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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 11-8640969-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=8640969&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "11",
"pos": 8640969,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000646038.2",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "NM_001388022.1",
"protein_id": "NP_001374951.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 1392,
"cds_start": 1406,
"cds_end": null,
"cds_length": 4179,
"cdna_start": 2018,
"cdna_end": null,
"cdna_length": 10695,
"mane_select": "ENST00000646038.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "ENST00000646038.2",
"protein_id": "ENSP00000495413.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 1392,
"cds_start": 1406,
"cds_end": null,
"cds_length": 4179,
"cdna_start": 2018,
"cdna_end": null,
"cdna_length": 10695,
"mane_select": "NM_001388022.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "NM_001388024.1",
"protein_id": "NP_001374953.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 1364,
"cds_start": 1406,
"cds_end": null,
"cds_length": 4095,
"cdna_start": 2454,
"cdna_end": null,
"cdna_length": 11047,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1295A>T",
"hgvs_p": "p.His432Leu",
"transcript": "NM_001388023.1",
"protein_id": "NP_001374952.1",
"transcript_support_level": null,
"aa_start": 432,
"aa_end": null,
"aa_length": 1355,
"cds_start": 1295,
"cds_end": null,
"cds_length": 4068,
"cdna_start": 1907,
"cdna_end": null,
"cdna_length": 10584,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1295A>T",
"hgvs_p": "p.His432Leu",
"transcript": "ENST00000705689.1",
"protein_id": "ENSP00000516162.1",
"transcript_support_level": null,
"aa_start": 432,
"aa_end": null,
"aa_length": 1355,
"cds_start": 1295,
"cds_end": null,
"cds_length": 4068,
"cdna_start": 1874,
"cdna_end": null,
"cdna_length": 10551,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.971A>T",
"hgvs_p": "p.His324Leu",
"transcript": "ENST00000705690.1",
"protein_id": "ENSP00000516163.1",
"transcript_support_level": null,
"aa_start": 324,
"aa_end": null,
"aa_length": 1247,
"cds_start": 971,
"cds_end": null,
"cds_length": 3744,
"cdna_start": 1166,
"cdna_end": null,
"cdna_length": 6344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.971A>T",
"hgvs_p": "p.His324Leu",
"transcript": "ENST00000525788.2",
"protein_id": "ENSP00000516161.1",
"transcript_support_level": 5,
"aa_start": 324,
"aa_end": null,
"aa_length": 1239,
"cds_start": 971,
"cds_end": null,
"cds_length": 3720,
"cdna_start": 1494,
"cdna_end": null,
"cdna_length": 10202,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.971A>T",
"hgvs_p": "p.His324Leu",
"transcript": "NM_014818.2",
"protein_id": "NP_055633.1",
"transcript_support_level": null,
"aa_start": 324,
"aa_end": null,
"aa_length": 1216,
"cds_start": 971,
"cds_end": null,
"cds_length": 3651,
"cdna_start": 1216,
"cdna_end": null,
"cdna_length": 9800,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "XM_011520504.1",
"protein_id": "XP_011518806.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 1392,
"cds_start": 1406,
"cds_end": null,
"cds_length": 4179,
"cdna_start": 2054,
"cdna_end": null,
"cdna_length": 10731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "XM_011520507.4",
"protein_id": "XP_011518809.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 1392,
"cds_start": 1406,
"cds_end": null,
"cds_length": 4179,
"cdna_start": 1951,
"cdna_end": null,
"cdna_length": 10628,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
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"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "XM_017018629.2",
"protein_id": "XP_016874118.1",
"transcript_support_level": null,
"aa_start": 469,
"aa_end": null,
"aa_length": 1392,
"cds_start": 1406,
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"cdna_start": 2418,
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"mane_select": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 14,
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"intron_rank": null,
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"gene_symbol": "TRIM66",
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"hgvs_p": "p.His469Leu",
"transcript": "XM_011520508.3",
"protein_id": "XP_011518810.1",
"transcript_support_level": null,
"aa_start": 469,
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"cds_start": 1406,
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"cdna_start": 2018,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
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"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "XM_011520509.2",
"protein_id": "XP_011518811.1",
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"aa_end": null,
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"cds_start": 1406,
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"cdna_start": 2018,
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},
{
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"protein_coding": true,
"strand": false,
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],
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"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1406A>T",
"hgvs_p": "p.His469Leu",
"transcript": "XM_047427940.1",
"protein_id": "XP_047283896.1",
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},
{
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"strand": false,
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],
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"intron_rank": null,
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"gene_symbol": "TRIM66",
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"hgvs_c": "c.1406A>T",
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"transcript": "XM_047427941.1",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1295A>T",
"hgvs_p": "p.His432Leu",
"transcript": "XM_047427942.1",
"protein_id": "XP_047283898.1",
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},
{
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"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "TRIM66",
"gene_hgnc_id": 29005,
"hgvs_c": "c.1295A>T",
"hgvs_p": "p.His432Leu",
"transcript": "XM_047427943.1",
"protein_id": "XP_047283899.1",
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},
{
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],
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"gene_symbol": "TRIM66",
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},
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],
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},
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],
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},
{
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"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "TRIM66",
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"hgvs_c": "c.1148A>T",
"hgvs_p": "p.His383Leu",
"transcript": "XM_011520514.3",
"protein_id": "XP_011518816.1",
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},
{
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"protein_coding": true,
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"consequences": [
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],
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"gene_symbol": "TRIM66",
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