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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-8620069-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=8620069&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 8620069,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001388022.1",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3728A>G",
"hgvs_p": "p.His1243Arg",
"transcript": "NM_001388022.1",
"protein_id": "NP_001374951.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1392,
"cds_start": 3728,
"cds_end": null,
"cds_length": 4179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000646038.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388022.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3728A>G",
"hgvs_p": "p.His1243Arg",
"transcript": "ENST00000646038.2",
"protein_id": "ENSP00000495413.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1392,
"cds_start": 3728,
"cds_end": null,
"cds_length": 4179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001388022.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000646038.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3644A>G",
"hgvs_p": "p.His1215Arg",
"transcript": "NM_001388024.1",
"protein_id": "NP_001374953.1",
"transcript_support_level": null,
"aa_start": 1215,
"aa_end": null,
"aa_length": 1364,
"cds_start": 3644,
"cds_end": null,
"cds_length": 4095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388024.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3617A>G",
"hgvs_p": "p.His1206Arg",
"transcript": "NM_001388023.1",
"protein_id": "NP_001374952.1",
"transcript_support_level": null,
"aa_start": 1206,
"aa_end": null,
"aa_length": 1355,
"cds_start": 3617,
"cds_end": null,
"cds_length": 4068,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388023.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3617A>G",
"hgvs_p": "p.His1206Arg",
"transcript": "ENST00000705689.1",
"protein_id": "ENSP00000516162.1",
"transcript_support_level": null,
"aa_start": 1206,
"aa_end": null,
"aa_length": 1355,
"cds_start": 3617,
"cds_end": null,
"cds_length": 4068,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000705689.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3293A>G",
"hgvs_p": "p.His1098Arg",
"transcript": "ENST00000705690.1",
"protein_id": "ENSP00000516163.1",
"transcript_support_level": null,
"aa_start": 1098,
"aa_end": null,
"aa_length": 1247,
"cds_start": 3293,
"cds_end": null,
"cds_length": 3744,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000705690.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3293A>G",
"hgvs_p": "p.His1098Arg",
"transcript": "ENST00000525788.2",
"protein_id": "ENSP00000516161.1",
"transcript_support_level": 5,
"aa_start": 1098,
"aa_end": null,
"aa_length": 1239,
"cds_start": 3293,
"cds_end": null,
"cds_length": 3720,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000525788.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3200A>G",
"hgvs_p": "p.His1067Arg",
"transcript": "NM_014818.2",
"protein_id": "NP_055633.1",
"transcript_support_level": null,
"aa_start": 1067,
"aa_end": null,
"aa_length": 1216,
"cds_start": 3200,
"cds_end": null,
"cds_length": 3651,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014818.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.722A>G",
"hgvs_p": "p.His241Arg",
"transcript": "ENST00000530502.2",
"protein_id": "ENSP00000437234.2",
"transcript_support_level": 3,
"aa_start": 241,
"aa_end": null,
"aa_length": 327,
"cds_start": 722,
"cds_end": null,
"cds_length": 986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000530502.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3728A>G",
"hgvs_p": "p.His1243Arg",
"transcript": "XM_011520504.1",
"protein_id": "XP_011518806.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1392,
"cds_start": 3728,
"cds_end": null,
"cds_length": 4179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520504.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3728A>G",
"hgvs_p": "p.His1243Arg",
"transcript": "XM_011520507.4",
"protein_id": "XP_011518809.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1392,
"cds_start": 3728,
"cds_end": null,
"cds_length": 4179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520507.4"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3728A>G",
"hgvs_p": "p.His1243Arg",
"transcript": "XM_017018629.2",
"protein_id": "XP_016874118.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1392,
"cds_start": 3728,
"cds_end": null,
"cds_length": 4179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017018629.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3728A>G",
"hgvs_p": "p.His1243Arg",
"transcript": "XM_011520508.3",
"protein_id": "XP_011518810.1",
"transcript_support_level": null,
"aa_start": 1243,
"aa_end": null,
"aa_length": 1385,
"cds_start": 3728,
"cds_end": null,
"cds_length": 4158,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520508.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3644A>G",
"hgvs_p": "p.His1215Arg",
"transcript": "XM_011520510.2",
"protein_id": "XP_011518812.1",
"transcript_support_level": null,
"aa_start": 1215,
"aa_end": null,
"aa_length": 1364,
"cds_start": 3644,
"cds_end": null,
"cds_length": 4095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520510.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3644A>G",
"hgvs_p": "p.His1215Arg",
"transcript": "XM_047427940.1",
"protein_id": "XP_047283896.1",
"transcript_support_level": null,
"aa_start": 1215,
"aa_end": null,
"aa_length": 1364,
"cds_start": 3644,
"cds_end": null,
"cds_length": 4095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427940.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3644A>G",
"hgvs_p": "p.His1215Arg",
"transcript": "XM_047427941.1",
"protein_id": "XP_047283897.1",
"transcript_support_level": null,
"aa_start": 1215,
"aa_end": null,
"aa_length": 1364,
"cds_start": 3644,
"cds_end": null,
"cds_length": 4095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427941.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3617A>G",
"hgvs_p": "p.His1206Arg",
"transcript": "XM_047427942.1",
"protein_id": "XP_047283898.1",
"transcript_support_level": null,
"aa_start": 1206,
"aa_end": null,
"aa_length": 1355,
"cds_start": 3617,
"cds_end": null,
"cds_length": 4068,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427942.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3533A>G",
"hgvs_p": "p.His1178Arg",
"transcript": "XM_047427943.1",
"protein_id": "XP_047283899.1",
"transcript_support_level": null,
"aa_start": 1178,
"aa_end": null,
"aa_length": 1327,
"cds_start": 3533,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427943.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3533A>G",
"hgvs_p": "p.His1178Arg",
"transcript": "XM_047427944.1",
"protein_id": "XP_047283900.1",
"transcript_support_level": null,
"aa_start": 1178,
"aa_end": null,
"aa_length": 1327,
"cds_start": 3533,
"cds_end": null,
"cds_length": 3984,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047427944.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3470A>G",
"hgvs_p": "p.His1157Arg",
"transcript": "XM_011520512.1",
"protein_id": "XP_011518814.1",
"transcript_support_level": null,
"aa_start": 1157,
"aa_end": null,
"aa_length": 1306,
"cds_start": 3470,
"cds_end": null,
"cds_length": 3921,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520512.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3470A>G",
"hgvs_p": "p.His1157Arg",
"transcript": "XM_011520513.1",
"protein_id": "XP_011518815.1",
"transcript_support_level": null,
"aa_start": 1157,
"aa_end": null,
"aa_length": 1306,
"cds_start": 3470,
"cds_end": null,
"cds_length": 3921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011520513.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.3470A>G",
"hgvs_p": "p.His1157Arg",
"transcript": "XM_011520514.3",
"protein_id": "XP_011518816.1",
"transcript_support_level": null,
"aa_start": 1157,
"aa_end": null,
"aa_length": 1306,
"cds_start": 3470,
"cds_end": null,
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"phenotype_combined": "not specified",
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}
],
"message": null
}