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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 11-9025798-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=11&pos=9025798&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "11",
      "pos": 9025798,
      "ref": "C",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_001367977.2",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2758G>C",
          "hgvs_p": "p.Ala920Pro",
          "transcript": "NM_001367977.2",
          "protein_id": "NP_001354906.1",
          "transcript_support_level": null,
          "aa_start": 920,
          "aa_end": null,
          "aa_length": 1028,
          "cds_start": 2758,
          "cds_end": null,
          "cds_length": 3087,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000649792.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001367977.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2758G>C",
          "hgvs_p": "p.Ala920Pro",
          "transcript": "ENST00000649792.2",
          "protein_id": "ENSP00000497523.1",
          "transcript_support_level": null,
          "aa_start": 920,
          "aa_end": null,
          "aa_length": 1028,
          "cds_start": 2758,
          "cds_end": null,
          "cds_length": 3087,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001367977.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000649792.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2095G>C",
          "hgvs_p": "p.Ala699Pro",
          "transcript": "ENST00000450649.6",
          "protein_id": "ENSP00000415187.2",
          "transcript_support_level": 1,
          "aa_start": 699,
          "aa_end": null,
          "aa_length": 807,
          "cds_start": 2095,
          "cds_end": null,
          "cds_length": 2424,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000450649.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2671G>C",
          "hgvs_p": "p.Ala891Pro",
          "transcript": "NM_001330199.3",
          "protein_id": "NP_001317128.1",
          "transcript_support_level": null,
          "aa_start": 891,
          "aa_end": null,
          "aa_length": 999,
          "cds_start": 2671,
          "cds_end": null,
          "cds_length": 3000,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330199.3"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2671G>C",
          "hgvs_p": "p.Ala891Pro",
          "transcript": "ENST00000309263.7",
          "protein_id": "ENSP00000310658.3",
          "transcript_support_level": 5,
          "aa_start": 891,
          "aa_end": null,
          "aa_length": 999,
          "cds_start": 2671,
          "cds_end": null,
          "cds_length": 3000,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000309263.7"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2665G>C",
          "hgvs_p": "p.Ala889Pro",
          "transcript": "ENST00000936074.1",
          "protein_id": "ENSP00000606133.1",
          "transcript_support_level": null,
          "aa_start": 889,
          "aa_end": null,
          "aa_length": 997,
          "cds_start": 2665,
          "cds_end": null,
          "cds_length": 2994,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000936074.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2653G>C",
          "hgvs_p": "p.Ala885Pro",
          "transcript": "ENST00000950246.1",
          "protein_id": "ENSP00000620305.1",
          "transcript_support_level": null,
          "aa_start": 885,
          "aa_end": null,
          "aa_length": 993,
          "cds_start": 2653,
          "cds_end": null,
          "cds_length": 2982,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950246.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2641G>C",
          "hgvs_p": "p.Ala881Pro",
          "transcript": "ENST00000950245.1",
          "protein_id": "ENSP00000620304.1",
          "transcript_support_level": null,
          "aa_start": 881,
          "aa_end": null,
          "aa_length": 989,
          "cds_start": 2641,
          "cds_end": null,
          "cds_length": 2970,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950245.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2587G>C",
          "hgvs_p": "p.Ala863Pro",
          "transcript": "NM_020974.4",
          "protein_id": "NP_066025.2",
          "transcript_support_level": null,
          "aa_start": 863,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": 2587,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_020974.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2587G>C",
          "hgvs_p": "p.Ala863Pro",
          "transcript": "ENST00000520467.5",
          "protein_id": "ENSP00000429969.1",
          "transcript_support_level": 2,
          "aa_start": 863,
          "aa_end": null,
          "aa_length": 971,
          "cds_start": 2587,
          "cds_end": null,
          "cds_length": 2916,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000520467.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2554G>C",
          "hgvs_p": "p.Ala852Pro",
          "transcript": "ENST00000899097.1",
          "protein_id": "ENSP00000569156.1",
          "transcript_support_level": null,
          "aa_start": 852,
          "aa_end": null,
          "aa_length": 960,
          "cds_start": 2554,
          "cds_end": null,
          "cds_length": 2883,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000899097.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2512G>C",
