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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-85725457-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=85725457&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 85725457,
"ref": "T",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000359152.10",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "NM_206927.4",
"protein_id": "NP_996810.2",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2239,
"cds_start": 3901,
"cds_end": null,
"cds_length": 6720,
"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 8263,
"mane_select": "ENST00000359152.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "ENST00000359152.10",
"protein_id": "ENSP00000352065.7",
"transcript_support_level": 1,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2239,
"cds_start": 3901,
"cds_end": null,
"cds_length": 6720,
"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 8263,
"mane_select": "NM_206927.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "n.2572A>C",
"hgvs_p": null,
"transcript": "ENST00000525423.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6250,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.1459+2439A>C",
"hgvs_p": null,
"transcript": "ENST00000528231.5",
"protein_id": "ENSP00000431701.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 934,
"cds_start": -4,
"cds_end": null,
"cds_length": 2805,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3536,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.1459+2439A>C",
"hgvs_p": null,
"transcript": "ENST00000389960.8",
"protein_id": "ENSP00000374610.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": -4,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3898A>C",
"hgvs_p": "p.Met1300Leu",
"transcript": "NM_001394447.1",
"protein_id": "NP_001381376.1",
"transcript_support_level": null,
"aa_start": 1300,
"aa_end": null,
"aa_length": 2238,
"cds_start": 3898,
"cds_end": null,
"cds_length": 6717,
"cdna_start": 4475,
"cdna_end": null,
"cdna_length": 8260,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "NM_001394448.1",
"protein_id": "NP_001381377.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2223,
"cds_start": 3901,
"cds_end": null,
"cds_length": 6672,
"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 8215,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "NM_001394449.1",
"protein_id": "NP_001381378.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2223,
"cds_start": 3901,
"cds_end": null,
"cds_length": 6672,
"cdna_start": 4578,
"cdna_end": null,
"cdna_length": 8315,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "ENST00000634661.1",
"protein_id": "ENSP00000489269.1",
"transcript_support_level": 5,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2223,
"cds_start": 3901,
"cds_end": null,
"cds_length": 6672,
"cdna_start": 3901,
"cdna_end": null,
"cdna_length": 6672,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3898A>C",
"hgvs_p": "p.Met1300Leu",
"transcript": "NM_206928.4",
"protein_id": "NP_996811.2",
"transcript_support_level": null,
"aa_start": 1300,
"aa_end": null,
"aa_length": 2222,
"cds_start": 3898,
"cds_end": null,
"cds_length": 6669,
"cdna_start": 4475,
"cdna_end": null,
"cdna_length": 8212,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3820A>C",
"hgvs_p": "p.Met1274Leu",
"transcript": "NM_001394473.1",
"protein_id": "NP_001381402.1",
"transcript_support_level": null,
"aa_start": 1274,
"aa_end": null,
"aa_length": 2212,
"cds_start": 3820,
"cds_end": null,
"cds_length": 6639,
"cdna_start": 4397,
"cdna_end": null,
"cdna_length": 8182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3820A>C",
"hgvs_p": "p.Met1274Leu",
"transcript": "NM_001394450.1",
"protein_id": "NP_001381379.1",
"transcript_support_level": null,
"aa_start": 1274,
"aa_end": null,
"aa_length": 2196,
"cds_start": 3820,
"cds_end": null,
"cds_length": 6591,
"cdna_start": 4397,
"cdna_end": null,
"cdna_length": 8134,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3817A>C",
"hgvs_p": "p.Met1273Leu",
"transcript": "NM_001394451.1",
"protein_id": "NP_001381380.1",
"transcript_support_level": null,
"aa_start": 1273,
"aa_end": null,
"aa_length": 2195,
"cds_start": 3817,
"cds_end": null,
"cds_length": 6588,
"cdna_start": 4394,
"cdna_end": null,
"cdna_length": 8131,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "NM_001394452.1",
"protein_id": "NP_001381381.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2035,
"cds_start": 3901,
"cds_end": null,
"cds_length": 6108,
"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 7651,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3817A>C",
"hgvs_p": "p.Met1273Leu",
"transcript": "XM_017017934.2",
"protein_id": "XP_016873423.1",
"transcript_support_level": null,
"aa_start": 1273,
"aa_end": null,
"aa_length": 2211,
"cds_start": 3817,
"cds_end": null,
"cds_length": 6636,
"cdna_start": 4394,
"cdna_end": null,
"cdna_length": 8179,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "XM_047427153.1",
"protein_id": "XP_047283109.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2199,
"cds_start": 3901,
"cds_end": null,
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"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 8143,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3898A>C",
"hgvs_p": "p.Met1300Leu",
"transcript": "XM_047427155.1",
"protein_id": "XP_047283111.1",
"transcript_support_level": null,
"aa_start": 1300,
"aa_end": null,
"aa_length": 2198,
"cds_start": 3898,
"cds_end": null,
"cds_length": 6597,
"cdna_start": 4475,
"cdna_end": null,
"cdna_length": 8140,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3898A>C",
"hgvs_p": "p.Met1300Leu",
"transcript": "XM_047427156.1",
"protein_id": "XP_047283112.1",
"transcript_support_level": null,
"aa_start": 1300,
"aa_end": null,
"aa_length": 2182,
"cds_start": 3898,
"cds_end": null,
"cds_length": 6549,
"cdna_start": 4475,
"cdna_end": null,
"cdna_length": 8092,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "XM_047427157.1",
"protein_id": "XP_047283113.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 2182,
"cds_start": 3901,
"cds_end": null,
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"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 8092,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3757A>C",
"hgvs_p": "p.Met1253Leu",
"transcript": "XM_047427158.1",
"protein_id": "XP_047283114.1",
"transcript_support_level": null,
"aa_start": 1253,
"aa_end": null,
"aa_length": 2175,
"cds_start": 3757,
"cds_end": null,
"cds_length": 6528,
"cdna_start": 3988,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "XM_047427159.1",
"protein_id": "XP_047283115.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 1836,
"cds_start": 3901,
"cds_end": null,
"cds_length": 5511,
"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 6194,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL2",
"gene_hgnc_id": 15585,
"hgvs_c": "c.3901A>C",
"hgvs_p": "p.Met1301Leu",
"transcript": "XM_047427160.1",
"protein_id": "XP_047283116.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 1828,
"cds_start": 3901,
"cds_end": null,
"cds_length": 5487,
"cdna_start": 4478,
"cdna_end": null,
"cdna_length": 6151,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
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