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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-22469744-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=22469744&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 22469744,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001385322.1",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2498A>T",
"hgvs_p": "p.Asp833Val",
"transcript": "NM_001286176.2",
"protein_id": "NP_001273105.1",
"transcript_support_level": null,
"aa_start": 833,
"aa_end": null,
"aa_length": 1051,
"cds_start": 2498,
"cds_end": null,
"cds_length": 3156,
"cdna_start": 2750,
"cdna_end": null,
"cdna_length": 4585,
"mane_select": "ENST00000446597.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286176.2"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2498A>T",
"hgvs_p": "p.Asp833Val",
"transcript": "ENST00000446597.6",
"protein_id": "ENSP00000388756.1",
"transcript_support_level": 1,
"aa_start": 833,
"aa_end": null,
"aa_length": 1051,
"cds_start": 2498,
"cds_end": null,
"cds_length": 3156,
"cdna_start": 2750,
"cdna_end": null,
"cdna_length": 4585,
"mane_select": "NM_001286176.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000446597.6"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2504A>T",
"hgvs_p": "p.Asp835Val",
"transcript": "ENST00000536386.5",
"protein_id": "ENSP00000439392.1",
"transcript_support_level": 1,
"aa_start": 835,
"aa_end": null,
"aa_length": 1053,
"cds_start": 2504,
"cds_end": null,
"cds_length": 3162,
"cdna_start": 2623,
"cdna_end": null,
"cdna_length": 3496,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000536386.5"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2471A>T",
"hgvs_p": "p.Asp824Val",
"transcript": "ENST00000396028.6",
"protein_id": "ENSP00000379345.2",
"transcript_support_level": 1,
"aa_start": 824,
"aa_end": null,
"aa_length": 1042,
"cds_start": 2471,
"cds_end": null,
"cds_length": 3129,
"cdna_start": 2590,
"cdna_end": null,
"cdna_length": 3463,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396028.6"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2498A>T",
"hgvs_p": "p.Asp833Val",
"transcript": "ENST00000333957.8",
"protein_id": "ENSP00000334229.4",
"transcript_support_level": 1,
"aa_start": 833,
"aa_end": null,
"aa_length": 1000,
"cds_start": 2498,
"cds_end": null,
"cds_length": 3003,
"cdna_start": 2754,
"cdna_end": null,
"cdna_length": 4436,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000333957.8"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2762A>T",
"hgvs_p": "p.Asp921Val",
"transcript": "ENST00000960574.1",
"protein_id": "ENSP00000630633.1",
"transcript_support_level": null,
"aa_start": 921,
"aa_end": null,
"aa_length": 1139,
"cds_start": 2762,
"cds_end": null,
"cds_length": 3420,
"cdna_start": 2804,
"cdna_end": null,
"cdna_length": 4630,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960574.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2723A>T",
"hgvs_p": "p.Asp908Val",
"transcript": "ENST00000906362.1",
"protein_id": "ENSP00000576421.1",
"transcript_support_level": null,
"aa_start": 908,
"aa_end": null,
"aa_length": 1126,
"cds_start": 2723,
"cds_end": null,
"cds_length": 3381,
"cdna_start": 2766,
"cdna_end": null,
"cdna_length": 4601,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906362.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2723A>T",
"hgvs_p": "p.Asp908Val",
"transcript": "ENST00000960568.1",
"protein_id": "ENSP00000630627.1",
"transcript_support_level": null,
"aa_start": 908,
"aa_end": null,
"aa_length": 1126,
"cds_start": 2723,
"cds_end": null,
"cds_length": 3381,
"cdna_start": 2935,
"cdna_end": null,
"cdna_length": 4774,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960568.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "NM_001385322.1",
"protein_id": "NP_001372251.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1115,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2942,
"cdna_end": null,
"cdna_length": 4777,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385322.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "ENST00000906354.1",
"protein_id": "ENSP00000576413.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1115,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 2908,
"cdna_end": null,
"cdna_length": 4743,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906354.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "ENST00000960569.1",
"protein_id": "ENSP00000630628.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1115,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3348,
"cdna_start": 3051,
"cdna_end": null,
"cdna_length": 4877,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960569.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "ENST00000960565.1",
"protein_id": "ENSP00000630624.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1105,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3318,
"cdna_start": 3075,
"cdna_end": null,
"cdna_length": 4876,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960565.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "ENST00000906359.1",
"protein_id": "ENSP00000576418.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1098,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3297,
"cdna_start": 2760,
"cdna_end": null,
"cdna_length": 4544,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906359.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2537A>T",
"hgvs_p": "p.Asp846Val",
"transcript": "NM_001385323.1",
"protein_id": "NP_001372252.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2537,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 2789,
"cdna_end": null,
"cdna_length": 4624,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001385323.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "ENST00000906352.1",
"protein_id": "ENSP00000576411.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 2918,
"cdna_end": null,
"cdna_length": 4600,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906352.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2537A>T",
"hgvs_p": "p.Asp846Val",
"transcript": "ENST00000906358.1",
"protein_id": "ENSP00000576417.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2537,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 2703,
"cdna_end": null,
"cdna_length": 4538,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906358.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2690A>T",
"hgvs_p": "p.Asp897Val",
"transcript": "ENST00000960566.1",
"protein_id": "ENSP00000630625.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2690,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 3065,
"cdna_end": null,
"cdna_length": 4738,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960566.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2537A>T",
"hgvs_p": "p.Asp846Val",
"transcript": "ENST00000960573.1",
"protein_id": "ENSP00000630632.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 1064,
"cds_start": 2537,
"cds_end": null,
"cds_length": 3195,
"cdna_start": 2592,
"cdna_end": null,
"cdna_length": 4418,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960573.1"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2537A>T",
"hgvs_p": "p.Asp846Val",
"transcript": "NM_001286175.2",
"protein_id": "NP_001273104.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 1054,
"cds_start": 2537,
"cds_end": null,
"cds_length": 3165,
"cdna_start": 2789,
"cdna_end": null,
"cdna_length": 4594,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286175.2"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2537A>T",
"hgvs_p": "p.Asp846Val",
"transcript": "ENST00000545552.5",
"protein_id": "ENSP00000443204.1",
"transcript_support_level": 2,
"aa_start": 846,
"aa_end": null,
"aa_length": 1054,
"cds_start": 2537,
"cds_end": null,
"cds_length": 3165,
"cdna_start": 2739,
"cdna_end": null,
"cdna_length": 3471,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000545552.5"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2504A>T",
"hgvs_p": "p.Asp835Val",
"transcript": "NM_001286173.2",
"protein_id": "NP_001273102.1",
"transcript_support_level": null,
"aa_start": 835,
"aa_end": null,
"aa_length": 1053,
"cds_start": 2504,
"cds_end": null,
"cds_length": 3162,
"cdna_start": 2756,
"cdna_end": null,
"cdna_length": 4591,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286173.2"
},
{
"aa_ref": "D",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "C2CD5",
"gene_hgnc_id": 29062,
"hgvs_c": "c.2504A>T",
"hgvs_p": "p.Asp835Val",
"transcript": "ENST00000960572.1",
"protein_id": "ENSP00000630631.1",
"transcript_support_level": null,
"aa_start": 835,
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}
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}