          "hgvs_p": "p.Ala838Pro",
          "transcript": "ENST00000936075.1",
          "protein_id": "ENSP00000606134.1",
          "transcript_support_level": null,
          "aa_start": 838,
          "aa_end": null,
          "aa_length": 946,
          "cds_start": 2512,
          "cds_end": null,
          "cds_length": 2841,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000936075.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2500G>C",
          "hgvs_p": "p.Ala834Pro",
          "transcript": "ENST00000950248.1",
          "protein_id": "ENSP00000620307.1",
          "transcript_support_level": null,
          "aa_start": 834,
          "aa_end": null,
          "aa_length": 942,
          "cds_start": 2500,
          "cds_end": null,
          "cds_length": 2829,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950248.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2431G>C",
          "hgvs_p": "p.Ala811Pro",
          "transcript": "ENST00000899094.1",
          "protein_id": "ENSP00000569153.1",
          "transcript_support_level": null,
          "aa_start": 811,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 2431,
          "cds_end": null,
          "cds_length": 2760,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000899094.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2293G>C",
          "hgvs_p": "p.Ala765Pro",
          "transcript": "ENST00000950244.1",
          "protein_id": "ENSP00000620303.1",
          "transcript_support_level": null,
          "aa_start": 765,
          "aa_end": null,
          "aa_length": 914,
          "cds_start": 2293,
          "cds_end": null,
          "cds_length": 2745,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950244.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2383G>C",
          "hgvs_p": "p.Ala795Pro",
          "transcript": "ENST00000950247.1",
          "protein_id": "ENSP00000620306.1",
          "transcript_support_level": null,
          "aa_start": 795,
          "aa_end": null,
          "aa_length": 903,
          "cds_start": 2383,
          "cds_end": null,
          "cds_length": 2712,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950247.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2374G>C",
          "hgvs_p": "p.Ala792Pro",
          "transcript": "ENST00000950243.1",
          "protein_id": "ENSP00000620302.1",
          "transcript_support_level": null,
          "aa_start": 792,
          "aa_end": null,
          "aa_length": 900,
          "cds_start": 2374,
          "cds_end": null,
          "cds_length": 2703,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950243.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2314G>C",
          "hgvs_p": "p.Ala772Pro",
          "transcript": "ENST00000899096.1",
          "protein_id": "ENSP00000569155.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 880,
          "cds_start": 2314,
          "cds_end": null,
          "cds_length": 2643,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000899096.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2293G>C",
          "hgvs_p": "p.Ala765Pro",
          "transcript": "ENST00000899093.1",
          "protein_id": "ENSP00000569152.1",
          "transcript_support_level": null,
          "aa_start": 765,
          "aa_end": null,
          "aa_length": 873,
          "cds_start": 2293,
          "cds_end": null,
          "cds_length": 2622,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000899093.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SCUBE2",
          "gene_hgnc_id": 30425,
          "hgvs_c": "c.2233G>C",
          "hgvs_p": "p.Ala745Pro",
          "transcript": "ENST00000950242.1",
          "protein_id": "ENSP00000620301.1",
          "transcript_support_level": null,
          "aa_start": 745,
          "aa_end": null,
          "aa_length": 853,
          "cds_start": 2233,
          "cds_end": null,
          "cds_length": 2562,
          "cdna_start": null,
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      "computational_score_selected": 0.8741163015365601,
      "computational_prediction_selected": "Pathogenic",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.23000000417232513,
      "splice_prediction_selected": "Uncertain_significance",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.648,
      "revel_prediction": "Pathogenic",
      "alphamissense_score": 0.9966,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.08,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 7.813,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0.23,
      "spliceai_max_prediction": "Uncertain_significance",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 4,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3_Moderate",
      "acmg_by_gene": [
        {
          "score": 4,
          "benign_score": 0,
          "pathogenic_score": 4,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001367977.2",
          "gene_symbol": "SCUBE2",
          "hgnc_id": 30425,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.2758G>C",
          "hgvs_p": "p.Ala920Pro"
        },
        {
          "score": 4,
          "benign_score": 0,
          "pathogenic_score": 4,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000531592.1",
          "gene_symbol": "NRIP3-DT",
          "hgnc_id": 55524,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.383-4409C>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}