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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-112949145-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=112949145&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 112949145,
"ref": "T",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000228928.12",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "NM_006187.4",
"protein_id": "NP_006178.2",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 1087,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3264,
"cdna_start": 1371,
"cdna_end": null,
"cdna_length": 6599,
"mane_select": "ENST00000228928.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "ENST00000228928.12",
"protein_id": "ENSP00000228928.7",
"transcript_support_level": 1,
"aa_start": 438,
"aa_end": null,
"aa_length": 1087,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3264,
"cdna_start": 1371,
"cdna_end": null,
"cdna_length": 6599,
"mane_select": "NM_006187.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "ENST00000679493.1",
"protein_id": "ENSP00000506397.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 1130,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3393,
"cdna_start": 1321,
"cdna_end": null,
"cdna_length": 6517,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "ENST00000681346.1",
"protein_id": "ENSP00000505939.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 1120,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3363,
"cdna_start": 1561,
"cdna_end": null,
"cdna_length": 6898,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "ENST00000680044.1",
"protein_id": "ENSP00000505627.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 1089,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3270,
"cdna_start": 1423,
"cdna_end": null,
"cdna_length": 6657,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1236T>A",
"hgvs_p": "p.Ile412Ile",
"transcript": "ENST00000679354.1",
"protein_id": "ENSP00000505880.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 1061,
"cds_start": 1236,
"cds_end": null,
"cds_length": 3186,
"cdna_start": 1261,
"cdna_end": null,
"cdna_length": 6483,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "NM_001410984.1",
"protein_id": "NP_001397913.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 1036,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3111,
"cdna_start": 1371,
"cdna_end": null,
"cdna_length": 6446,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "ENST00000681497.1",
"protein_id": "ENSP00000505225.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 1036,
"cds_start": 1314,
"cds_end": null,
"cds_length": 3111,
"cdna_start": 1412,
"cdna_end": null,
"cdna_length": 9696,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "c.1314T>A",
"hgvs_p": "p.Ile438Ile",
"transcript": "ENST00000680438.1",
"protein_id": "ENSP00000505969.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 928,
"cds_start": 1314,
"cds_end": null,
"cds_length": 2787,
"cdna_start": 1359,
"cdna_end": null,
"cdna_length": 3027,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1321T>A",
"hgvs_p": null,
"transcript": "ENST00000546638.2",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1536,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.*965T>A",
"hgvs_p": null,
"transcript": "ENST00000679505.1",
"protein_id": "ENSP00000506118.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6668,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.*589T>A",
"hgvs_p": null,
"transcript": "ENST00000679517.1",
"protein_id": "ENSP00000506294.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 6423,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.*737T>A",
"hgvs_p": null,
"transcript": "ENST00000679547.1",
"protein_id": "ENSP00000506567.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 6316,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.*965T>A",
"hgvs_p": null,
"transcript": "ENST00000679562.1",
"protein_id": "ENSP00000505418.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000679812.1",
"protein_id": "ENSP00000505154.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 7017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000679912.1",
"protein_id": "ENSP00000504871.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000680090.1",
"protein_id": "ENSP00000506611.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 7007,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.776T>A",
"hgvs_p": null,
"transcript": "ENST00000680153.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 2654,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000680177.1",
"protein_id": "ENSP00000505925.1",
"transcript_support_level": null,
"aa_start": null,
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"biotype": null,
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},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000680293.1",
"protein_id": "ENSP00000505651.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000681002.1",
"protein_id": "ENSP00000506106.1",
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.1314T>A",
"hgvs_p": null,
"transcript": "ENST00000681007.1",
"protein_id": "ENSP00000505477.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3892,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "OAS3",
"gene_hgnc_id": 8088,
"hgvs_c": "n.2616T>A",
"hgvs_p": null,
"transcript": "ENST00000681105.1",
"protein_id": null,
"transcript_support_level": null,
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}