": "XM_047426804.1",
"protein_id": "XP_047282760.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 557,
"cds_start": 1026,
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"cdna_start": 1568,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1026G>T",
"hgvs_p": "p.Glu342Asp",
"transcript": "XM_047426805.1",
"protein_id": "XP_047282761.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 557,
"cds_start": 1026,
"cds_end": null,
"cds_length": 1674,
"cdna_start": 1538,
"cdna_end": null,
"cdna_length": 2468,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CRACR2B",
"gene_hgnc_id": 28703,
"hgvs_c": "c.1236G>T",
"hgvs_p": "p.Glu412Asp",
"transcript": "XM_017017597.2",
"protein_id": "XP_016873086.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 514,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1545,
"cdna_start": 1953,
"cdna_end": null,
"cdna_length": 2692,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
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}
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}