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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-106318355-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=106318355&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 106318355,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_152772.3",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "NM_152772.3",
"protein_id": "NP_689985.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000299045.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_152772.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000299045.8",
"protein_id": "ENSP00000299045.3",
"transcript_support_level": 1,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_152772.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000299045.8"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000546625.5",
"protein_id": "ENSP00000449123.1",
"transcript_support_level": 1,
"aa_start": 102,
"aa_end": null,
"aa_length": 272,
"cds_start": 305,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000546625.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000718461.1",
"protein_id": "ENSP00000520839.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000718461.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000910255.1",
"protein_id": "ENSP00000580314.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910255.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000910256.1",
"protein_id": "ENSP00000580315.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910256.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "NM_001286262.2",
"protein_id": "NP_001273191.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 266,
"cds_start": 305,
"cds_end": null,
"cds_length": 801,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286262.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000547153.5",
"protein_id": "ENSP00000448952.1",
"transcript_support_level": 2,
"aa_start": 102,
"aa_end": null,
"aa_length": 266,
"cds_start": 305,
"cds_end": null,
"cds_length": 801,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000547153.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000553098.5",
"protein_id": "ENSP00000448629.1",
"transcript_support_level": 5,
"aa_start": 102,
"aa_end": null,
"aa_length": 233,
"cds_start": 305,
"cds_end": null,
"cds_length": 702,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000553098.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "ENST00000551802.5",
"protein_id": "ENSP00000447174.1",
"transcript_support_level": 3,
"aa_start": 102,
"aa_end": null,
"aa_length": 130,
"cds_start": 305,
"cds_end": null,
"cds_length": 395,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000551802.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_005268767.6",
"protein_id": "XP_005268824.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005268767.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_005268768.5",
"protein_id": "XP_005268825.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005268768.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_011538129.4",
"protein_id": "XP_011536431.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011538129.4"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_011538130.3",
"protein_id": "XP_011536432.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011538130.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_017019127.3",
"protein_id": "XP_016874616.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017019127.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_017019129.3",
"protein_id": "XP_016874618.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017019129.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_017019130.3",
"protein_id": "XP_016874619.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017019130.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_017019131.2",
"protein_id": "XP_016874620.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017019131.2"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_047428666.1",
"protein_id": "XP_047284622.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047428666.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.305G>T",
"hgvs_p": "p.Arg102Leu",
"transcript": "XM_047428667.1",
"protein_id": "XP_047284623.1",
"transcript_support_level": null,
"aa_start": 102,
"aa_end": null,
"aa_length": 519,
"cds_start": 305,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047428667.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.110G>T",
"hgvs_p": "p.Arg37Leu",
"transcript": "XM_017019133.3",
"protein_id": "XP_016874622.1",
"transcript_support_level": null,
"aa_start": 37,
"aa_end": null,
"aa_length": 454,
"cds_start": 110,
"cds_end": null,
"cds_length": 1365,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017019133.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TCP11L2",
"gene_hgnc_id": 28627,
"hgvs_c": "c.110G>T",
"hgvs_p": "p.Arg37Leu",
"transcript": "XM_047428668.1",
"protein_id": "XP_047284624.1",
"transcript_support_level": null,
"aa_start": 37,
"aa_end": null,
"aa_length": 454,
"cds_start": 110,
"cds_end": null,
"cds_length": 1365,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
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}
],
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}