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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-10702061-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=10702061&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 2,
"criteria": [
"PM2",
"BP4_Moderate"
],
"effects": [
"missense_variant"
],
"gene_symbol": "YBX3",
"hgnc_id": 2428,
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"inheritance_mode": "AR",
"pathogenic_score": 2,
"score": 0,
"transcript": "NM_003651.5",
"verdict": "Uncertain_significance"
}
],
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,BP4_Moderate",
"acmg_score": 0,
"allele_count_reference_population": 1,
"alphamissense_prediction": null,
"alphamissense_score": 0.1182,
"alt": "A",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.5,
"chr": "12",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": "Benign",
"computational_score_selected": 0.25800997018814087,
"computational_source_selected": "MetaRNN",
"consequences": [
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 372,
"aa_ref": "S",
"aa_start": 318,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1931,
"cdna_start": 1164,
"cds_end": null,
"cds_length": 1119,
"cds_start": 952,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "NM_003651.5",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000228251.9",
"protein_coding": true,
"protein_id": "NP_003642.3",
"strand": false,
"transcript": "NM_003651.5",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 372,
"aa_ref": "S",
"aa_start": 318,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 1931,
"cdna_start": 1164,
"cds_end": null,
"cds_length": 1119,
"cds_start": 952,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000228251.9",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_003651.5",
"protein_coding": true,
"protein_id": "ENSP00000228251.4",
"strand": false,
"transcript": "ENST00000228251.9",
"transcript_support_level": 1
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 303,
"aa_ref": "S",
"aa_start": 249,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1708,
"cdna_start": 941,
"cds_end": null,
"cds_length": 912,
"cds_start": 745,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000279550.11",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.745A>T",
"hgvs_p": "p.Ser249Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000279550.7",
"strand": false,
"transcript": "ENST00000279550.11",
"transcript_support_level": 1
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 437,
"aa_ref": "S",
"aa_start": 383,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2124,
"cdna_start": 1357,
"cds_end": null,
"cds_length": 1314,
"cds_start": 1147,
"consequences": [
"missense_variant"
],
"exon_count": 12,
"exon_rank": 10,
"exon_rank_end": null,
"feature": "ENST00000955210.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.1147A>T",
"hgvs_p": "p.Ser383Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625269.1",
"strand": false,
"transcript": "ENST00000955210.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 382,
"aa_ref": "S",
"aa_start": 328,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1961,
"cdna_start": 1194,
"cds_end": null,
"cds_length": 1149,
"cds_start": 982,
"consequences": [
"missense_variant"
],
"exon_count": 11,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "ENST00000955208.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.982A>T",
"hgvs_p": "p.Ser328Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625267.1",
"strand": false,
"transcript": "ENST00000955208.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 378,
"aa_ref": "S",
"aa_start": 324,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1956,
"cdna_start": 1189,
"cds_end": null,
"cds_length": 1137,
"cds_start": 970,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000895014.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.970A>T",
"hgvs_p": "p.Ser324Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000565073.1",
"strand": false,
"transcript": "ENST00000895014.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 378,
"aa_ref": "S",
"aa_start": 324,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1946,
"cdna_start": 1182,
"cds_end": null,
"cds_length": 1137,
"cds_start": 970,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000955211.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.970A>T",
"hgvs_p": "p.Ser324Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625270.1",
"strand": false,
"transcript": "ENST00000955211.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 372,
"aa_ref": "S",
"aa_start": 318,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3413,
"cdna_start": 1171,
"cds_end": null,
"cds_length": 1119,
"cds_start": 952,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000895017.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000565076.1",
"strand": false,
"transcript": "ENST00000895017.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 372,
"aa_ref": "S",
"aa_start": 318,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1555,
"cdna_start": 1171,
"cds_end": null,
"cds_length": 1119,
"cds_start": 952,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000895018.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000565077.1",
"strand": false,
"transcript": "ENST00000895018.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 372,
"aa_ref": "S",
"aa_start": 318,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1987,
"cdna_start": 1229,
"cds_end": null,
"cds_length": 1119,
