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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-85663949-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=85663949&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 85663949,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000527447.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "NM_001039618.4",
"protein_id": "NP_001034707.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
"cds_end": null,
"cds_length": 1065,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 7140,
"mane_select": "ENST00000527447.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "ENST00000527447.2",
"protein_id": "ENSP00000433459.1",
"transcript_support_level": 6,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
"cds_end": null,
"cds_length": 1065,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 7140,
"mane_select": "NM_001039618.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.927G>A",
"hgvs_p": null,
"transcript": "ENST00000490820.2",
"protein_id": "ENSP00000434281.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4329,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "ENST00000850607.1",
"protein_id": "ENSP00000520895.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
"cds_end": null,
"cds_length": 1065,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 7304,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_006718642.4",
"protein_id": "XP_006718705.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 358,
"cds_start": 927,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 4972,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_017018086.2",
"protein_id": "XP_016873575.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 358,
"cds_start": 927,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 5976,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_047427375.1",
"protein_id": "XP_047283331.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 358,
"cds_start": 927,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 5136,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_047427376.1",
"protein_id": "XP_047283332.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 358,
"cds_start": 927,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 6206,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_047427377.1",
"protein_id": "XP_047283333.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 358,
"cds_start": 927,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 4906,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_047427378.1",
"protein_id": "XP_047283334.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 358,
"cds_start": 927,
"cds_end": null,
"cds_length": 1077,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 4415,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_011545195.3",
"protein_id": "XP_011543497.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
"cds_end": null,
"cds_length": 1065,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 5185,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_017018088.2",
"protein_id": "XP_016873577.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
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"cds_length": 1065,
"cdna_start": 1181,
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"cdna_length": 6419,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_017018089.2",
"protein_id": "XP_016873578.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
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"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 5349,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_017018090.2",
"protein_id": "XP_016873579.1",
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"mane_select": null,
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"feature": null
},
{
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"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "c.927G>A",
"hgvs_p": "p.Pro309Pro",
"transcript": "XM_047427379.1",
"protein_id": "XP_047283335.1",
"transcript_support_level": null,
"aa_start": 309,
"aa_end": null,
"aa_length": 354,
"cds_start": 927,
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"cdna_start": 1181,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.705G>A",
"hgvs_p": null,
"transcript": "ENST00000260058.9",
"protein_id": "ENSP00000260058.5",
"transcript_support_level": 2,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.927G>A",
"hgvs_p": null,
"transcript": "ENST00000525639.1",
"protein_id": "ENSP00000435762.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.240G>A",
"hgvs_p": null,
"transcript": "ENST00000527529.6",
"protein_id": "ENSP00000433380.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_length": 898,
"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.156G>A",
"hgvs_p": null,
"transcript": "ENST00000528561.5",
"protein_id": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.927G>A",
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"transcript": "ENST00000682836.1",
"protein_id": "ENSP00000507358.1",
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.1181G>A",
"hgvs_p": null,
"transcript": "NR_028024.3",
"protein_id": null,
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"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.1181G>A",
"hgvs_p": null,
"transcript": "NR_028025.3",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 5861,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CREBZF",
"gene_hgnc_id": 24905,
"hgvs_c": "n.1181G>A",
"hgvs_p": null,
"transcript": "NR_028026.3",
"protein_id": null,
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