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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-86063520-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=86063520&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 86063520,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "NM_007166.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "NM_007166.4",
"protein_id": "NP_009097.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 652,
"cds_start": null,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000393346.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007166.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000393346.8",
"protein_id": "ENSP00000377015.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 652,
"cds_start": null,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007166.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393346.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000526033.5",
"protein_id": "ENSP00000433846.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 645,
"cds_start": null,
"cds_end": null,
"cds_length": 1938,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000526033.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000532317.5",
"protein_id": "ENSP00000436958.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": null,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000532317.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890386.1",
"protein_id": "ENSP00000560445.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 660,
"cds_start": null,
"cds_end": null,
"cds_length": 1983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890386.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890388.1",
"protein_id": "ENSP00000560447.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 655,
"cds_start": null,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890388.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890390.1",
"protein_id": "ENSP00000560449.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": null,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890390.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890409.1",
"protein_id": "ENSP00000560468.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": null,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890409.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890402.1",
"protein_id": "ENSP00000560461.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 646,
"cds_start": null,
"cds_end": null,
"cds_length": 1941,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890402.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "NM_001206946.2",
"protein_id": "NP_001193875.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 645,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001206946.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 1,
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"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890401.1",
"protein_id": "ENSP00000560460.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 640,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000890401.1"
},
{
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"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
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"gene_symbol": "PICALM",
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"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "NM_001411034.1",
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"aa_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "NM_001411034.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 1,
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"gene_symbol": "PICALM",
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"hgvs_c": "c.130+5131A>C",
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"transcript": "ENST00000356360.9",
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},
{
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],
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"gene_symbol": "PICALM",
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"hgvs_c": "c.130+5131A>C",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890403.1",
"protein_id": "ENSP00000560462.1",
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "PICALM",
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"transcript": "ENST00000890411.1",
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"feature": "ENST00000890411.1"
},
{
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
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"transcript": "ENST00000890399.1",
"protein_id": "ENSP00000560458.1",
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"biotype": "protein_coding",
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},
{
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],
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"exon_count": 19,
"intron_rank": 1,
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"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890408.1",
"protein_id": "ENSP00000560467.1",
"transcript_support_level": null,
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},
{
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"strand": false,
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],
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"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
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},
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],
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"hgvs_c": "c.130+5131A>C",
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},
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],
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"biotype": "protein_coding",
"feature": "ENST00000890393.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PICALM",
"gene_hgnc_id": 15514,
"hgvs_c": "c.130+5131A>C",
"hgvs_p": null,
"transcript": "ENST00000890412.1",
"protein_id": "ENSP00000560471.1",
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890412.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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{
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}
],
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}