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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 12-25966336-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=12&pos=25966336&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "12",
"pos": 25966336,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001164748.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-203+7188T>C",
"hgvs_p": null,
"transcript": "NM_001394098.1",
"protein_id": "NP_001381027.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000689635.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394098.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-203+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000689635.1",
"protein_id": "ENSP00000510086.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001394098.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000689635.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-109+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000405154.6",
"protein_id": "ENSP00000384491.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405154.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-203+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000381352.7",
"protein_id": "ENSP00000370756.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 392,
"cds_start": null,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381352.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-109+7188T>C",
"hgvs_p": null,
"transcript": "NM_001164748.2",
"protein_id": "NP_001158220.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164748.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-203+7994T>C",
"hgvs_p": null,
"transcript": "NM_001394094.1",
"protein_id": "NP_001381023.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394094.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-66+7994T>C",
"hgvs_p": null,
"transcript": "NM_001394095.1",
"protein_id": "NP_001381024.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394095.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-160+7994T>C",
"hgvs_p": null,
"transcript": "NM_001394096.1",
"protein_id": "NP_001381025.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394096.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-160+7188T>C",
"hgvs_p": null,
"transcript": "NM_001394097.1",
"protein_id": "NP_001381026.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394097.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-66+7188T>C",
"hgvs_p": null,
"transcript": "NM_001394099.1",
"protein_id": "NP_001381028.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394099.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-203+7994T>C",
"hgvs_p": null,
"transcript": "ENST00000688511.1",
"protein_id": "ENSP00000509001.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000688511.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-109+7994T>C",
"hgvs_p": null,
"transcript": "ENST00000689434.1",
"protein_id": "ENSP00000509645.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 419,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000689434.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-66+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000916362.1",
"protein_id": "ENSP00000586421.1",
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"aa_start": null,
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"aa_length": 419,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916362.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-186+7188T>C",
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"transcript": "ENST00000916363.1",
"protein_id": "ENSP00000586422.1",
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"biotype": "protein_coding",
"feature": "ENST00000916363.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-160+7994T>C",
"hgvs_p": null,
"transcript": "ENST00000953804.1",
"protein_id": "ENSP00000623863.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953804.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-331+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000953805.1",
"protein_id": "ENSP00000623864.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000953805.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-143+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000953806.1",
"protein_id": "ENSP00000623865.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953806.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-260+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000953807.1",
"protein_id": "ENSP00000623866.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953807.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-497+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000953808.1",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
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"hgvs_c": "c.-160+6951T>C",
"hgvs_p": null,
"transcript": "ENST00000953809.1",
"protein_id": "ENSP00000623868.1",
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"biotype": "protein_coding",
"feature": "ENST00000953809.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-237+7188T>C",
"hgvs_p": null,
"transcript": "ENST00000953810.1",
"protein_id": "ENSP00000623869.1",
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"aa_start": null,
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"aa_length": 419,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953810.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RASSF8",
"gene_hgnc_id": 13232,
"hgvs_c": "c.-203+7188T>C",
"hgvs_p": null,
"transcript": "NM_007211.5",
"protein_id": "NP_009142.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 392,
"cds_start": null,
"cds_end": null,
"cds_length": 1179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007211.5"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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}
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}