"cds_start": 952,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000932591.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000602650.1",
"strand": false,
"transcript": "ENST00000932591.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 371,
"aa_ref": "S",
"aa_start": 317,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1993,
"cdna_start": 1226,
"cds_end": null,
"cds_length": 1116,
"cds_start": 949,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000895012.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.949A>T",
"hgvs_p": "p.Ser317Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000565071.1",
"strand": false,
"transcript": "ENST00000895012.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 370,
"aa_ref": "S",
"aa_start": 318,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1933,
"cdna_start": 1170,
"cds_end": null,
"cds_length": 1113,
"cds_start": 952,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000932592.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.952A>T",
"hgvs_p": "p.Ser318Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000602651.1",
"strand": false,
"transcript": "ENST00000932592.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 369,
"aa_ref": "S",
"aa_start": 315,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1994,
"cdna_start": 1220,
"cds_end": null,
"cds_length": 1110,
"cds_start": 943,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000895010.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.943A>T",
"hgvs_p": "p.Ser315Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000565069.1",
"strand": false,
"transcript": "ENST00000895010.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 369,
"aa_ref": "S",
"aa_start": 315,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1921,
"cdna_start": 1155,
"cds_end": null,
"cds_length": 1110,
"cds_start": 943,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000955209.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.943A>T",
"hgvs_p": "p.Ser315Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625268.1",
"strand": false,
"transcript": "ENST00000955209.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 368,
"aa_ref": "S",
"aa_start": 314,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1926,
"cdna_start": 1159,
"cds_end": null,
"cds_length": 1107,
"cds_start": 940,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000895015.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.940A>T",
"hgvs_p": "p.Ser314Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000565074.1",
"strand": false,
"transcript": "ENST00000895015.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 368,
"aa_ref": "S",
"aa_start": 314,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1914,
"cdna_start": 1150,
"cds_end": null,
"cds_length": 1107,
"cds_start": 940,
"consequences": [
"missense_variant"
],
"exon_count": 11,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "ENST00000955212.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.940A>T",
"hgvs_p": "p.Ser314Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625271.1",
"strand": false,
"transcript": "ENST00000955212.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 362,
"aa_ref": "S",
"aa_start": 308,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1382,
"cdna_start": 1139,
"cds_end": null,
"cds_length": 1089,
"cds_start": 922,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000932594.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.922A>T",
"hgvs_p": "p.Ser308Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000602653.1",
"strand": false,
"transcript": "ENST00000932594.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 336,
"aa_ref": "S",
"aa_start": 282,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1683,
"cdna_start": 1056,
"cds_end": null,
"cds_length": 1011,
"cds_start": 844,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000955215.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.844A>T",
"hgvs_p": "p.Ser282Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625274.1",
"strand": false,
"transcript": "ENST00000955215.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 331,
"aa_ref": "S",
"aa_start": 277,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1820,
"cdna_start": 1041,
"cds_end": null,
"cds_length": 996,
"cds_start": 829,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000955201.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.829A>T",
"hgvs_p": "p.Ser277Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625260.1",
"strand": false,
"transcript": "ENST00000955201.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 330,
"aa_ref": "S",
"aa_start": 276,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1816,
"cdna_start": 1050,
"cds_end": null,
"cds_length": 993,
"cds_start": 826,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000955202.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.826A>T",
"hgvs_p": "p.Ser276Cys",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000625261.1",
"strand": false,
"transcript": "ENST00000955202.1",
"transcript_support_level": null
},
{
"aa_alt": "C",
"aa_end": null,
"aa_length": 314,
"aa_ref": "S",
"aa_start": 260,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1759,
"cdna_start": 994,
"cds_end": null,
"cds_length": 945,
"cds_start": 778,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000955206.1",
"gene_hgnc_id": 2428,
"gene_symbol": "YBX3",
"hgvs_c": "c.778A>T",
"hgvs_p": "p.Ser260Cys",
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