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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-86277075-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=86277075&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 86277075,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001308007.2",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1062G>A",
"hgvs_p": "p.Gly354Gly",
"transcript": "NM_003797.5",
"protein_id": "NP_003788.2",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 441,
"cds_start": 1062,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000263360.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003797.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1062G>A",
"hgvs_p": "p.Gly354Gly",
"transcript": "ENST00000263360.11",
"protein_id": "ENSP00000263360.6",
"transcript_support_level": 1,
"aa_start": 354,
"aa_end": null,
"aa_length": 441,
"cds_start": 1062,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003797.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000263360.11"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1137G>A",
"hgvs_p": "p.Gly379Gly",
"transcript": "ENST00000351625.10",
"protein_id": "ENSP00000338186.5",
"transcript_support_level": 1,
"aa_start": 379,
"aa_end": null,
"aa_length": 466,
"cds_start": 1137,
"cds_end": null,
"cds_length": 1401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000351625.10"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1062G>A",
"hgvs_p": "p.Gly354Gly",
"transcript": "ENST00000327320.8",
"protein_id": "ENSP00000315587.4",
"transcript_support_level": 1,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1062,
"cds_end": null,
"cds_length": 1203,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000327320.8"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1242G>A",
"hgvs_p": "p.Gly414Gly",
"transcript": "ENST00000673233.3",
"protein_id": "ENSP00000500914.2",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 501,
"cds_start": 1242,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000673233.3"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1137G>A",
"hgvs_p": "p.Gly379Gly",
"transcript": "NM_001308007.2",
"protein_id": "NP_001294936.1",
"transcript_support_level": null,
"aa_start": 379,
"aa_end": null,
"aa_length": 466,
"cds_start": 1137,
"cds_end": null,
"cds_length": 1401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001308007.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1062G>A",
"hgvs_p": "p.Gly354Gly",
"transcript": "ENST00000672825.1",
"protein_id": "ENSP00000500834.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 441,
"cds_start": 1062,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000672825.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1044G>A",
"hgvs_p": "p.Gly348Gly",
"transcript": "NM_001440587.1",
"protein_id": "NP_001427516.1",
"transcript_support_level": null,
"aa_start": 348,
"aa_end": null,
"aa_length": 435,
"cds_start": 1044,
"cds_end": null,
"cds_length": 1308,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440587.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1137G>A",
"hgvs_p": "p.Gly379Gly",
"transcript": "NM_001440588.1",
"protein_id": "NP_001427517.1",
"transcript_support_level": null,
"aa_start": 379,
"aa_end": null,
"aa_length": 428,
"cds_start": 1137,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440588.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1137G>A",
"hgvs_p": "p.Gly379Gly",
"transcript": "NM_001440589.1",
"protein_id": "NP_001427518.1",
"transcript_support_level": null,
"aa_start": 379,
"aa_end": null,
"aa_length": 425,
"cds_start": 1137,
"cds_end": null,
"cds_length": 1278,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440589.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.996G>A",
"hgvs_p": "p.Gly332Gly",
"transcript": "NM_001440591.1",
"protein_id": "NP_001427520.1",
"transcript_support_level": null,
"aa_start": 332,
"aa_end": null,
"aa_length": 419,
"cds_start": 996,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440591.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.969G>A",
"hgvs_p": "p.Gly323Gly",
"transcript": "NM_001440594.1",
"protein_id": "NP_001427523.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 410,
"cds_start": 969,
"cds_end": null,
"cds_length": 1233,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440594.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1137G>A",
"hgvs_p": "p.Gly379Gly",
"transcript": "NM_001440595.1",
"protein_id": "NP_001427524.1",
"transcript_support_level": null,
"aa_start": 379,
"aa_end": null,
"aa_length": 409,
"cds_start": 1137,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440595.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.957G>A",
"hgvs_p": "p.Gly319Gly",
"transcript": "ENST00000707108.1",
"protein_id": "ENSP00000516737.1",
"transcript_support_level": null,
"aa_start": 319,
"aa_end": null,
"aa_length": 406,
"cds_start": 957,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000707108.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1062G>A",
"hgvs_p": "p.Gly354Gly",
"transcript": "NM_001440586.1",
"protein_id": "NP_001427515.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 400,
"cds_start": 1062,
"cds_end": null,
"cds_length": 1203,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440586.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.1062G>A",
"hgvs_p": "p.Gly354Gly",
"transcript": "NM_001440597.1",
"protein_id": "NP_001427526.1",
"transcript_support_level": null,
"aa_start": 354,
"aa_end": null,
"aa_length": 390,
"cds_start": 1062,
"cds_end": null,
"cds_length": 1173,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440597.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.891G>A",
"hgvs_p": "p.Gly297Gly",
"transcript": "NM_001440598.1",
"protein_id": "NP_001427527.1",
"transcript_support_level": null,
"aa_start": 297,
"aa_end": null,
"aa_length": 384,
"cds_start": 891,
"cds_end": null,
"cds_length": 1155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440598.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.870G>A",
"hgvs_p": "p.Gly290Gly",
"transcript": "NM_001440599.1",
"protein_id": "NP_001427528.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 377,
"cds_start": 870,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440599.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.969G>A",
"hgvs_p": "p.Gly323Gly",
"transcript": "NM_001440600.1",
"protein_id": "NP_001427529.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 372,
"cds_start": 969,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440600.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.822G>A",
"hgvs_p": "p.Gly274Gly",
"transcript": "NM_001330334.2",
"protein_id": "NP_001317263.1",
"transcript_support_level": null,
"aa_start": 274,
"aa_end": null,
"aa_length": 361,
"cds_start": 822,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001330334.2"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.822G>A",
"hgvs_p": "p.Gly274Gly",
"transcript": "ENST00000528180.5",
"protein_id": "ENSP00000431778.1",
"transcript_support_level": 5,
"aa_start": 274,
"aa_end": null,
"aa_length": 361,
"cds_start": 822,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000528180.5"
},
{
"aa_ref": "G",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EED",
"gene_hgnc_id": 3188,
"hgvs_c": "c.816G>A",
"hgvs_p": "p.Gly272Gly",
"transcript": "NM_001440601.1",
"protein_id": "NP_001427530.1",
"transcript_support_level": null,
"aa_start": 272,
"aa_end": null,
"aa_length": 359,
"cds_start": 816,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001440601.1"
},
{
"aa_ref": "G",
"aa_alt": "G",
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"protein_coding": true,
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{
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"pathogenicity_classification_combined": "Benign",
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}
],
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}